Literature summary for 3.1.3.46 extracted from

Zhu, Z.; Ling, S.; Yang, Q.H.; Li, L.
The difference in the carboxy-terminal sequence is responsible for the difference in the activity of chicken and rat liver fructose-2,6-bisphosphatase (2000), Biol. Chem., 381, 1195-1202.

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Protein Variants

Protein Variants	Comment	Organism
additional information	chimeric enzymes of chicken catalytic core or intact enzyme plus rat C-terminal 25 amino acids show kinetic properties of rat enzyme	Gallus gallus
P456E/P457A/A458E	change of chicken sequence to rat sequence, enzyme behaves like rat enzyme	Gallus gallus

Inhibitors

Inhibitors	Comment	Organism	Structure
D-fructose 6-phosphate	-	Gallus gallus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00013	-	D-fructose 2,6-bisphosphate	pH 7.4	Gallus gallus

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-fructose 2,6-bisphosphate + H2O	-	Gallus gallus	D-fructose 6-phosphate + phosphate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
9.7	-	D-fructose 6-phosphate	pH 7.4	Gallus gallus

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Release 2023.1 (January 2023)