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Literature summary for 7.6.2.2 extracted from

  • Hopper-Borge, E.; Xu, X.; Shen, T.; Shi, Z.; Chen, Z.S.; Kruh, G.D.
    Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B (2009), Cancer Res., 69, 178-184.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.2

Cloned(Commentary)

Cloned (Comment) Organism
MRP7 expression in HEK-293 cells, ectopic expression of MRP7 in mouse embryonic fibroblast deficient in P-glycoprotein and MRP1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by buthionine sulfoximine Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + xenobiotic/in Homo sapiens the enzyme increases the resistance level of cells against drugs, overview ADP + phosphate + xenobiotic/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 2',3'-dideoxycytidine/in
-
 Homo sapiens ADP + phosphate + 2',3'-dideoxycytidine/out
-
 ?
ATP + H2O + cytarabine/in
-
 Homo sapiens ADP + phosphate + cytarabine/out
-
 ?
ATP + H2O + daunorubicin/in
-
 Homo sapiens ADP + phosphate + daunorubicin/out
-
 ?
ATP + H2O + docetaxel/in
-
 Homo sapiens ADP + phosphate + docetaxel/out
-
 ?
ATP + H2O + epothilone B/in
-
 Homo sapiens ADP + phosphate + epothilone B/out
-
 ?
ATP + H2O + etoposide/in
-
 Homo sapiens ADP + phosphate + etoposide/out
-
 ?
ATP + H2O + gemcitabine/in
-
 Homo sapiens ADP + phosphate + gemcitabine/out
-
 ?
ATP + H2O + p-methoxy-ethylamphetamine/in
-
 Homo sapiens ADP + phosphate + p-methoxy-ethylamphetamine/out
-
 ?
ATP + H2O + paclitaxel/in
-
 Homo sapiens ADP + phosphate + paclitaxel/out
-
 ?
ATP + H2O + SN-38/in
-
 Homo sapiens ADP + phosphate + SN-38/out
-
 ?
ATP + H2O + vincristine/in
-
 Homo sapiens ADP + phosphate + vincristine/out
-
 ?
ATP + H2O + xenobiotic/in
-
 Homo sapiens ADP + phosphate + xenobiotic/out
-
 ?
ATP + H2O + xenobiotic/in the enzyme increases the resistance level of cells against drugs, overview Homo sapiens ADP + phosphate + xenobiotic/out
-
 ?
additional information MRP7 has a broad resistance profile for natural products, no transport activity with nontaxane antimicrotubule agents Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ABCC10
-
 Homo sapiens
MRP7
-
 Homo sapiens
multidrug resistance protein 7
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens