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Literature summary for 5.6.2.1 extracted from

  • Kurtzberg, L.S.; Roth, S.; Krumbholz, R.; Crawford, J.; Bormann, C.; Dunham, S.; Yao, M.; Rouleau, C.; Bagley, R.G.; Yu, X.J.; Wang, F.; Schmid, S.M.; Lavoie, E.J.; Teicher, B.A.
    Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment (2011), Clin. Cancer Res., 17, 2777-2787.
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
(S)-camptothecin
-
 Homo sapiens
(S)-camptothecin
-
 Mus musculus
8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one i.e. ARC-111 Homo sapiens
8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one i.e. ARC-111 Mus musculus
8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one i.e. Genz-644282 Homo sapiens
8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one i.e. Genz-644282 Mus musculus
additional information topoisomerase I inhibitors act as anticancer drugs, overview. Bone marrow colony-forming unit, CFU, granulocyte macrophage CFU, and tumor cell CFU activity of topoisomerase I inhibitors, overview. CFU are bipotent hemopoietic stem cells. Human bone marrow colony-forming unit is more sensitive to the Top1 inhibitors than is mouse bone marrow colony-forming unit Homo sapiens
additional information topoisomerase I inhibitors act as anticancer drugs, overview. Bone marrow colony-forming unit, CFU, granulocyte macrophage CFU, and tumor cell CFU activity of topoisomerase I inhibitors, overview. CFU are bipotent hemopoietic stem cells. Human bone marrow colony-forming unit is more sensitive to the Top1 inhibitors than is mouse bone marrow colony-forming unit Mus musculus
SN-38
-
 Homo sapiens
SN-38
-
 Mus musculus
topotecan
-
 Homo sapiens
topotecan
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 male mice
-
Mus musculus BALB/c
-
 male mice
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow cell
-
 Mus musculus
-
bone marrow cell
-
 Homo sapiens
-
colonic cancer cell
-
 Homo sapiens
-
DLD-1 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
HCT-15 cell
-
 Homo sapiens
-
hematopoietic stem cell bipotent hemopoietic stem cells Mus musculus
-
hematopoietic stem cell bipotent hemopoietic stem cells Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
KB-3-1 cell
-
 Homo sapiens
-
KB-V1 cell
-
 Homo sapiens
-
KBH5.0 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
non-small cell lung cancer cell
-
 Homo sapiens
-
RCC 786-O cell
-
 Homo sapiens
-
renal cell carcinoma cell
-
 Homo sapiens
-
RPMI-8226 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Top1
-
 Mus musculus
Top1
-
 Homo sapiens
Topoisomerase I
-
 Mus musculus
Topoisomerase I
-
 Homo sapiens