Application | Comment | Organism |
---|---|---|
molecular biology | overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion | Mus musculus |
molecular biology | overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression in hepatocytes by incubation for 2h with increasing titres of adenoviral vectors | Rattus norvegicus |
expression in MIN-6 cell by incubation for 2h with increasing titres of adenoviral vectors | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting | ? | - |
? | |
additional information | Rattus norvegicus | the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting | ? | - |
? | |
additional information | Mus musculus C57/BL6 | the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting | ? | - |
? | |
additional information | Rattus norvegicus Wistar | the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
C57/BL6 | - |
Mus musculus C57/BL6 | - |
C57/BL6 | - |
Rattus norvegicus | - |
Wistar | - |
Rattus norvegicus Wistar | - |
Wistar | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
INS-1 cell | - |
Rattus norvegicus | - |
MIN-6 cell | - |
Mus musculus | - |
additional information | PFKFB2 and PFKFB3 mRNA is expressed in human islet cells | Homo sapiens | - |
pancreatic islet | - |
Mus musculus | - |
pancreatic islet | - |
Homo sapiens | - |
pancreatic islet | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-D-fructose 2,6-bisphosphate + H2O | - |
Mus musculus | D-fructose 6-phosphate + phosphate | - |
? | |
beta-D-fructose 2,6-bisphosphate + H2O | - |
Homo sapiens | D-fructose 6-phosphate + phosphate | - |
? | |
beta-D-fructose 2,6-bisphosphate + H2O | - |
Rattus norvegicus | D-fructose 6-phosphate + phosphate | - |
? | |
beta-D-fructose 2,6-bisphosphate + H2O | - |
Mus musculus C57/BL6 | D-fructose 6-phosphate + phosphate | - |
? | |
beta-D-fructose 2,6-bisphosphate + H2O | - |
Rattus norvegicus Wistar | D-fructose 6-phosphate + phosphate | - |
? | |
additional information | the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting | Mus musculus | ? | - |
? | |
additional information | the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting | Rattus norvegicus | ? | - |
? | |
additional information | the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting | Mus musculus C57/BL6 | ? | - |
? | |
additional information | the enzyme rather than its substrate fructose 2,6-bisphosphate is crucial in glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting | Rattus norvegicus Wistar | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase | - |
Mus musculus |
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase | - |
Homo sapiens |
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase | - |
Rattus norvegicus |
FBPase-2 | - |
Mus musculus |
FBPase-2 | - |
Homo sapiens |
FBPase-2 | - |
Rattus norvegicus |
PFKFB1 | - |
Mus musculus |
PFKFB1 | - |
Homo sapiens |
PFKFB1 | - |
Rattus norvegicus |
PFKFB2 | - |
Mus musculus |
PFKFB2 | - |
Homo sapiens |
PFKFB2 | - |
Rattus norvegicus |
PFKFB3 | - |
Mus musculus |
PFKFB3 | - |
Homo sapiens |
PFKFB3 | - |
Rattus norvegicus |