Cloned (Comment) | Organism |
---|---|
overexpression of PFK-2/FBPase-2 in MIN6 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of PFK-2/FBPase-2 in MIN6 cells results in increased insulin secretion | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Rattus norvegicus |
PFK-2/FBPase-2 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | analysis of glucokinase/6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase complex formation, binding and activation of GK by PFK-2/FBPase-2 in beta-cells is promoted by glucose, resulting in an enhancement of insulin secretion at stimulatory glucose concentrations, without affecting basal insulin secretion | Rattus norvegicus |
physiological function | the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase acts as an endogenous glucokinase activator | Rattus norvegicus |