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Literature summary for 7.6.2.2 extracted from

  • Paul, S.; Breuninger, L.M.; Tew, K.D.; Shen, H.; Kruh, G.D.
    ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles estabilshes MRP as a broad specificity transporter (1996), Proc. Natl. Acad. Sci. USA, 93, 6929-6934.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
arsenate competitive Mus musculus
GSH competitive Mus musculus
GSSG competitive Mus musculus
leukotriene D4 competitive Mus musculus
MK571 competitive Mus musculus
S-(2,4-dinitrophenyl)glutathione competitive Mus musculus
S-(p-azidophenylacyl)-glutathione competitive Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000035
-
 leukotriene C4/in
-
 Mus musculus
0.0042
-
 vincristine/in
-
 Mus musculus
0.0044
-
 etoposide/in
-
 Mus musculus
0.0063
-
 daunorubicin/in
-
 Mus musculus
0.038
-
 ATP
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell NIH 3T3 MRP transfectant pSRalpha-MRP-32 cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
daunorubicin/in + ATP + H2O
-
 Mus musculus daunorubicin/out + ADP + phosphate
-
 ?
etoposide/in + ATP + H2O
-
 Mus musculus etoposide/out + ADP + phosphate
-
 ?
leukotriene C4/in + ATP + H2O
-
 Mus musculus leukotriene C4/out + ADP + phosphate
-
 ?
taxol/in + ATP + H2O weak activity Mus musculus taxol/out + ADP + H2O
-
 ?
vinblastine/in + ATP + H2O weak activity Mus musculus vinblastine/out + ADP + phosphate
-
 ?
vincristine/in + ATP + H2O
-
 Mus musculus vincristine/out + ADP + phosphate
-
 ?