Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane | stimulates ATPase activity by 2.7-fold | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane | competitive inhibitor to doxorubicin binding by P-glycoprotein | Homo sapiens | |
apigenin | - |
Homo sapiens | |
cyclosporine A | - |
Homo sapiens | |
Ko143 | - |
Homo sapiens | |
valspodar | - |
Homo sapiens | |
verapamil | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MDA435/LCC6MDR1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + 1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane/in | - |
Homo sapiens | ADP + phosphate + 1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane/out | - |
? | |
ATP + H2O + doxorubicin/in | - |
Homo sapiens | ADP + phosphate + doxorubicin/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
P-glycoprotein | - |
Homo sapiens |
P-gp | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00028 | 0.00034 | 1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane | at 37°C, pH not specified in the publication | Homo sapiens |