EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
melanoma cell |
- |
760802 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
melanoma cell |
- |
761332 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
melanoma cell |
- |
711107 |
1.13.11.53 | acireductone dioxygenase (Ni2+-requiring) |
melanoma cell |
- |
764226 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
melanoma cell |
- |
713361 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
melanoma cell |
- |
685815 |
1.14.15.18 | calcidiol 1-monooxygenase |
melanoma cell |
- |
659811 |
1.14.16.4 | tryptophan 5-monooxygenase |
melanoma cell |
- |
658187 |
1.14.18.1 | tyrosinase |
melanoma cell |
- |
636339, 636340, 636355, 636360, 636374, 636398, 636401, 636402, 636412, 636416, 636417, 636418, 636422, 636425, 636430, 696686, 744671, 746188, 746346 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
melanoma cell |
- |
-, 725514, 742841 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
melanoma cell |
- |
742556 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
melanoma cell |
- |
746204 |
2.1.1.366 | [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase |
melanoma cell |
- |
759353 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
melanoma cell |
- |
705661 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
melanoma cell |
- |
487039 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
melanoma cell |
- |
759839 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
melanoma cell |
- |
688812, 735724, 759316 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
melanoma cell |
- |
735724 |
2.4.1.274 | glucosylceramide beta-1,4-galactosyltransferase |
melanoma cell |
- |
736198 |
2.4.1.80 | ceramide glucosyltransferase |
melanoma cell |
- |
735591 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
melanoma cell |
- |
735872, 760200 |
2.4.2.28 | S-methyl-5'-thioadenosine phosphorylase |
melanoma cell |
- |
671628 |
2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase |
melanoma cell |
- |
637260 |
2.4.3.8 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase |
melanoma cell |
- |
735601, 764085, 764812 |
2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase |
melanoma cell |
- |
736209, 764220 |
2.7.1.107 | diacylglycerol kinase (ATP) |
melanoma cell |
- |
672420 |
2.7.1.147 | ADP-specific glucose/glucosamine kinase |
melanoma cell |
- |
723169 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
melanoma cell |
- |
721967 |
2.7.1.91 | sphingosine kinase |
melanoma cell |
- |
671356, 761980 |
2.7.11.1 | non-specific serine/threonine protein kinase |
melanoma cell |
- |
662601 |
2.7.11.20 | elongation factor 2 kinase |
melanoma cell |
- |
760309 |
2.7.11.22 | cyclin-dependent kinase |
melanoma cell |
- |
665840 |
2.7.11.26 | tau-protein kinase |
melanoma cell |
- |
740135 |
2.7.12.2 | mitogen-activated protein kinase kinase |
melanoma cell |
- |
740419 |
2.7.7.49 | RNA-directed DNA polymerase |
melanoma cell |
- |
692248 |
2.7.7.8 | polyribonucleotide nucleotidyltransferase |
melanoma cell |
- |
672972, 723628 |
2.8.1.2 | 3-mercaptopyruvate sulfurtransferase |
melanoma cell |
- |
713731 |
3.1.3.16 | protein-serine/threonine phosphatase |
melanoma cell |
- |
708789 |
3.1.3.36 | phosphoinositide 5-phosphatase |
melanoma cell |
- |
730456 |
3.1.3.5 | 5'-nucleotidase |
melanoma cell |
- |
677542 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
melanoma cell |
- |
696397 |
3.2.1.24 | alpha-mannosidase |
melanoma cell |
- |
665978 |
3.2.2.29 | thymine-DNA glycosylase |
melanoma cell |
- |
706938, 751763 |
3.4.11.2 | membrane alanyl aminopeptidase |
melanoma cell |
- |
35865, 664466, 665112 |
3.4.14.5 | dipeptidyl-peptidase IV |
melanoma cell |
- |
703784 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
melanoma cell |
- |
752892 |
3.4.21.5 | thrombin |
melanoma cell |
- |
717955 |
3.4.21.53 | Endopeptidase La |
melanoma cell |
- |
731618 |
3.4.21.61 | Kexin |
melanoma cell |
- |
732728 |
3.4.21.68 | t-Plasminogen activator |
melanoma cell |
- |
29577, 29592 |
3.4.21.75 | Furin |
melanoma cell |
- |
753199 |
3.4.21.B27 | proprotein convertase 7 |
melanoma cell |
- |
753199 |
3.4.22.1 | cathepsin B |
melanoma cell |
- |
681195, 753138 |
3.4.22.15 | cathepsin L |
melanoma cell |
- |
696091, 712921 |
3.4.22.36 | caspase-1 |
melanoma cell |
- |
709153 |
3.4.22.43 | cathepsin V |
melanoma cell |
- |
752678 |
3.4.22.52 | calpain-1 |
melanoma cell |
- |
709406 |
3.4.22.54 | calpain-3 |
melanoma cell |
- |
708013 |
3.4.22.56 | caspase-3 |
melanoma cell |
- |
700600 |
3.4.24.16 | neurolysin |
melanoma cell |
- |
-, 754898 |
3.4.24.24 | gelatinase A |
melanoma cell |
- |
684054, 752865 |
3.4.24.56 | insulysin |
melanoma cell |
- |
668184 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
melanoma cell |
- |
734297 |
3.4.24.81 | ADAM10 endopeptidase |
melanoma cell |
- |
668181 |
3.4.24.B4 | matrix metalloproteinase-13 |
melanoma cell |
- |
650906, 720440 |
3.4.25.1 | proteasome endopeptidase complex |
melanoma cell |
- |
711671 |
3.5.1.23 | ceramidase |
melanoma cell |
- |
735256 |
3.6.4.13 | RNA helicase |
melanoma cell |
- |
757299 |
3.6.5.2 | small monomeric GTPase |
melanoma cell |
- |
756339 |
4.1.1.17 | ornithine decarboxylase |
melanoma cell |
- |
677508 |
4.1.1.50 | adenosylmethionine decarboxylase |
melanoma cell |
- |
4690 |
4.4.1.5 | lactoylglutathione lyase |
melanoma cell |
- |
709815 |
5.1.99.4 | alpha-methylacyl-CoA racemase |
melanoma cell |
- |
749413 |
5.3.1.9 | glucose-6-phosphate isomerase |
melanoma cell |
- |
704574 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
- |
648805, 648814, 748797 |
5.3.99.2 | Prostaglandin-D synthase |
melanoma cell |
- |
748450 |
5.6.2.1 | DNA topoisomerase |
melanoma cell |
- |
714760 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
melanoma cell |
- |
726691 |
7.3.2.7 | arsenite-transporting ATPase |
melanoma cell |
- |
697072 |
7.4.2.14 | ABC-type antigen peptide transporter |
melanoma cell |
- |
761911 |
7.4.2.5 | bacterial ABC-type protein transporter |
melanoma cell |
- |
700137 |
3.4.24.B9 | ADAM9 endopeptidase |
melanoma cell |
ADAM-9 is expressed in human melanoma at the tumor-stroma border where direct or indirect interactions between tumor cells and fibroblasts occur |
719997 |
2.3.3.10 | hydroxymethylglutaryl-CoA synthase |
melanoma cell |
although HMGCS1 expression does not correlate with BRAFV600E mutation in human melanoma cells, HMGCS1 is selectively important for proliferation of BRAFV600E-positive melanoma and colon cancer cells but not control cells harboring activeN/KRAS mutants, and stable knockdown of HMGCS1 only attenuated colony formation and tumor growth potential of BRAFV600E melanoma cells |
757174 |
1.8.1.9 | thioredoxin-disulfide reductase |
melanoma cell |
amelanotic |
394906 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
B16 |
648811, 648812 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
B16 melanoma |
648815 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
B16/F10 |
648807 |
4.1.1.33 | diphosphomevalonate decarboxylase |
melanoma cell |
B16F10 |
650501 |
2.4.1.90 | N-acetyllactosamine synthase |
melanoma cell |
Bowes melanoma cell line |
658123 |
3.4.22.15 | cathepsin L |
melanoma cell |
cathepsin L activity was detected in the cell culture supernatant by lithium dodecyl sulfate gelatin zymography |
667194 |
3.4.21.68 | t-Plasminogen activator |
melanoma cell |
cell-conditioned serum-free medium, Bowes |
29587 |
2.7.12.2 | mitogen-activated protein kinase kinase |
melanoma cell |
choroidal from eyes, and cutaneous |
665489 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
Cloudman mouse melanoma cells |
648804 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
Cloudman mouse melanoma cells (S91) |
648809 |
3.4.24.B4 | matrix metalloproteinase-13 |
melanoma cell |
cutaneous malignant melanoma |
668973 |
3.2.1.49 | alpha-N-acetylgalactosaminidase |
melanoma cell |
cutaneous melanoma, specific enzymatic activity of serum alpha-N-acetylgalactosaminidase is significantly increased in stage III melanoma patients, but not in early stages |
707963 |
1.5.1.3 | dihydrofolate reductase |
melanoma cell |
DHFR is overexpressed in melanoma cells |
705800 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
melanoma cell |
diverse cell lines |
715720 |
2.7.10.2 | non-specific protein-tyrosine kinase |
melanoma cell |
elevated levels of malignant cells |
490359 |
3.4.24.B7 | matrix metalloproteinase-26 |
melanoma cell |
elevated MMP-26 expression level |
710794 |