Literature summary for 7.6.2.2 extracted from

Booth-Genthe, C.L.; Louie, S.W.; Carlini, E.J.; Li, B.; Leake, B.F.; Eisenhandler, R.; Hochman, J.H.; Mei, Q.; Kim, R.B.; Rushmore, T.H.; Yamazaki, M.
Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse (2006), J. Pharmacol. Toxicol. Methods, 54, 78-89.

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Cloned(Commentary)

Cloned (Comment)	Organism
two forms of abcb1a are cloned from Sprague-Dawley cDNA that differ by six amino acids and a base pair deletion. The intact form is stably transfected in LLC-PK1 cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
cyclosporin A	inhibits transport of dexamethasone, ritonavir and vinblastine	Rattus norvegicus
quinidine	inhibits transport of dexamethasone, ritonavir and vinblastine	Rattus norvegicus
verapamil	inhibits transport of dexamethasone, ritonavir and vinblastine	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + dexamethasone/in	-	Rattus norvegicus	ADP + phosphate + dexamethasone/out	-	?
ATP + H2O + ritonavir/in	-	Rattus norvegicus	ADP + phosphate + ritonavir/out	-	?
ATP + H2O + vinblastine/in	-	Rattus norvegicus	ADP + phosphate + vinblastine/out	-	?

Synonyms

Synonyms	Comment	Organism
Abcb1a	-	Rattus norvegicus
Mdr1a	-	Rattus norvegicus

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Release 2023.1 (January 2023)