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BRENDA support

Information on EC 2.7.1.91 - sphingosine kinase

for references in articles please use BRENDA:EC2.7.1.91

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IUBMB Comments

The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
sphk1, sphingosine kinase, sphk2, sphingosine kinase 1, sphingosine kinase-1, sphingosine kinase 2, sphk-1, sphingosine kinase-2, sphk1a, sphingosine kinase type 1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
ceramide and sphingolipid recycling and degradation (yeast), ceramide degradation (generic), sphingolipid biosynthesis (plants), sphingosine and sphingosine-1-phosphate metabolism