Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | calcineurin is dependent on Ca2+/calmodulin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclosporin A | a specific pharmacological inhibitor of calcineurin. Cyclosporin A modulates cell shape and actin organization of melanoma cells | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | calcineurin is dependent on Ca2+/calmodulin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-168 cell | selected from A2058 cell line | Homo sapiens | - |
melanoma cell | - |
Homo sapiens | - |
WM-35 cell | established from a primary cutaneous melanoma of radial growth phase | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated protein phosphatase inhibitor-1 + H2O | - |
Homo sapiens | protein phosphatase inhibitor-1 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calcineurin | - |
Homo sapiens |
PP2B | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | partly malignancy-dependent role of calcineurin in melanoma cell lines, overview. Calcineurin-inhibiting compounds are applied for local treatment of psoriasis or atopic dermatitis | Homo sapiens |