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6-phosphofructo-2-kinase/2,6-bisphosphatase 3
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6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
6-phosphofructo-2-kinase/fructose-2,6-bisphosphase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (gene PFKFB3)
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bifunctional enzyme
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4
6-phosphofructo-2-kinase/fructose-2,6-bisphosphate
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D-fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
fructose-2,6-diphosphatase
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heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
PFKFB-3
isoform, bifunctional enzyme possessing 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase activities
PFKFB-4
isoform, bifunctional enzyme
phosphatase, fructose 2,6-di-
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6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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bifunctional enzyme
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4
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F2KP
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FBPase
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FBPase-2
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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Pfk-2
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PFK-2/FBPase-2
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PFK-2/FDPase-2
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PFK2
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PFK2
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bifunctional enzyme
PFKFB
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PFKFB1
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PFKFB2
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PFKFB3
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PFKFB4
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additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
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bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
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bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
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cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
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cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
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bifunctional enzyme, cf. EC 2.7.1.105
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
mechanism
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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94925, 94932, 94933, 94934, 94935, 94939, 94940, 94941, 94942, 94944, 94945, 94948, 94952
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
Pigeon
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
mechanism, kinetic model
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
mechanism, regulation
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
catalytic phosphorylation of His residues is essential, overview
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
catalytic site structure and interactions involving residues H258, E327, H392, R397, and H446, detailed molecular mechanism and regulation in wild-type and mutant enzymes, overview, catalytic phosphorylation of His residues is essential, overview
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
substrate binding loop structure and regulation mechanism, interactions of enzyme and substrate involve residues K47, R74, R75, R98, and T126, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
beta-D-fructose 2,6-bisphosphate induces a global conformational change in the absence of AMP
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
in-line phosphoryl transfer initiated by a substrate-assisted mechanism
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
the complex of E. coli FBPase with beta-D-fructose 2,6-bisphosphate remains in the R-state with dynamic loops in the engaged conformation
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beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
fructose 2,6-bisphosphate + H2O
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fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
additional information
?
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beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB1
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB2
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB3
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB1
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB2
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB3
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB4
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: regulation mechanism, overview
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition
Products: -
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beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: substrate binding loop structure, overview
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB2
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB3
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB1
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB2
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: metabolic regulation of isozyme PFKFB4
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: -
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
Products: -
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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Substrates: -
Products: -
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: -
Products: -
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
Substrates: -
Products: -
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
Substrates: -
Products: -
?
fructose 2,6-bisphosphate + H2O
?
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Substrates: -
Products: -
?
fructose 2,6-bisphosphate + H2O
?
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Substrates: -
Products: -
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fructose 2,6-bisphosphate + H2O
?
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Substrates: -
Products: -
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fructose 2,6-bisphosphate + H2O
?
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Substrates: -
Products: -
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fructose 2,6-bisphosphate + H2O
?
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Substrates: -
Products: -
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fructose 2,6-bisphosphate + H2O
?
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Substrates: -
Products: -
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fructose 2,6-bisphosphate + H2O
?
Pigeon
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Substrates: -
Products: -
?
fructose 2,6-bisphosphate + H2O
?
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94925, 94932, 94933, 94934, 94935, 94939, 94940, 94941, 94942, 94944, 94945, 94948, 94952 Substrates: -
Products: -
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fructose 2,6-bisphosphate + H2O
?
Substrates: -
Products: -
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fructose 2,6-bisphosphate + H2O
?
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Substrates: -
Products: -
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fructose 2,6-bisphosphate + H2O
?
Substrates: -
Products: -
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fructose 2,6-bisphosphate + H2O
?
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Substrates: -
Products: -
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