Literature summary for 3.1.3.46 extracted from

Kessler, R.; Bleichert, F.; Warnke, J.P.; Eschrich, K.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas (2008), J. Neurooncol., 86, 257-264.

Search for more literature for 3.1.3.46

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	astrocytoma cell, glioblastoma cell and non neoplastic brain tissue	Homo sapiens	-
additional information	PFKFB3 protein level but not mRNA expression is up-regulated in high-grade astrocytomas	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
beta-D-fructose 2,6-bisphosphate + H2O	-	Homo sapiens	D-fructose 6-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase	-	Homo sapiens
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (gene PFKFB3)	bifunctional enzyme	Homo sapiens
PFK-2/FBPase-2	-	Homo sapiens
PFKFB3	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the protein levels are markedly elevated in high-grade astrocytomas relative to low-grade astrocytomas and corresponding non-neoplastic brain tissue, whereas no significant increase of PFKFB3 mRNA is observed in high-grade astrocytomas	additional information

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)