Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-4-[(1a,6,10b)-1,1-dichloro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-[(5-quinolinyloxy)methyl]-1-piperazineethanol | complete inhibition of P-glycoprotein at 0.005 mM | Homo sapiens | |
(R)-4-[(1a,6,10b)-1,1-difluoro-1,1a,6,10btetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-[(5-quin-olinyloxy)methyl]-1-piperazineethanol | LSN 335979, P-glycoprotein-specific inhibitor | Homo sapiens | |
2,6-bis(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thien-2-yl)thiopyrylium chloride | 81% inhibition of MRP1 at 0.01 mM | Homo sapiens | |
2,6-bis(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonyl)thien-2-yl)thiopyrylium hexafluorophosphate | 78% inhibition of MRP1 at 0.01 mM | Homo sapiens | |
2,6-di-tert-butyl-4-(5-(piperidine-1-carbonothioyl)thien-2-yl)thiopyrylium hexafluorophosphate | 11% inhibition of MRP1 at 0.01 mM | Homo sapiens | |
2,6-di-tert-butyl-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride | 32% inhibition of MRP1 at 0.01 mM | Homo sapiens | |
2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonothioyl)thiophen-2-yl)thiopyrylium chloride | 93% inhibition of MRP1 at 0.01 mM | Homo sapiens | |
2-tert-butyl-6-(4-(dimethylamino)phenyl)-4-(5-(piperidine-1-carbonyl)thien-2-yl)thiopyrylium hexafluorophosphate | 59% inhibition of MRP1 at 0.01 mM | Homo sapiens | |
verapamil | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
190000 | - |
x * 190000, MRP1, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + xenobiotic/in | Homo sapiens | - |
ADP + phosphate + xenobiotic/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + calcein/in | - |
Homo sapiens | ADP + phosphate + calcein/out | - |
? | |
ATP + H2O + estradiol glucuronide/in | - |
Homo sapiens | ADP + phosphate + estradiol glucuronide/out | - |
? | |
ATP + H2O + vinblastine/in | - |
Homo sapiens | ADP + phosphate + vinblastine/out | - |
? | |
ATP + H2O + xenobiotic/in | - |
Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 190000, MRP1, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ABCB1 | - |
Homo sapiens |
ABCC1 | - |
Homo sapiens |
MRP1 | - |
Homo sapiens |
multidrug resistance protein 1 | - |
Homo sapiens |
P-glycoprotein | - |
Homo sapiens |
P-gp | - |
Homo sapiens |