EC Number   |
Application |
Reference |
|---|
   3.1.3.46 | agriculture |
FK2P in rice is encoded by two genes OsF2KP1 and OsF2KP2, both are involved in the regulation of primary carbon metabolism in rice leaves during the light period |
681609 |
| 3.1.3.46 | medicine |
enzyme regulation by hormones, overview |
650931 |
| 3.1.3.46 | medicine |
in colonic and bladder cancer cells, additive growth inhibitory effects are seen with phenformin and with an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3. The increased acidification of the culture medium and glucose uptake caused by phenformin is blocked by combined treatment with PFKFB3 inhibitors |
749587 |
| 3.1.3.46 | medicine |
overexpression of enzyme results in increase of glucokinase activity, interaction of enzyme with glucokinase at concentrations of glucose physiologically relevant for glucokinase activation, possible site for intervention in type 2 diabetes treatment |
650947 |
| 3.1.3.46 | medicine |
PFKFB3 is constitutively expressed in human leukemias and solid tumor cells, inhibitors could act as antineoplastic agents |
673215 |
| 3.1.3.46 | medicine |
pharmacological disruption of the PFKFB4 kinase domain may have clinical utility for the treatment of human cancers |
730530 |
| 3.1.3.46 | medicine |
the enzyme is a target for cancer chemotherapy |
713747 |
| 3.1.3.46 | medicine |
tumor suppressor p53 regulates the expression of PFKFB4 and p53-deficient cancer cells are highly dependent on the function of the enzyme. Depletion of PFKFB4 from p53-deficient cancer cells increases levels of the allosteric regulator fructose-2,6-bisphosphate, leading to increased glycolytic activity but decreased routing of metabolites through the oxidative arm of the pentose-phosphate pathway. PFKFB4 is also required to support the synthesis and regeneration of nicotinamide adenine dinucleotide phosphate (NADPH) in p53-deficient cancer cells. Depletion of PFKFB4-attenuated cellular biosynthetic activity and results in the accumulation of reactive oxygen species and cell death in the absence of p53. Silencing of PFKFB4-induces apoptosis in p53-deficient cancer cells in vivo and interferes with tumor growth |
751761 |
| 3.1.3.46 | molecular biology |
overexpression alone has negligible effects on insulin secretion, only in combination with 6-phosphofructo-2-kinase, partial down-regulation of endogenous PFKFB2 and PFKFB3 in INS1 cells by siRNA decreased PFK-2/FBPase-2 protein, fructose 2,6-bisphosphate content, glucokinase activity and glucose-induced insulin secretion |
-, 678087 |
| 3.1.3.46 | pharmacology |
a pharmacophore map is generated and validated to identify inhibitors of the F6PFBPase complex |
681500 |
