EC Number   |
Application |
Reference |
|---|
   7.6.2.2 | analysis |
evaluation of high-speed ATPase activity assay method by comparing with in vitro transport assay systems using MDR1-transfected MDR1-MDCK cells. The kinetic parameters obtained in ATPase activity assay are not necessarily corresponding with those in in vitro transport assay. The combination of the ATPase activity assay and in vitro transport technologies gives insight into mechanisms |
685450 |
| 7.6.2.2 | analysis |
use of in vitro transporter assays for analysis of the role of P-glycoprotein mediated efflux activity. The transwell assay is a valuable tool to evaluate human P-glycoprotein interaction with compounds for assessing brain penetration of new chemical entities |
686359 |
| 7.6.2.2 | analysis |
use of in vitro transporter assays for analysis of the role of P-glycoprotein mediated efflux activity. The transwell assay is a valuable tool to evaluate P-glycoprotein interaction with compounds for assessing brain penetration of new chemical entities |
686359 |
| 7.6.2.2 | analysis |
use of pharmacophore models for the prediction of binding to P-glycoprotein |
686349 |
| 7.6.2.2 | biofuel production |
gene overexpression in industrial yeast strains improves the alcoholic fermentation performance for sustainable bio-ethanol production |
-, 734628 |
| 7.6.2.2 | diagnostics |
in patients with neuroblastoma, increased MRP4 expression has prognostic value |
701356 |
| 7.6.2.2 | drug development |
MRP4 is a potential target for drug development, e.g. in the treatment of hyperuricaemia |
701356 |
| 7.6.2.2 | medicine |
ATP-driven pumping of a variety of drugs out of cells by P-glycoprotein poses a serious problem to medical therapy |
659188 |
| 7.6.2.2 | medicine |
development of a method for predicting the risk of drug-drug interactions involving inhibition of P-glycoprotein |
713592 |
| 7.6.2.2 | medicine |
lovastatin increases the absorption of verapamil (used as an antiarrhythmic agent to control supraventricular tachyarrhythmias) by inhibiting P-glycoprotein |
711894 |
