Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arsenate | competitive inhibitor of daunorubicin transport | Homo sapiens | |
azidophenacylglutathione | competitive inhibitor of daunorubicin transport | Homo sapiens | |
cyclosporin A | weak competitive inhibitor of daunorubicin transport | Homo sapiens | |
genistein | competitive inhibitor of daunorubicin transport | Homo sapiens | |
GSH | competitive inhibitor of daunorubicin transport | Homo sapiens | |
GSSG | competitive inhibitor of daunorubicin transport | Homo sapiens | |
MK571 | competitive inhibitor of daunorubicin transport | Homo sapiens | |
PSC833 | weak competitive inhibitor of daunorubicin transport | Homo sapiens | |
verapamil | weak competitive inhibitor of daunorubicin transport | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0055 | - |
vincristine/in | - |
Homo sapiens | |
0.0057 | - |
etoposide/in | - |
Homo sapiens | |
0.0061 | - |
daunorubicin/in | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme confers cellular resistance to a variety of natural product cytotoxic agents | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HL-60 cell | MRP-overexpressing HL60/ADR cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
daunorubicin/in + ATP + H2O | - |
Homo sapiens | daunorubicin/out + ADP + phosphate | - |
? | |
etoposide/in + ATP + H2O | - |
Homo sapiens | etoposide/out + ADP + phosphate | - |
? | |
additional information | enzyme confers cellular resistance to a variety of natural product cytotoxic agents | Homo sapiens | ? | - |
? | |
vincristine/in + ATP + H2O | - |
Homo sapiens | vincristine/out + ADP + phosphate | - |
? |