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Literature summary for 7.6.2.2 extracted from
- Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas (2008), Eur. J. Clin. Invest., 38, 134-142.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the intrinsic multidrug resistance, MDR, of cholangiocellular and gallbladder carcinomas seems to be independent of MRP2 expression while the expression of MRP3 may contribute to the MDR phenotype | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cholangiocellular carcinoma cell | MRP3 is the predominant MRP isoform in cholangiocellular carcinomas (57%), whereas MRP2 is undetectable in cholangiocellular carcinomas | Homo sapiens | - |
| gall bladder cancer cell | MRP3 is the predominant MRP isoform in gallbladder carcinomas (93%), whereas MRP2 expression is detected in only 29% of gallbladder carcinomas | Homo sapiens | - |
| Mz-ChA-1 cell | constitutive expression of MDR P-glycoproteins, MRP1, MRP2 and MRP3 in Mz-ChA-1 cells. MRP2 and MRP3 are expressed in the respective apical and basolateral membrane domains, isozyme expression analysis amd immunohistochemic localization analysis, overview | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the intrinsic multidrug resistance, MDR, of cholangiocellular and gallbladder carcinomas seems to be independent of MRP2 expression while the expression of MRP3 may contribute to the MDR phenotype | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MDR | - |
Homo sapiens |
| MRP2 | - |
Homo sapiens |
| MRP3 | - |
Homo sapiens |
| multidrug resistance protein | - |
Homo sapiens |
| P-glycoprotein | - |
Homo sapiens |
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