EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
melanoma cell |
high expression level |
735601 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
melanoma cell |
- |
721967 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
melanoma cell |
- |
760802 |
2.8.1.2 | 3-mercaptopyruvate sulfurtransferase |
melanoma cell |
- |
713731 |
3.1.3.5 | 5'-nucleotidase |
melanoma cell |
- |
677542 |
7.4.2.14 | ABC-type antigen peptide transporter |
melanoma cell |
- |
761911 |
1.13.11.53 | acireductone dioxygenase (Ni2+-requiring) |
melanoma cell |
- |
764226 |
3.4.24.81 | ADAM10 endopeptidase |
melanoma cell |
- |
668181 |
3.4.24.B28 | ADAM15 |
melanoma cell |
melanocytes and endothelial cells of benign nevi and melanoma tissue |
718739 |
3.4.24.B9 | ADAM9 endopeptidase |
melanoma cell |
ADAM-9 is expressed in human melanoma at the tumor-stroma border where direct or indirect interactions between tumor cells and fibroblasts occur |
719997 |
4.1.1.50 | adenosylmethionine decarboxylase |
melanoma cell |
- |
4690 |
2.7.1.147 | ADP-specific glucose/glucosamine kinase |
melanoma cell |
- |
723169 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
melanoma cell |
- |
696397 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
melanoma cell |
secrets the mature ATX |
713665 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
melanoma cell |
- |
735724 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
melanoma cell |
parental mouse melanoma cell S91 6neo |
688812, 693954 |
3.2.1.24 | alpha-mannosidase |
melanoma cell |
- |
665978 |
5.1.99.4 | alpha-methylacyl-CoA racemase |
melanoma cell |
- |
749413 |
3.2.1.49 | alpha-N-acetylgalactosaminidase |
melanoma cell |
cutaneous melanoma, specific enzymatic activity of serum alpha-N-acetylgalactosaminidase is significantly increased in stage III melanoma patients, but not in early stages |
707963 |
2.4.3.8 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase |
melanoma cell |
- |
735601, 764085, 764812 |
7.3.2.7 | arsenite-transporting ATPase |
melanoma cell |
- |
697072 |
7.4.2.5 | bacterial ABC-type protein transporter |
melanoma cell |
- |
700137 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
melanoma cell |
GCNT3 is overexpressed in highly metastatic melanomas |
759882 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
melanoma cell |
- |
688812, 735724, 759316 |
2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase |
melanoma cell |
- |
637260 |
1.14.15.18 | calcidiol 1-monooxygenase |
melanoma cell |
- |
659811 |
3.4.22.52 | calpain-1 |
melanoma cell |
- |
709406 |
3.4.22.54 | calpain-3 |
melanoma cell |
- |
708013 |
3.4.22.36 | caspase-1 |
melanoma cell |
- |
709153 |
3.4.22.56 | caspase-3 |
melanoma cell |
- |
700600 |
3.4.22.56 | caspase-3 |
melanoma cell |
expression patterns of the major caspases, CASP3, 6, 7, 8, 9, and 10, and inhibitor of apoptosis proteins, survivin, CIAP1, CIAP2, XIAP, and livin, overview |
698197 |
3.4.22.61 | caspase-8 |
melanoma cell |
expression patterns of the major caspases, CASP3, 6, 7, 8, 9, and 10, and inhibitor of apoptosis proteins, survivin, CIAP1, CIAP2, XIAP, and livin, overview |
698197 |
3.4.22.1 | cathepsin B |
melanoma cell |
- |
681195, 753138 |
3.4.22.38 | cathepsin K |
melanoma cell |
immunostaining reveals strong catK expression in most primary melanomas and all cutaneous melanoma metastases. Melanocytic nevi also demonstrates catK expression, but it is less intense than in melanomas. Melanoma lines express both the pro- and the active form of catK |
681252 |
3.4.22.15 | cathepsin L |
melanoma cell |
- |
696091, 712921 |
3.4.22.15 | cathepsin L |
melanoma cell |
cathepsin L activity was detected in the cell culture supernatant by lithium dodecyl sulfate gelatin zymography |
667194 |
3.4.22.43 | cathepsin V |
melanoma cell |
- |
752678 |
3.5.1.23 | ceramidase |
melanoma cell |
- |
735256 |
3.5.1.23 | ceramidase |
melanoma cell |
human melanoma biopsies reveal heterogeneous staining of ASAH1 and low ASAH1 expression at the melanoma invasive front. ASAH1 is highly expressed and active in about 60% of melanoma cells, and its expression correlates with that of MITF |
754939 |
2.4.1.80 | ceramide glucosyltransferase |
melanoma cell |
- |
735591 |
2.7.11.22 | cyclin-dependent kinase |
melanoma cell |
- |
665840 |
2.7.1.107 | diacylglycerol kinase (ATP) |
melanoma cell |
- |
672420 |
2.7.1.107 | diacylglycerol kinase (ATP) |
melanoma cell |
expression of isoform diacylglycerol kinase alpha in several melanoma cell lines but not in noncancerous melanocytes |
672420 |
1.5.1.3 | dihydrofolate reductase |
melanoma cell |
DHFR is overexpressed in melanoma cells |
705800 |
3.4.14.5 | dipeptidyl-peptidase IV |
melanoma cell |
- |
703784 |
4.1.1.33 | diphosphomevalonate decarboxylase |
melanoma cell |
B16F10 |
650501 |
5.6.2.1 | DNA topoisomerase |
melanoma cell |
- |
714760 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
melanoma cell |
- |
726691 |
2.7.11.20 | elongation factor 2 kinase |
melanoma cell |
- |
760309 |
3.4.21.53 | Endopeptidase La |
melanoma cell |
- |
731618 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
melanoma cell |
minor splice isozyme PFKFB-4, major isozyme is PFKFB-3 |
666334 |
3.4.21.75 | Furin |
melanoma cell |
- |
753199 |
2.3.2.2 | gamma-glutamyltransferase |
melanoma cell |
GGT-overexpression in melanoma cells is associated with resistance to oxidative stress produced by prooxidant agents such as hydrogen peroxide and ascorbic acid |
686496 |
3.4.24.24 | gelatinase A |
melanoma cell |
- |
684054, 752865 |
5.3.1.9 | glucose-6-phosphate isomerase |
melanoma cell |
- |
704574 |
2.4.1.274 | glucosylceramide beta-1,4-galactosyltransferase |
melanoma cell |
- |
736198 |
6.3.2.2 | glutamate-cysteine ligase |
melanoma cell |
gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells |
676099 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
melanoma cell |
- |
759839 |
1.7.1.7 | GMP reductase |
melanoma cell |
expression of guanosine monophosphate reductase (GMPR), an enzyme involved in de novo biosynthesis of purine nucleotides, is downregulated in invasive stages of human melanoma. From 9 arbitrarily chosen human metastatic melanoma cell lines, GMPR is expressed in only one cell line |
742245 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
melanoma cell |
- |
685815 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
melanoma cell |
quantitative HO-1 expression analysis |
687181 |
2.3.3.10 | hydroxymethylglutaryl-CoA synthase |
melanoma cell |
although HMGCS1 expression does not correlate with BRAFV600E mutation in human melanoma cells, HMGCS1 is selectively important for proliferation of BRAFV600E-positive melanoma and colon cancer cells but not control cells harboring activeN/KRAS mutants, and stable knockdown of HMGCS1 only attenuated colony formation and tumor growth potential of BRAFV600E melanoma cells |
757174 |
3.4.24.56 | insulysin |
melanoma cell |
- |
668184 |
3.4.24.7 | interstitial collagenase |
melanoma cell |
of invasive melanomas |
683330 |
3.4.24.7 | interstitial collagenase |
melanoma cell |
VMM5 cells, VMM12cells and VMM39. Constitutive overexpression of collagenase 1 is mediated by the ERK pathway in invasive melanoma cells |
669246 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
melanoma cell |
- |
711107 |
3.4.21.61 | Kexin |
melanoma cell |
- |
732728 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
- |
648805, 648814, 748797 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
B16 |
648811, 648812 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
B16 melanoma |
648815 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
B16/F10 |
648807 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
Cloudman mouse melanoma cells |
648804 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
Cloudman mouse melanoma cells (S91) |
648809 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
levels of DCT are elevated in melanoma cell lines that are especially resistant to chemotherapy and radiation |
706613 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
melan-a, melan-b, melan-c melanocytes |
648817 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
of neural crest origin |
648813 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
WM35 cell line |
648819 |
2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase |
melanoma cell |
- |
736209, 764220 |
4.4.1.5 | lactoylglutathione lyase |
melanoma cell |
- |
709815 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
melanoma cell |
- |
761332 |
3.4.24.23 | matrilysin |
melanoma cell |
primary cutaneous and metastatic melanoma |
683312 |
3.4.24.B4 | matrix metalloproteinase-13 |
melanoma cell |
- |
650906, 720440 |
3.4.24.B4 | matrix metalloproteinase-13 |
melanoma cell |
cutaneous malignant melanoma |
668973 |
3.4.24.B7 | matrix metalloproteinase-26 |
melanoma cell |
elevated MMP-26 expression level |
710794 |
3.4.11.2 | membrane alanyl aminopeptidase |
melanoma cell |
- |
35865, 664466, 665112 |
3.4.24.80 | membrane-type matrix metalloproteinase-1 |
melanoma cell |
- |
734297 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
melanoma cell |
- |
705661 |
2.7.12.2 | mitogen-activated protein kinase kinase |
melanoma cell |
- |
740419 |
2.7.12.2 | mitogen-activated protein kinase kinase |
melanoma cell |
choroidal from eyes, and cutaneous |
665489 |
2.4.1.90 | N-acetyllactosamine synthase |
melanoma cell |
Bowes melanoma cell line |
658123 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
melanoma cell |
- |
487039 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
melanoma cell |
sialic acid O-acetylation levels in different samples, overview |
677235 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
melanoma cell |
- |
-, 725514, 742841 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
melanoma cell |
- |
746204 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
melanoma cell |
- |
742556 |
3.4.24.16 | neurolysin |
melanoma cell |
- |
-, 754898 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
melanoma cell |
- |
735872, 760200 |
2.7.10.2 | non-specific protein-tyrosine kinase |
melanoma cell |
elevated levels of malignant cells |
490359 |
2.7.11.1 | non-specific serine/threonine protein kinase |
melanoma cell |
- |
662601 |
4.1.1.17 | ornithine decarboxylase |
melanoma cell |
- |
677508 |