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Information on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase

for references in articles please use BRENDA:EC2.3.2.5

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IUBMB Comments

Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
glutaminyl cyclase, isoqc, qpctl, glutaminyl-peptide cyclotransferase, isodromeqc, glutamine cyclotransferase, dromeqc, golgi resident enzyme, golgi-resident enzyme, h-isoqc, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
5-oxo-L-proline metabolism