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Literature summary for 7.6.2.2 extracted from

  • Prasad, R.; Banerjee, A.; Khandelwal, N.K.; Dhamgaye, S.
    The ABCs of Candida albicans multidrug transporter Cdr1 (2015), Eukaryot. Cell, 14, 1154-1164.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
curcumin
-
Candida albicans
RC21v3 potent inhibitor Candida albicans

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Candida albicans 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
16990
-
x * 16990, calculated from amino acid sequence Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + beta-estradiol/in Candida albicans
-
ADP + phosphate + beta-estradiol/out
-
?
ATP + H2O + corticosterone/in Candida albicans
-
ADP + phosphate + corticosterone/out
-
?
ATP + H2O + fluconazole/in Candida albicans
-
ADP + phosphate + fluconazole/out
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + beta-estradiol/in
-
Candida albicans ADP + phosphate + beta-estradiol/out
-
?
ATP + H2O + corticosterone/in
-
Candida albicans ADP + phosphate + corticosterone/out
-
?
ATP + H2O + fluconazole/in
-
Candida albicans ADP + phosphate + fluconazole/out
-
?

Subunits

Subunits Comment Organism
? x * 16990, calculated from amino acid sequence Candida albicans

Synonyms

Synonyms Comment Organism
Candida drug resistance 1 protein
-
Candida albicans
Cdr1p
-
Candida albicans
multidrug transporter
-
Candida albicans

General Information

General Information Comment Organism
physiological function the enzyme is a major player in multidrug resistance Candida albicans