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Information on EC 3.4.25.1 - proteasome endopeptidase complex

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3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.25 Threonine endopeptidases

3.4.25.1 proteasome endopeptidase complex

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3.4.25.1
bortezomib
myeloma
polyubiquitinated
neurodegenerative
misfolded
lysosomal
histone
chymotrypsin-like
ligases
leukemia
relapsed
nf-kappab
immunomodulatory
parkinsonism
lymphoma
deacetylase
ubiquitin-dependent
alzheimer
cyclins
hematologic
caspase
histocompatibility
proteostasis
ubiquitin-like
dexamethasone
hsp90
deubiquitinating
ubiquitin-conjugating
calpains
autologous
inclusions
incurable
cyclin-dependent
short-lived
mantle
trypsin-like
progression-free
thalidomide
ubiquitin-mediated
polyglutamine
ikappab
mcl-1
multisubunit
mdm2
ikappabalpha
parkin
rituximab
alpha-synuclein
single-agent
p27kip1
synthesis
medicine
degradation
analysis
drug development
biotechnology

The enzyme appears in viruses and cellular organisms

Reaction Schemes

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cleavage of peptide bonds with very broad specificity

Synonyms

proteasome, 26s proteasome, 20s proteasome, 26 s proteasome, multicatalytic proteinase, 20 s proteasome, multicatalytic protease, 26s proteasome complex, prosome, proteasome 20s, show all synonyms

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

20 S proteasome

2 entries

206 proteasome

Arabidopsis thaliana

the 26S proteasome is composed of the 20S and the 19S complex

20S CP

20S protease core

20S proteasome

26 S proteasome

26S protease

26S proteasome

15 entries

26S proteasome complex

Homo sapiens

685141

27 kDa prosomal protein

30 kDa prosomal protein

beta1-PF1404

c20S

Component Y8

constitutive proteasome 20S

Homo sapiens

711577

EC 3.4.22.21

formerly

EC 3.4.24.5

formerly, part transferred

EC 3.4.99.46

formerly

GPRO-28

HsBPROS26

HSN3

i20S

immunoproteasome 20S

ingensin

KIPase

Homo sapiens

684688

large multicatalytic protease

macropain

multi-subunit protease complex

Homo sapiens

711441

multicatalytic endopeptidase complex

Multicatalytic endopeptidase complex C7

multicatalytic protease

multicatalytic proteinase

2 entries

p27K

PROS-27

PROS-30

PROS-Dm25

PROS-Dm28.1

PROS-Dm29

PROS-Dm35

Pros26.4

Drosophila melanogaster

member of the AAA-ATPase subunits of the proteasome 19S regulatory particle

669590

prosome

proteasome

5 entries

proteasome 19S

Drosophila melanogaster

669590

proteasome 20S

Homo sapiens

712705

Proteasome component C13

Proteasome component C2

Proteasome component C3

Proteasome component C5

Proteasome component C8

Proteasome component C9

Proteasome component DD4

Proteasome component DD5

Proteasome component pts1

proteasome subunit alpha-type 7-like

PSMA5

alpha5 subunit of the 20S proteasome

Psma8

RING12 protein

RN3

Scl1

Saccharomyces cerevisiae

P21243

755543

SCL1 suppressor protein

SFRICE_003436

Spodoptera frugiperda

A0A2H1WB52

752830

T20S

Thermoplasma acidophilum

P25156; P28061

733715

TAS-F22/FAFP98

TAS-G64

TCPR29

tricorn protease

tricorn proteinase

XC3

20 S proteasome

Homo sapiens

712414

20 S proteasome

Thermoplasma acidophilum

20S CP

20S CP

20S CP

Methanocaldococcus jannaschii

718975

20S CP

Mycobacterium tuberculosis

718975

20S CP

Saccharomyces cerevisiae

718975

20S CP

Saccharomyces cerevisiae

P21243

core particle of the proteasome 20S

734683

20S CP

Thermoplasma acidophilum

20S protease core

20S protease core

20S protease core

Methanocaldococcus jannaschii

718975

20S protease core

Mycobacterium tuberculosis

718975

20S protease core

Saccharomyces cerevisiae

718975

20S protease core

Thermoplasma acidophilum

718975

20S proteasome

Bos taurus

650040, 651329, 685443

20S proteasome

20S proteasome

20S proteasome

652378, 684688, 687645, 688376, 688495, 702678, 707667, 711380, 711621, 711673, 711844, 711902, 712551, 712705, 712918, 713407, 713585, 733663

20S proteasome

Homo sapiens

P25789

735293

20S proteasome

Methanocaldococcus jannaschii

653784

20S proteasome

Methanosarcina thermophila

733997

20S proteasome

Mus musculus

688760, 711673

20S proteasome

Oryctolagus cuniculus

20S proteasome

20S proteasome

20S proteasome

650428, 684668, 685897, 686124, 711621, 711690

20S proteasome

Saccharomyces cerevisiae

652508, 687645, 688337, 690086

20S proteasome

20S proteasome

20S proteasome

Tritrichomonas foetus

A0A075KK20

the catalytic core of the 26S proteasome is a 700 kDa multi-subunit threonine protease known as 20S proteasome

20S proteasome

26 S proteasome

26 S proteasome

26 S proteasome

26S proteasome

26S proteasome

669302, 670536, 689546

26S proteasome

Capsicum annuum

667451

26S proteasome

Drosophila melanogaster

668730

26S proteasome

Drosophila melanogaster

Q9V3P6

652599

26S proteasome

Homo sapiens

669939, 684864, 684965, 685565, 685994, 689288, 711074, 711673, 711844, 712551, 712918, 713032

26S proteasome

Homo sapiens

the 26S proteasome is a large multisubunit complex containing a 20S proteolytic core particle and a 19S regulatory particle

689983

26S proteasome

Homo sapiens

the 26S proteasomes consist of a catalytic 20S core and two 19S regulatory complexes

688404

26S proteasome

Mus musculus

686716, 688760, 711673, 713032

26S proteasome

Oryctolagus cuniculus

652508, 685936

26S proteasome

Petunia integrifolia subsp. inflata

689545

26S proteasome

Phlebia radiata

686442

26S proteasome

Saccharomyces cerevisiae

26S proteasome

26S proteasome

multicatalytic proteinase

Thermoplasma acidophilum

P28061; P25156

747051

proteasome

Homo sapiens

702678, 707667, 711380, 711441, 711621, 711671, 711673, 712388, 712414, 712549, 712705, 712918, 713032, 713341, 713407, 713585

proteasome

Mus musculus

711082, 711673, 711942, 712388, 712637, 713032, 713551

proteasome

Phaseolus vulgaris

711082

proteasome

Rattus norvegicus

711354, 711621, 711690, 712388

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

cleavage of peptide bonds with very broad specificity

11 entries

cleavage of peptide bonds with very broad specificity

mechanism

Thermoplasma acidophilum

137354, 137356, 137364

cleavage of peptide bonds with very broad specificity

chymotrypsin-like activity and peptidylglutamyl peptide hydrolase activity

Methanosarcina thermophila

137329

cleavage of peptide bonds with very broad specificity

ATPase activity

Homo sapiens

137364

cleavage of peptide bonds with very broad specificity

ATPase activity

Saccharomyces cerevisiae

137364

cleavage of peptide bonds with very broad specificity

Staphylococcus aureus V8 protease like activity

Spinacia oleracea

137335

cleavage of peptide bonds with very broad specificity

peptidylglutamyl peptide hydrolase, chymotrypsin-like and trypsin-like activities

Struthio camelus

137351

cleavage of peptide bonds with very broad specificity

chymotrypsin-like activity

Rhodococcus sp.

137346

cleavage of peptide bonds with very broad specificity

chymotrypsin-like, trypsin-like and V8 protease like activities

Psophocarpus tetragonolobus

137345

cleavage of peptide bonds with very broad specificity

trypsin-like, chymotrypsin-like activities, peptidylglutamyl peptide hydrolase and branched-chain amino acid preferring and caseinolytic activities

Manduca sexta

137332

cleavage of peptide bonds with very broad specificity

ATPase activity, chymotrypsin-like activity, trypsin-like activity

Spinacia oleracea

137334

cleavage of peptide bonds with very broad specificity

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

hydrolysis of peptide bond

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CAS REGISTRY NUMBER

COMMENTARY

140879-24-9

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

1-aminocyclopropane-1-carboxylic acid synthase 6 + H2O

Arabidopsis thaliana

phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase 6 introduces negative charges to the C-terminus of ACS6, which reduces the turnover of 1-aminocyclopropane-1-carboxylic acid synthase 6 by the 26S proteasome degradation machinery

689546

4-hydroxy-3-nitrophenol-Leu-Leu-Asn-vinylsulfone + H2O

Trypanosoma brucei

O96780, O96787, O96788, Q9BMX8, Q9GU36, Q9GU37, Q9NDA1, Q9NDA2, Q9NDA3, Q9NHC5, Q9NHC6, Q9U793, Q9U794, Q9XZG5

652378

4-hydroxy-3-nitrophenyl-Leu-Leu-Lys-vinylsulfone + H2O

Trypanosoma brucei

O96780, O96787, O96788, Q9BMX8, Q9GU36, Q9GU37, Q9NDA1, Q9NDA2, Q9NDA3, Q9NHC5, Q9NHC6, Q9U793, Q9U794, Q9XZG5

652378

AAF-7-amido-4-methylcoumarin + H2O

Rattus norvegicus

highest activity in testicle, kidney and brain

649426

ABZ-Val-Val-Ser-Arg-Ser-Leu-Gly-Tyr(3-NO2)-NH2 + H2O

Homo sapiens

synthetic, internally quenched substrate

752469

acetyl-Ala-Pro-norleucine-Leu-Leu-7-amido-4-methylcoumarin + H2O

acetyl-Ala-Pro-norleucine-Leu-Leu + 7-amino-4-methylcoumarin

2 entries

acetyl-Arg-hSer-Thr-Arg-7-amido-4-methylcoumarin + H2O

acetyl-Arg-hSer-Thr-Arg + 7-amino-4-methylcoumarin

Homo sapiens

substrate for trypsin-like activity

754398

acetyl-betaAla-Met(sulfone)-Thr-Arg-7-amido-4-methylcoumarin + H2O

acetyl-betaAla-Met(sulfone)-Thr-Arg + 7-amino-4-methylcoumarin

Homo sapiens

substrate for trypsin-like activity

754398

acetyl-DPSD-7-amido-4-methylcoumarin + H2O

Homo sapiens

cleaved by the beta1 subunit of the 20S proteasome

684688

acetyl-EPFD-7-amido-4-carbamoylcoumarin + H2O

2 entries

acetyl-GPLD-7-amido-4-methylcoumarin + H2O

acetyl-GPLD + 7-amino-4-methylcoumarin

2 entries

acetyl-GPLE-7-amido-4-methylcoumarin + H2O

acetyl-GPLE + 7-amino-4-methylcoumarin

2 entries

acetyl-GPLL-7-amido-4-methylcoumarin + H2O

acetyl-GPLL + 7-amino-4-methylcoumarin

2 entries

acetyl-hArg-Pro-2-fluoro-Phe-Asp-7-amido-4-methylcoumarin + H2O

acetyl-hArg-Pro-2-fluoro-Phe-Asp + 7-amino-4-methylcoumarin

Homo sapiens

substrate for caspase-like activity

754398

acetyl-hArg-Pro-Abu-Asp-7-amido-4-methylcoumarin + H2O

acetyl-hArg-Pro-Abu-Asp + 7-amino-4-methylcoumarin

Homo sapiens

substrate for caspase-like activity

754398

acetyl-HHSL-7-amido-4-carbamoylcoumarin + H2O

Homo sapiens

652378

acetyl-norleucine-Arg-norleucine-Arg-7-amido-4-carbamoylcoumarin + H2O

2 entries

acetyl-norleucine-Leu-Pro-norleucine-Leu-YVAD-7-amido-4-methylcoumarin + H2O

acetyl-norleucine-Leu-Pro-norleucine-Leu-YVAD + 7-amino-4-methylcoumarin

2 entries

acetyl-Phe-Thr(Bzl)-His(3-benzyloxymethyl)-Leu-7-amido-4-methylcoumarin + H2O

acetyl-Phe-Thr(Bzl)-His(3-benzyloxymethyl)-Leu + 7-amino-4-methylcoumarin

Homo sapiens

substrate for chymotrypsin-like activity

754398

acetyl-YVAD-7-amido-4-methylcoumarin + H2O

acetyl-YVAD + 7-amino-4-methylcoumarin

2 entries

acetyl-YWTQ-7-amido-4-carbamoylcoumarin + H2O

2 entries

Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O

3 entries

Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O

Ala-Ala-Phe + 7-amino-4-methylcoumarin

Mus musculus

711942

Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O

Methanosarcina thermophila

137329

benzoyl-LRR-4-methyl-7-amido-coumarin + H2O

benzoyl-LRR + 4-methyl-7-amino-coumarin

2 entries

benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O

Methanosarcina thermophila

137329

benzoyl-VGR-4-methyl-7-amido-coumarin + H2O

benzoyl-VGR + 4-methyl-7-amino-coumarin

Rattus norvegicus

trypsin-like proteasome activity

711690

benzoyl-VGR-7-amido-4-methylcoumarin + H2O

Rattus norvegicus

650428

benzyl-Val-Gly-Arg-7-amido-4-methylcoumarin + H2O

Saccharomyces cerevisiae

690086

benzyloxycarbonyl-Ala-Ala-Leu-4-nitroanilide + H2O

Methanocaldococcus jannaschii

653784

benzyloxycarbonyl-Ala-Arg-Arg-Arg-7-amido-4-methylcoumarin + H2O

Saccharomyces cerevisiae

670135

benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O

Trypanosoma brucei

137344

benzyloxycarbonyl-ARR-7-amido-4-methylcoumarin + H2O

Struthio camelus

650467

benzyloxycarbonyl-D-Ala-Leu-Arg-4-nitroanilide + H2O

Bos taurus

653723

benzyloxycarbonyl-dALR-2-naphthylamide + H2O

Bos taurus

650040

benzyloxycarbonyl-FR-7-amido-4-methylcoumarin + H2O

Struthio camelus

650467

benzyloxycarbonyl-GAPLG-p-aminobenzoate + H2O

Bos taurus

653723

benzyloxycarbonyl-GGF-4-aminobenzoate + H2O

Bos taurus

653723

benzyloxycarbonyl-GGF-p-aminobenzoate + H2O

Bos taurus

653723

benzyloxycarbonyl-GGL-2-naphthylamide + H2O

Bos taurus

653723

benzyloxycarbonyl-GGL-4-nitroanilide + H2O

Candida albicans

chymotrypsin-like activity

649428

benzyloxycarbonyl-GGL-7-amido-4-methylcoumarin + H2O

benzyloxycarbonyl-GGL + 7-amino-4-methylcoumarin

Struthio camelus

650467

benzyloxycarbonyl-GGR-2-naphthylamide + H2O

Candida albicans

trypsin-like activity

649428

benzyloxycarbonyl-GGR-7-amido-4-methylcoumarin + H2O

2 entries

benzyloxycarbonyl-Gly-Gly-Arg-beta-naphthylamide + H2O

Manduca sexta

137332

benzyloxycarbonyl-Gly-Gly-Leu-4-nitroanilide + H2O

Bos taurus

651329

benzyloxycarbonyl-Gly-Gly-Leu-7-amido-4-methylcoumarin + H2O

4 entries

benzyloxycarbonyl-Gly-Gly-Leu-p-nitroanilide + H2O

2 entries

benzyloxycarbonyl-Gly-Pro-Ala-Gly-Gly-p-aminobenzoate + aminopeptidase-N + H2O

Manduca sexta

137332

benzyloxycarbonyl-Gly-Pro-Ala-Leu-Ala-p-aminobenzoate + aminopeptidase-N + H2O

Manduca sexta

137332

benzyloxycarbonyl-GPAFG-4-aminobenzoate + H2O

Bos taurus

653723

benzyloxycarbonyl-GPAFG-p-aminobenzoate + H2O

Bos taurus

653723

benzyloxycarbonyl-GPAGG-4-aminobenzoate + H2O

Rattus norvegicus

highest activity in soleus and brain

649426

benzyloxycarbonyl-GPAGG-4-nitroanilide + H2O

Bos taurus

653723

benzyloxycarbonyl-GPALG-4-aminobenzoate + H2O

3 entries

benzyloxycarbonyl-GPALG-p-aminobenzoate + H2O

Bos taurus

653723

benzyloxycarbonyl-LAF-4-aminobenzoate + H2O

Bos taurus

650040

benzyloxycarbonyl-Leu-Leu-Glu-2-naphthylamide + H2O

Saccharomyces cerevisiae

670135

benzyloxycarbonyl-Leu-Leu-Glu-7-amido-4-methylcoumarin + H2O

Patiria pectinifera

11% of the activity with succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin

650902

benzyloxycarbonyl-Leu-Leu-Glu-beta-naphthylamide + H2O

5 entries

benzyloxycarbonyl-Leu-Leu-Leu-7-amido-4-methylcoumarin + H2O

Patiria pectinifera

36% of the activity with succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin

650902

benzyloxycarbonyl-LLE-2-naphthylamide + H2O

5 entries

benzyloxycarbonyl-LLE-7-amido-4-methylcoumarin + H2O

Rattus norvegicus

650428

benzyloxycarbonyl-LLE-beta-naphthylamide + H2O

Phlebia radiata

caspase-like activity

686442

benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O

Trypanosoma brucei

137344

benzyloxycarbonyl-RR-7-amido-4-methylcoumarin + H2O

beta-casein + H2O

Boc-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O

2 entries

Boc-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O

Boc-Leu-Arg-Arg + 7-amino-4-methylcoumarin

3 entries

Boc-Leu-Leu-Glu-4-methylcoumarin-7-amide + H2O

Boc-Leu-Leu-Glu + 7-amino-4-methylcoumarin

Homo sapiens

755477

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin + H2O

Boc-Leu-Ser-Thr-Arg + 7-amino-4-methylcoumarin

Mus musculus

711942

Bz-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O

Homo sapiens

685994

Bz-DL-Arg-7-amido-4-methylcoumarin + H2O

Homo sapiens

685994

Bz-VGR-7-amido-4-methylcoumarin + H2O

casein + H2O

DBC2 protein + H2O

dihydrofolate reductase + H2O

2 entries

ERM transcription factor + H2O

Homo sapiens

689288

erythroid Krueppel-like factor + H2O

Mus musculus

686716

fructose-1,6-bisphosphatase + H2O

Saccharomyces cerevisiae

137359

Glu-Gly-Gly-7-amido-4-methylcoumarin + H2O

Thermoplasma acidophilum

137361

Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O

2 entries

H-VLK-7-amido-4-methylcoumarin + H2O

Struthio camelus

very-low activity

650467

hepatitis B virus X protein + H2O

IGF-1 + H2O

IkappaBalpha + H2O

can be directly degraded by 20S proteasomes. Deletion constructs of IkappaBalpha allow us to the determine that N-terminal (DELTA1-70)and C-terminal regions (DELTA280-327, removing the PEST region) of IkappaBalpha are not required for IkappaBalpha degradation,while a further C-terminal deletion including part of the arm repeats (DELTAC2 245-327) almost completely suppress the degradation by 20S proteasome. Degradation of IkappaBalpha involves specific interactions with a C3 subunit of the proteasome

668615

Ile-Ile-Trp-7-amido-4-methylcoumarin + H2O

Methanosarcina thermophila

Leu-Arg-Arg + H2O

Leu-Leu-Glu + H2O

Leu-Leu-Val-Tyr + H2O

Hepatitis B virus

137353

Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O

Methanosarcina thermophila

137329

MATalpha2 repressor + H2O

Saccharomyces cerevisiae

137359

methyl-casein + H2O

Allium sativum

669016

morpholinoacetyl-homophenylalanyl-methylseryl-thienylalanyl-7-amido-4-carbamoylmethylcoumarin + H2O

morpholinoacetyl-homophenylalanine-methylserine-thienylalanine + 7-amino-4-carbamoylmethylcoumarin

2 entries

N-Cbz-Leu-Leu-Glu-beta-naphthylamide + H2O

Rattus norvegicus

684668

N-methoxysuccinyl-Glu-Val-Lys-Met-p-nitroanilide + H2O

Homo sapiens

137356

N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O

3 entries

N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O

N-succinyl-LLVY + 7-amino-4-methylcoumarin

4 entries

N-succinyl-LLVY-aminoluciferin + H2O

Homo sapiens

733663

N-t-Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin + H2O

Rattus norvegicus

684668

N-tert-butyloxycarbonyl-LSTR-7-amido-4-methylcoumarin + H2O

Rattus norvegicus

highest activity in kidney

649426

ovalbumin + H2O

Homo sapiens

688404

oxidized insulin B chain + H2O

p27(KIP1) + H2O

Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O

Methanosarcina thermophila

137329

PS1/gamma-secretase complex component + H2O

2 entries

S-RNase + H2O

Petunia integrifolia subsp. inflata

S-RNase is ubiquitinated and degraded by the 26S proteasome

689545

Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O

7-amino-4-methylcoumarin + Suc-Leu-Leu-Val-Tyr

Mus musculus

711082

Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O

2 entries

succinyl-AAF-7-amido-4-methylcoumarin + H2O

Struthio camelus

650467

succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O

4 entries

succinyl-Ile-Ile-Trp-7-amido-4-methylcoumarin + H2O

Methanosarcina thermophila

137329

succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin-7-amide + H2O

succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin

Homo sapiens

755477

succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O

18 entries

succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O

succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin

7 entries

succinyl-Leu-Met-7-amido-4-methylcoumarin + H2O

Rattus norvegicus

137343

succinyl-LLVY-7-amido-4-methylcoumarin + H2O

succinyl-LLVY + 7-amino-4-methylcoumarin

Struthio camelus

650467

succinyl-LLVY-aminoluciferin + H2O

succinyl-LLVY + aminoluciferin

3 entries

t-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin + H2O

2 entries

t-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O

2 entries

tert-butyloxycarbonyl-Leu-Arg-Arg-4-methylcoumarin-7-amide

Homo sapiens

755477

tert-butyloxycarbonyl-LRR-7-amido-4-methylcoumarin + H2O

Struthio camelus

650467

tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O

Patiria pectinifera

65% of the activity with succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin

650902

Tyr-Leu-Leu-Leu-vinylsulfone + H2O

Trypanosoma brucei

O96780, O96787, O96788, Q9BMX8, Q9GU36, Q9GU37, Q9NDA1, Q9NDA2, Q9NDA3, Q9NHC5, Q9NHC6, Q9U793, Q9U794, Q9XZG5

652378

Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin + H2O

Methanosarcina thermophila

137329

ubiquitinylated proteins

7 entries

unstable green fluorescence protein + H2O

Homo sapiens

artificial substrate for the proteasome. The model proteasomal substrate is stabilized by the carboxyl-terminal half of S5a, S5aC

711074

Z-Ala-Arg-Arg-7-amido-4-methylcoumarin + H2O

Mus musculus

688760

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin + H2O

Z-Leu-Leu-Glu + 7-amino-4-methylcoumarin

3 entries

Z-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O

Z-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin

2 entries

All organisms
Allium sativum
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