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Literature summary for 7.6.2.2 extracted from

  • Campos, M.C.; Castro-Pinto, D.B.; Ribeiro, G.A.; Berredo-Pinho, M.M.; Gomes, L.H.; da Silva Bellieny, M.S.; Goulart, C.M.; Echevarria, A.; Leon, L.L.
    P-glycoprotein efflux pump plays an important role in Trypanosoma cruzi drug resistance (2013), Parasitol. Res., 112, 2341-2351.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
cyclosporin A
-
 Trypanosoma cruzi
orthovanadate
-
 Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Trypanosoma cruzi 16020
-

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-
Trypanosoma cruzi Y
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
 Trypanosoma cruzi
-
epimastigote
-
 Trypanosoma cruzi
-
trypomastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 4-N-(2'-methoxystyryl)-thiosemicarbazone/in
-
 Trypanosoma cruzi ADP + phosphate + 4-N-(2'-methoxystyryl)-thiosemicarbazone/out
-
 ?
ATP + H2O + 4-N-(2'-methoxystyryl)-thiosemicarbazone/in
-
 Trypanosoma cruzi Y ADP + phosphate + 4-N-(2'-methoxystyryl)-thiosemicarbazone/out
-
 ?
ATP + H2O + N-benzyl-2-nitro-1H-imidazole-1-acetamide/in
-
 Trypanosoma cruzi ADP + phosphate + N-benzyl-2-nitro-1H-imidazole-1-acetamide/out
-
 ?
ATP + H2O + N-benzyl-2-nitro-1H-imidazole-1-acetamide/in
-
 Trypanosoma cruzi Y ADP + phosphate + N-benzyl-2-nitro-1H-imidazole-1-acetamide/out
-
 ?
ATP + H2O + rhodamine 123/in
-
 Trypanosoma cruzi ADP + phosphate + rhodamine 123/out
-
 ?
ATP + H2O + rhodamine 123/in
-
 Trypanosoma cruzi Y ADP + phosphate + rhodamine 123/out
-
 ?
ATP + H2O + verapamil/in
-
 Trypanosoma cruzi ADP + phosphate + verapamil/out
-
 ?
ATP + H2O + verapamil/in
-
 Trypanosoma cruzi Y ADP + phosphate + verapamil/out
-
 ?

Synonyms

Synonyms Comment Organism
P-glycoprotein
-
 Trypanosoma cruzi
Pgp
-
 Trypanosoma cruzi
PGP1 isoform Trypanosoma cruzi
Pgp2 isoform Trypanosoma cruzi

General Information

General Information Comment Organism
physiological function the enzyme participates in drug resistance Trypanosoma cruzi