Literature summary for 7.6.2.2 extracted from

Wijnholds, J.; Mol, C.A.A.M.; van Deemter, L.; de Haas, M.; Scheffer, G.L.; Baas, F.; Beijnen, J.H.; Scheper, R.J.; Hatse, S.; de Clercq, E.; Balzarini, J.; Borst, P.
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs (2000), Proc. Natl. Acad. Sci. USA, 97, 7476-7481.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
sulfinpyrazone	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	the enzyme is a transmembrane protein	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	MRP5 might play a role in some cases of unexplained resistance to thiopurines in acute lymphoblastic leukemia and/or antiretroviral nucleoside analogs in HIV-infected patients	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	MRP5	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	293 human embryonic kidney cells and Madin-darby canine kidney II cells transfected with a MRP5 cDNA construct	Homo sapiens	-
HL-60 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-mercaptopurine/in + ATP + H2O	-	Homo sapiens	6-mercaptopurine/out + ADP + phosphate	-	?
9-(2-phosphonylmethoxyethyl)adenine/in + ATP + H2O	-	Homo sapiens	9-(2-phosphonylmethoxyethyl)adenine/out + ADP + phosphate	-	?
additional information	MRP5 might play a role in some cases of unexplained resistance to thiopurines in acute lymphoblastic leukemia and/or antiretroviral nucleoside analogs in HIV-infected patients	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)