Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.6.2.2 extracted from

  • Johnson, Z.L.; Chen, J.
    Structural basis of substrate recognition by the multidrug resistance protein MRP1 (2017), Cell, 168, 1075-1085 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
ATP pH and temperature not specified in the publication Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + xenobiotic[side 1] Bos taurus
-
ADP + phosphate + xenobiotic[side 2]
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus Q8HXQ5
-
-

Purification (Commentary)

Purification (Comment) Organism
Sepharose 4 column chromatography and Superose 6 gel filtration Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + actinomycin D[side 1]
-
Bos taurus ADP + phosphate + actinomycin D[side 2]
-
?
ATP + H2O + digitonin[side 1]
-
Bos taurus ADP + phosphate + digitonin[side 2]
-
?
ATP + H2O + vinblastine[side 1]
-
Bos taurus ADP + phosphate + vinblastine[side 2]
-
?
ATP + H2O + vincristine[side 1]
-
Bos taurus ADP + phosphate + vincristine[side 2]
-
?
ATP + H2O + xenobiotic[side 1]
-
Bos taurus ADP + phosphate + xenobiotic[side 2]
-
?

Subunits

Subunits Comment Organism
? x * 148000, calculated from amino acid sequence Bos taurus

Synonyms

Synonyms Comment Organism
ABCC1
-
Bos taurus
MRP1
-
Bos taurus
multidrug resistance protein 1
-
Bos taurus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.078
-
ATP pH and temperature not specified in the publication Bos taurus