Cloned (Comment) | Organism |
---|---|
expression in Pichia pastoris | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,6-bis(dimethylamino)-9-(4-dimethylaminophenyl)-thioxanthylium hexafluorophosphate | competitive inhibition of verapamil-dependent ATPase-activity | Mus musculus | |
3,6-bis(dimethylamino)-9-phenyl-selenoxanthylium bromide | i.e. selenium-derivative of tetramethylrosamine, competitive inhibition of verapamil-dependent ATPase-activity | Mus musculus | |
N-methyl-N-(9-phenyl-2,3,6,7-tetrahydro-1H,5H,12H-pyrido[3,2,1-ij]selenochromeno[2,3-f]quinolin-12-ylidene)methanaminium hexafluorophosphate | competitive inhibition of verapamil-dependent ATPase-activity | Mus musculus | |
N-methyl-N-(9-phenyl-2,3,6,7-tetrahydro-1H,5H,12H-pyrido[3,2,1-ij]thiochromeno[2,3-f]quinolin-12-ylidene)methanaminium hexafluorophosphate | competitive inhibition of verapamil-dependent ATPase-activity | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.074 | - |
3,6-bis(dimethylamino)-9-phenyl-selenoxanthylium bromide | pH 7.4, 37°C | Mus musculus | |
0.078 | - |
N-methyl-N-(9-phenyl-2,3,6,7-tetrahydro-1H,5H,12H-pyrido[3,2,1-ij]thiochromeno[2,3-f]quinolin-12-ylidene)methanaminium hexafluorophosphate | pH 7.4, 37°C | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isoform Mdr3 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,6-bis(dimethylamino)-9-phenyl-selenoxanthylium bromide/in + ATP + H2O | - |
Mus musculus | 3,6-bis(dimethylamino)-9-phenyl-selenoxanthylium bromide/out + ADP + phosphate | - |
? | |
N-methyl-N-(9-phenyl-2,3,6,7-tetrahydro-1H,5H,12H-pyrido[3,2,1-ij]selenochromeno[2,3-f]quinolin-12-ylidene)methanaminium hexafluorophosphate/in + ATP + H2O | - |
Mus musculus | N-methyl-N-(9-phenyl-2,3,6,7-tetrahydro-1H,5H,12H-pyrido[3,2,1-ij]thiochromeno[2,3-f]quinolin-12-ylidene)methanaminium hexafluorophosphate/out + ADP + phosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
N-methyl-N-(9-phenyl-2,3,6,7-tetrahydro-1H,5H,12H-pyrido[3,2,1-ij]thiochromeno[2,3-f]quinolin-12-ylidene)methanaminium hexafluorophosphate | pH 7.4, 37°C | Mus musculus | |
0.007 | - |
N-methyl-N-(9-phenyl-2,3,6,7-tetrahydro-1H,5H,12H-pyrido[3,2,1-ij]selenochromeno[2,3-f]quinolin-12-ylidene)methanaminium hexafluorophosphate | pH 7.4, 37°C | Mus musculus | |
0.008 | - |
3,6-bis(dimethylamino)-9-(4-dimethylaminophenyl)-thioxanthylium hexafluorophosphate | pH 7.4, 37°C | Mus musculus |