Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Colchicine | stimulates transport of rhodamine 123 | Cricetulus griseus | |
daunorubicin | stimulates transport of Hoechst 33342 | Cricetulus griseus | |
doxorubicin | stimulates transport of Hoechst 33342 | Cricetulus griseus | |
Hoechst 33342 | stimulates transport of rhodamine 123 | Cricetulus griseus | |
quercetin | stimulates transport of rhodamine 123 | Cricetulus griseus | |
rhodamine 123 | stimulates transport of Hoechst 33342 | Cricetulus griseus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actinomycin D | inhibits transport of Hoechst 3343 and rhodamine 123 | Cricetulus griseus | |
Colchicine | inhibits transport of Hoechst 3342 | Cricetulus griseus | |
daunorubicin | inhibits transport of rhodamine 123 | Cricetulus griseus | |
doxorubicin | inhibits transport of rhodamine 123 | Cricetulus griseus | |
etoposide | inhibits transport of Hoechst 3343 and rhodamine 123 | Cricetulus griseus | |
quercetin | inhibits transport of Hoechst 33342 | Cricetulus griseus | |
vinblastine | inhibits transport of Hoechst 3343 and rhodamine 123 | Cricetulus griseus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0135 | - |
rhodamine 123/in | - |
Cricetulus griseus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Cricetulus griseus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Cricetulus griseus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHRB30 cell | - |
Cricetulus griseus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hoechst 33342/in + ATP + H2O | i.e. 2-[2-(4-ethoxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazinyl)benzimidazole | Cricetulus griseus | Hoechst 33342/out + ADP + H2O | - |
? | |
additional information | the P-glycoprotein contains two distinct sites for drug binding and transport, these sites interact in a positively cooperative manner | Cricetulus griseus | ? | - |
? | |
rhodamine 123/in + ATP + H2O | - |
Cricetulus griseus | rhodamine 123/out + ADP + phosphate | - |
? |