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Literature summary for 7.6.2.2 extracted from
- Cyclooxygenase-2 inhibitors prevent trinitrobenzene sulfonic acid-induced P-glycoprotein up-regulation in vitro and in vivo (2010), Eur. J. Pharmacol., 636, 189-197.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Caco-2 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCB1 | - |
Homo sapiens |
| MDR1 | - |
Homo sapiens |
| P-glycoprotein | - |
Homo sapiens |
| P-gp | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | P-gp down-regulation by cyclooxygenase-2 inhibitors (indomethacin heptyl ester and nimesulide) can confer the diminution of drugs resistance, and consequently ameliorate the response to medical therapy in inflammatory bowel disease | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme can actively pump drugs out of cells conferring the phenotype of multidrug resistance | Homo sapiens |
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Release 2023.1 (January 2023)
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