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Literature summary for 7.6.2.2 extracted from

  • Orelle, C.; Dalmas, O.; Gros, P.; Di Pietro, A.; Jault, J.M.
    The conserved glutamate residue adjacent to the Walker-B motif is the catalytic base for ATP hydrolysis in the ATP-binding cassette transporter BmrA (2003), J. Biol. Chem., 278, 47002-47008.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E504A mutant is fully devoid of ATPase activity Bacillus subtilis
E504C mutant is fully devoid of ATPase activity Bacillus subtilis
E504D mutant is fully devoid of ATPase activity Bacillus subtilis
E504Q mutant is fully devoid of ATPase activity Bacillus subtilis
E504S mutant is fully devoid of ATPase activity Bacillus subtilis

Inhibitors

Inhibitors Comment Organism Structure
vanadate
-
Bacillus subtilis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Bacillus subtilis 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Mg2+-dependence of 8-aza-ATP binding to wild-type and mutant BmrA Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bacillus subtilis BmrA is a half-ABC transporter involved in multidrug resistance ?
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
wild-type and mutant BmrA Bacillus subtilis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2
-
pH 8, 37°C, 8-aza-ATPase activity Bacillus subtilis
6.5
-
pH 8, 37°C, ATPase activity Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-aza-ATP + H2O + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/in 8-aza-ATP is a fairly good substrate of BmrA Bacillus subtilis 8-aza-ADP + phosphate + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/out
-
?
ATP + H2O + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/in Hoechst 33342, half-ABC transporter BmrA, Glu-504, adjacent to the Walker-B motif, is the catalytic base for ATP hydrolysis Bacillus subtilis ADP + phosphate + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/out
-
?
additional information BmrA is a half-ABC transporter involved in multidrug resistance Bacillus subtilis ?
-
?

Synonyms

Synonyms Comment Organism
BmrA formerly known as YvcC Bacillus subtilis
YvcC renamed BmrA Bacillus subtilis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bacillus subtilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Bacillus subtilis