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Literature summary for 7.6.2.2 extracted from
- The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes (1997), Adv. Enzyme Regul., 37, 321-333.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00025 | - |
leukotriene C4/in | - |
Rattus norvegicus |  |
| 0.111 | - |
GSSG/in | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | - |
Rattus norvegicus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | - |
? | - |
? | |
| additional information | Homo sapiens | the deficient expression of cMRP appears as the basis of the transport defect in human Dubin-Johnson syndrome | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | - |
Homo sapiens | - |
| hepatocyte | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3alpha-sulfatolithocholyltaurine/in + ATP + H2O | - |
Rattus norvegicus | 3alpha-sulfatolithocholyltaurine/out + ADP + phosphate | - |
? | |
| ATP + H2O + GSSG/in | - |
Rattus norvegicus | ADP + phosphate + GSSG/out | - |
? | |
| estradiol 17-beta-D-glucuronide/in + ATP + H2O | - |
Homo sapiens | estradiol 17-beta-D-glucuronide/out + ADP + phosphate | - |
? | |
| estradiol 17-beta-D-glucuronide/in + ATP + H2O | - |
Rattus norvegicus | estradiol 17-beta-D-glucuronide/out + ADP + phosphate | - |
? | |
| GSH/in + ATP + H2O | - |
Rattus norvegicus | GSH/out + ADP + phosphate | - |
? | |
| leukotriene C4/in + ATP + H2O | - |
Homo sapiens | leukotriene C4/out + ADP + phosphate | - |
? | |
| leukotriene C4/in + ATP + H2O | - |
Rattus norvegicus | leukotriene C4/out + ADP + phosphate | - |
? | |
| leukotriene D4/in + ATP + H2O | - |
Homo sapiens | leukotriene D4/out + ADP + phosphate | - |
? | |
| leukotriene D4/in + ATP + H2O | - |
Rattus norvegicus | leukotriene D4/out + ADP + phosphate | - |
? | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| additional information | the deficient expression of cMRP appears as the basis of the transport defect in human Dubin-Johnson syndrome | Homo sapiens | ? | - |
? | |
| S-(2,4-dinitrophenyl)glutathione/in + ATP + H2O | - |
Homo sapiens | S-(2,4-dinitrophenyl)glutathione/out + ADP + phosphate | - |
? | |
| S-(2,4-dinitrophenyl)glutathione/in + ATP + H2O | - |
Rattus norvegicus | S-(2,4-dinitrophenyl)glutathione/out + ADP + phosphate | - |
? | |
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Release 2023.1 (January 2023)
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