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Literature summary for 3.1.3.46 extracted from

  • Minchenko, O.H.; Ogura, T.; Opentanova, I.L.; Minchenko, D.O.; Esumi, H.
    Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation (2005), Mol. Cell. Biochem., 280, 227-234.
    View publication on PubMed
Search for more literature for 3.1.3.46

Cloned(Commentary)

Cloned (Comment) Organism
gene PFKFB4, DNA and amino acid sequence determination, expression analysis in DB-1 melanoma cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dimethyloxalylglycine inhibits the splice isozyme PFKFB-4 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-D-fructose 2,6-bisphosphate + H2O Homo sapiens the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition D-fructose 6-phosphate + phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16877 PFKFB4 gene, promoter region, and 5' untranslated region, partial sequence; minor splice isozyme PFKFB-4, major isozyme PFKFB-3
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Source Tissue

Source Tissue Comment Organism Textmining
DB-1 cell melanoma cell line, minor splice isozyme PFKFB-4, major isozyme is PFKFB-3, isozyme PFKFB-4 is overexpressed in hypoxic conditions Homo sapiens
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melanoma cell minor splice isozyme PFKFB-4, major isozyme is PFKFB-3 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-fructose 2,6-bisphosphate + H2O the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition Homo sapiens D-fructose 6-phosphate + phosphate
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 ?

Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
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 Homo sapiens
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4
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 Homo sapiens
More bifunctional enzyme, cf. EC 2.7.1.105 Homo sapiens
PFKFB
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 Homo sapiens