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6-phosphofructo-2-kinase/2,6-bisphosphatase 3
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6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
6-phosphofructo-2-kinase/fructose-2,6-bisphosphase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (gene PFKFB3)
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bifunctional enzyme
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4
6-phosphofructo-2-kinase/fructose-2,6-bisphosphate
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D-fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
fructose-2,6-diphosphatase
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heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
PFKFB-3
isoform, bifunctional enzyme possessing 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase activities
PFKFB-4
isoform, bifunctional enzyme
phosphatase, fructose 2,6-di-
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6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase

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6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase

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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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bifunctional enzyme
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4

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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4
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F2KP

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FBPase

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FBPase-2

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fructose-2,6-bisphosphatase

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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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fructose-2,6-bisphosphatase
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heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

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heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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Pfk-2

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PFK-2/FBPase-2

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PFK-2/FDPase-2

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PFK2

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PFK2
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bifunctional enzyme
PFKFB

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PFKFB1

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PFKFB2

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PFKFB3

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PFKFB4

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additional information

bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
additional information
-
bifunctional enzyme, cf. EC 2.7.1.105
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate

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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
mechanism
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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94925, 94932, 94933, 94934, 94935, 94939, 94940, 94941, 94942, 94944, 94945, 94948, 94952
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
Pigeon
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
mechanism, kinetic model
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
mechanism, regulation
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
catalytic phosphorylation of His residues is essential, overview
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
catalytic site structure and interactions involving residues H258, E327, H392, R397, and H446, detailed molecular mechanism and regulation in wild-type and mutant enzymes, overview, catalytic phosphorylation of His residues is essential, overview
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
-
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
substrate binding loop structure and regulation mechanism, interactions of enzyme and substrate involve residues K47, R74, R75, R98, and T126, overview
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
beta-D-fructose 2,6-bisphosphate induces a global conformational change in the absence of AMP
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
in-line phosphoryl transfer initiated by a substrate-assisted mechanism
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beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
the complex of E. coli FBPase with beta-D-fructose 2,6-bisphosphate remains in the R-state with dynamic loops in the engaged conformation
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
fructose 2,6-bisphosphate + H2O
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
additional information
?
-
beta-D-fructose 2,6-bisphosphate + H2O

D-fructose 6-phosphate + phosphate
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
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-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB4
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
regulation mechanism, overview
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level
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-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
substrate binding loop structure, overview
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
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-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
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-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB4
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
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?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
D-fructose 2,6-bisphosphate + H2O

D-fructose 6-phosphate + phosphate
-
-
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
?
fructose 2,6-bisphosphate + H2O

?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
Pigeon
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-
-
-
?
fructose 2,6-bisphosphate + H2O
?
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94925, 94932, 94933, 94934, 94935, 94939, 94940, 94941, 94942, 94944, 94945, 94948, 94952 -
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
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?
fructose 2,6-bisphosphate + H2O
?
-
-
-
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?
fructose 2,6-bisphosphate + H2O
?
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O

fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
Pigeon
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
fructose 2-phosphate + phosphate
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
fructose 2,6-bisphosphate + H2O
fructose 6-phosphate + phosphate
-
-
-
?
additional information

?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
inducible isozyme PFKFB3 plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways, overview
-
-
?
additional information
?
-
-
inducible isozyme PFKFB3 plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways, overview
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme is important in degradation of the biological factor beta-D-fructose 2,6-bisphosphate, the bifunctional PFK-2/FDPase-2 shows a metabolic switch to change between the two separate activities, metabolic regulation overview
-
-
?
additional information
?
-
-
catalytic cycle of the catalytic domain of fructose-2 6-biphosphatase, overview, the bifunctional PFK-2/FDPase-2 shows a metabolic switch to change between the two activities, involved in glycolysis and gluconeogenesis, regulation overview
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
enzyme expression is highly reduced in diabetic mice, insulin is required for enzyme induction/regulation, a high enzyme expression level reduces blood glucose level and increases the expression of glucokinase, metabolic regulation overview
-
-
?
additional information
?
-
-
metabolic regulation, overview
-
-
?
additional information
?
-
-
PFKFB3 overexpression increases the glycolysis level
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
enzyme involved in regulation of glycolytic flux, role of glycolysis in cell cycle progression
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme is important in degradation of the biolocical factor beta-D-fructose 2,6-bisphosphate, the bifunctional PFK-2/FDPase-2 shows a metabolic switch to change between the two separate activities, involved in glycolysis and gluconeogenesis, metabolic regulation overview
-
-
?
additional information
?
-
-
catalytic cycle of the catalytic domain of fructose-2 6-biphosphatase, overview
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
-
?
additional information
?
-
-
activation of glucokinase is endogenously mediated by interaction with the bisphosphatase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase which increases the phosphorylating capacity of glucokinase
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
additional information
?
-
beta-D-fructose 2,6-bisphosphate + H2O

D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB4
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
regulation mechanism, overview
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB3
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB1
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB2
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
metabolic regulation of isozyme PFKFB4
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
beta-D-fructose 2,6-bisphosphate synthesis is catalyzed by the second enzyme activity 6-phosphofructo-2-kinase, EC 2.7.1.105
-
-
?
beta-D-fructose 2,6-bisphosphate + H2O
D-fructose 6-phosphate + phosphate
-
-
-
-
?
fructose 2,6-bisphosphate + H2O

?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
Pigeon
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
94925, 94932, 94933, 94934, 94935, 94939, 94940, 94941, 94942, 94944, 94945, 94948, 94952 -
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
fructose 2,6-bisphosphate + H2O
?
-
-
-
-
?
additional information

?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
inducible isozyme PFKFB3 plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways, overview
-
-
?
additional information
?
-
-
inducible isozyme PFKFB3 plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways, overview
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme is important in degradation of the biological factor beta-D-fructose 2,6-bisphosphate, the bifunctional PFK-2/FDPase-2 shows a metabolic switch to change between the two separate activities, metabolic regulation overview
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
enzyme expression is highly reduced in diabetic mice, insulin is required for enzyme induction/regulation, a high enzyme expression level reduces blood glucose level and increases the expression of glucokinase, metabolic regulation overview
-
-
?
additional information
?
-
-
metabolic regulation, overview
-
-
?
additional information
?
-
-
PFKFB3 overexpression increases the glycolysis level
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
enzyme involved in regulation of glycolytic flux, role of glycolysis in cell cycle progression
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
study of bifunctional enzyme evolution
-
-
?
additional information
?
-
-
the enzyme is important in degradation of the biolocical factor beta-D-fructose 2,6-bisphosphate, the bifunctional PFK-2/FDPase-2 shows a metabolic switch to change between the two separate activities, involved in glycolysis and gluconeogenesis, metabolic regulation overview
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
-
?
additional information
?
-
-
the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting
-
-
?
additional information
?
-
-
study of bifunctional enzyme evolution
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E)-2-(1,3-benzodioxol-5-ylmethylidene)butanedioic acid
-
mimics binding pattern of fructose 6-phosphate
([2-[(5-nitropyridin-2-yl)amino]phenyl]sulfanyl)acetic acid
-
mimics binding pattern of fructose 6-phosphate
1,1'-ethane-1,2-diylbis(4-acetylpyrrolidine-2,3,5-trione)
-
mimics binding pattern of fructose 6-phosphate
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2-methyl-4-nitro-1H-imidazol-1-yl)ethanol
-
mimics binding pattern of fructose 6-phosphate
1-(3-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
-
1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
-
1-amino-4-(2-nitro-1H-imidazol-1-yl)butan-2-ol
-
mimics binding pattern of fructose 6-phosphate
2,5-anhydro-D-mannitol 6-phosphate
-
-
2-((5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)amino)acetamide
-
-
2-(1,3-benzodioxol-5-ylmethyl)-3-methylbutanedioic acid
-
mimics binding pattern of fructose 6-phosphate
2-(2-nitrophenoxy)-N-phenylacetamide
-
mimics binding pattern of fructose 6-phosphate
2-(3H-indol-7-ylmethyl)butanedioic acid
-
mimics binding pattern of fructose 6-phosphate
2-(5-amino-4-carbamoyl-1H-pyrazol-1-yl)ethanesulfonic acid
-
mimics binding pattern of fructose 6-phosphate
2-(5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)-1,2,3,4-tetrahydroisoquinoline-5-carbonitrile
-
-
2-(acetylamino)-beta-oxophenylalanine
-
mimics binding pattern of fructose 6-phosphate
2-nitro-N-(pyrazin-2-ylmethyl)benzenesulfonamide
-
mimics binding pattern of fructose 6-phosphate
2-nitro-N-quinolin-3-ylbenzenesulfonamide
-
mimics binding pattern of fructose 6-phosphate
2-[(4-nitro-1H-benzimidazol-7-yl)sulfanyl]ethyl benzoate
-
mimics binding pattern of fructose 6-phosphate
2-[(5-nitropyridin-2-yl)amino]ethyl 5-nitro-1H-pyrrole-2-carboxylate
-
mimics binding pattern of fructose 6-phosphate
2-[(furan-2-ylmethyl)amino]-5-nitrobenzoic acid
-
mimics binding pattern of fructose 6-phosphate
2-[[(2Z)-2-(phenylhydrazono)acetyl]amino]benzoic acid
-
mimics binding pattern of fructose 6-phosphate
2-[[2-(2,4-dinitrophenyl)hydrazino]carbonyl]benzoic acid
-
mimics binding pattern of fructose 6-phosphate
3,3'-(2,4,6-trioxo-1,3,5-triazinane-1,3-diyl)dipropanoic acid
-
mimics binding pattern of fructose 6-phosphate
3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)-N-(tetrahydrofuran-2-ylmethyl)propanamide
-
mimics binding pattern of fructose 6-phosphate
3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
-
-
3-acetylphenyl (3-acetylphenyl)acetate
-
mimics binding pattern of fructose 6-phosphate
3-[(2-pyridin-2-ylhydrazino)carbonyl]pyrazine-2-carboxylic acid
-
mimics binding pattern of fructose 6-phosphate
4-(4-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-5-bromo-6-oxopyridazin-1(6H)-yl)benzonitrile
-
-
4-bromo-2-phenyl-5-(((tetrahydrofuran-2-yl)methyl)amino)pyridazin-3(2H)-one
-
-
4-bromo-2-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridazin-3(2H)-one
-
-
4-bromo-5-morpholino-2-phenylpyridazin-3(2H)-one
-
-
5,6,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
-
competitive inhibitor
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzyl-4-bromopyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(3-phenylpropyl)pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-((2-(dimethylamino)ethyl)-amino)benzyl)pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-(trifluoromethoxy)phenyl)-pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-chlorophenyl)pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-iodobenzyl)pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(pyrimidin-5-yl)pyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenethylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-chloro-2-phenylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-ethoxy-2-phenylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-iodo-2-phenylpyridazin-3(2H)-one
-
-
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-isopropyl-2-phenylpyridazin-3(2H)-one
-
-
5-hydroxy-N-(4-nitro-1,3-thiazol-2-yl)-2,4-dioxopentanamide
-
mimics binding pattern of fructose 6-phosphate
citrate
-
inhibits the cardiac enzyme
Cyclic AMP dependent protein kinase
-
causes inactivation
-
D-fructose-1,6-bisphosphate
-
D-glucose-1,6-bisphosphate
-
D-psicose 6-phosphate
-
poor inhibitor
D-ribose 5-phosphate
-
poor inhibitor
D-tagatose 6-phosphate
-
poor inhibitor
diethyldicarbonate
-
inactivation
dimethyloxalylglycine
inhibits the splice isozyme PFKFB-4
ethyl 1-(6-oxo-1-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1,6-dihydropyridazin-4-yl)-1H-1,2,3-triazole-4-carboxylate
-
-
F-
-
in presence of glycerol 3-or 2-phosphate
Insulin
-
opposes action of glucagon or epinephrine
-
L-Sorbose 6-phosphate
-
-
N-bromoacetylethanolamine
AMP

-
beta-D-fructose 2,6-bisphosphate has no effect on AMP inhibition
AMP
-
beta-D-fructose 2,6-bisphosphate enhances AMP inhibition
D-fructose 6-phosphate

-
-
D-fructose 6-phosphate
mixed type
fructose 6-phosphate

-
noncompetetive
fructose 6-phosphate
-
noncompetetive
fructose 6-phosphate
Pigeon
-
-
fructose 6-phosphate
-
noncompetetive
glycerol 1-phosphate

-
inhibition at low substrate concentrations
glycerol 1-phosphate
-
inhibits at subsaturating substrate concentrations
N-bromoacetylethanolamine

-
-
N-bromoacetylethanolamine
-
-
phosphate

-
phosphate
-
inhibition at low substrate concentrations
phosphate
-
inhibits at subsaturating substrate concentrations
vanadate

-
50% inhibition at 0.15 mM
additional information

not inhibitory: diphosphate
-
additional information
-
not inhibitory: diphosphate
-
additional information
-
expression of isozyme PFKFB3 is reduced by treatment of 3T3-L1 cells with insulin
-
additional information
-
inhibitor screening and structure-based docking, overview
-
additional information
-
expression of isozyme PFKFB3 is reduced by prolonged treatment of 3T3-L1 cells with insulin
-
additional information
-
streptozotocin highly reduces enzyme expression, treated mice show undetecable low levels of insulin, the effect is reversible by application of insulin
-
additional information
a significant decrease of isoform PFKFB-4 mRNA expression is found in the lung from rats treated by methyl tretbutyl ether during two months; a significant decrease of isoform PFKFB-4 mRNA expression is found in the lung from rats treated by methyl tretbutyl ether during two months
-
additional information
a significant decrease of isoform PFKFB-4 mRNA expression is found in the lung from rats treated by methyl tretbutyl ether during two months; a significant decrease of isoform PFKFB-4 mRNA expression is found in the lung from rats treated by methyl tretbutyl ether during two months
-
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1
2-((5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)amino)acetamide
Homo sapiens
-
IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.5
2-(5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)-1,2,3,4-tetrahydroisoquinoline-5-carbonitrile
Homo sapiens
-
IC50 above 0.5 mM,in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.026
3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.0084
4-(4-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-5-bromo-6-oxopyridazin-1(6H)-yl)benzonitrile
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
1
4-bromo-2-phenyl-5-(((tetrahydrofuran-2-yl)methyl)amino)pyridazin-3(2H)-one
Homo sapiens
-
IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
1
4-bromo-2-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridazin-3(2H)-one
Homo sapiens
-
IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
1
4-bromo-5-morpholino-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
IC50 above 1.0 mM,in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.0034
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzyl-4-bromopyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
10
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzylpyridazin-3(2H)-one
Homo sapiens
-
IC50 above 10 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.011
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(3-phenylpropyl)pyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.5
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-((2-(dimethylamino)ethyl)-amino)benzyl)pyridazin-3(2H)-one
Homo sapiens
-
IC50 above 0.5 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.0091
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-(trifluoromethoxy)phenyl)-pyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.007
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-chlorophenyl)pyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.0087
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-iodobenzyl)pyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.0096
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(pyrimidin-5-yl)pyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.0026
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenethylpyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.0074
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.0262
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-chloro-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
1
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-ethoxy-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
IC50 above 1.0 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.013
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-iodo-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.5
5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-isopropyl-2-phenylpyridazin-3(2H)-one
Homo sapiens
-
IC50 above 0.5 mM, in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
0.055
ethyl 1-(6-oxo-1-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1,6-dihydropyridazin-4-yl)-1H-1,2,3-triazole-4-carboxylate
Homo sapiens
-
in 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/ml bovine serum albumin, at 30ưC
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