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Literature summary for 3.4.24.80 extracted from

  • Ma, J.; Tang, X.; Wong, P.; Jacobs, B.; Borden, E.C.; Bedogni, B.
    Noncanonical activation of Notch1 protein by membrane type 1 matrix metalloproteinase (MT1-MMP) controls melanoma cell proliferation (2014), J. Biol. Chem., 289, 8442-8449.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Localization

Localization Comment Organism GeneOntology No. Textmining
cell membrane
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Notch1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50281
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-375.S2 cell
-
 Homo sapiens
-
C32-TG cell
-
 Homo sapiens
-
K-457 cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
melanoma cell line
-
 Homo sapiens
-
melanoma cell line UACC2521 Homo sapiens
-
melanoma cell line UACC2824 Homo sapiens
-
SK-MEL-2 cell
-
 Homo sapiens
-
SK-Mel-24 cell
-
 Homo sapiens
-
UACC-3291 cell
-
 Homo sapiens
-
WM-115 cell
-
 Homo sapiens
-
WM-266-4 cell
-
 Homo sapiens
-
WM-35 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Notch1 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
membrane type 1 matrix metalloproteinase
-
 Homo sapiens
MT1-MMP
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism an MT1-MMP/Notch1 signaling pathway supports melanoma cell growth Homo sapiens
physiological function the enzyme promotes Notch1 activation in melanoma cells Homo sapiens