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Literature summary for 7.6.2.2 extracted from

  • Reuter, G.; Janvilisri, T.; Venter, H.; Shahi, S.; Balakrishnan, L.; van Veen, H.W.
    The ATP binding cassette multidrug transporter LmrA and lipid transporter MsbA have overlapping substrate specificities (2003), J. Biol. Chem., 278, 35193-35198.
    View publication on PubMed
Search for more literature for 7.6.2.2

Activating Compound

Activating Compound Comment Organism Structure
lipid A stimulates ATPase activity Lactococcus lactis

Cloned(Commentary)

Cloned (Comment) Organism
lmrA gene, expression in Escherichia coli WD2 Lactococcus lactis

Inhibitors

Inhibitors Comment Organism Structure
vanadate vanadate-sensitive ATPase activity Lactococcus lactis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Lactococcus lactis possible role for LmrA in lipid trafficking ?
-
 ?
additional information Lactococcus lactis NZ9000 possible role for LmrA in lipid trafficking ?
-
 ?

Organism

Organism UniProt Comment Textmining
Lactococcus lactis
-
-
-
Lactococcus lactis NZ9000
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/in Hoechst 33342 Lactococcus lactis ADP + phosphate + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/out
-
 ?
ATP + H2O + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/in Hoechst 33342 Lactococcus lactis NZ9000 ADP + phosphate + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/out
-
 ?
ATP + H2O + daunomycin/in
-
 Lactococcus lactis ADP + phosphate + daunomycin/out
-
 ?
ATP + H2O + daunomycin/in
-
 Lactococcus lactis NZ9000 ADP + phosphate + daunomycin/out
-
 ?
ATP + H2O + ethidium bromide/in recombinant LmrA, expressed in Escherichia coli WD2 Lactococcus lactis ADP + phosphate + ethidium bromide/out
-
 ?
ATP + H2O + Lipid A/in native LmrA Lactococcus lactis ADP + phosphate + Lipid A/out
-
 ?
ATP + H2O + vinblastine/in
-
 Lactococcus lactis ADP + phosphate + vinblastine/out
-
 ?
ATP + H2O + xenobiotic/in ABC multidrug transporter LmrA, substrate specificity Lactococcus lactis ADP + phosphate + xenobiotic/out
-
 ?
ATP + H2O + xenobiotic/in ABC multidrug transporter LmrA, substrate specificity Lactococcus lactis NZ9000 ADP + phosphate + xenobiotic/out
-
 ?
additional information possible role for LmrA in lipid trafficking Lactococcus lactis ?
-
 ?
additional information LmrA and the lipid transporter MsbA in Escherichia coli have overlapping specificities for Lipid A and chemotherapeutic and cytotoxic drugs Lactococcus lactis ?
-
 ?
additional information possible role for LmrA in lipid trafficking Lactococcus lactis NZ9000 ?
-
 ?
additional information LmrA and the lipid transporter MsbA in Escherichia coli have overlapping specificities for Lipid A and chemotherapeutic and cytotoxic drugs Lactococcus lactis NZ9000 ?
-
 ?

Synonyms

Synonyms Comment Organism
LmrA
-
 Lactococcus lactis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at, ATPase activity Lactococcus lactis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at, ATPase activity Lactococcus lactis