Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(4-maleimidoanilino)-naphthalene-6-sulfonic acid | - |
Homo sapiens | |
cyclosporin A | - |
Homo sapiens | |
flavonoids | useful inhibitors for clinical application to multidrug resistance | Homo sapiens | |
quercetin | - |
Homo sapiens | |
verapamil | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | - |
? | - |
? | |
additional information | Rattus norvegicus | - |
? | - |
? | |
additional information | Homo sapiens | exports a diverse group of natural products chemotherapeutic drugs, and hydrophobic peptides across the plasma membrane | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | glycosylation is not essential for ATPase or transport function, the N-linked oligosaccharides appear to influence the conformation of the protein in a subtle way | Mus musculus |
glycoprotein | glycosylation is not essential for ATPase or transport function, the N-linked oligosaccharides appear to influence the conformation of the protein in a subtle way | Homo sapiens |
glycoprotein | glycosylation is not essential for ATPase or transport function, the N-linked oligosaccharides appear to influence the conformation of the protein in a subtle way | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RPMI-8226 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | - |
Mus musculus | ? | - |
? | |
additional information | - |
Rattus norvegicus | ? | - |
? | |
additional information | the enzyme operates in an alternating sites mechanism, that is when one catalytic site enters the transition state, the other is unable to do so | Homo sapiens | ? | - |
? | |
additional information | exports a diverse group of natural products chemotherapeutic drugs, and hydrophobic peptides across the plasma membrane | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme contains a membrane-associated domain made up of 12 alpha-helical membrane-spanning segments and two highly conserved cytosolic nucleotide-binding domains which couple ATP hydrolysis to substrate import or export | Homo sapiens |