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Literature summary for 3.1.3.46 extracted from
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis (2004), Biochem. J., 381, 561-579.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| genes PFKFB1-4, chromosomal localization of tissue-specific isozymes, phylogenetic analysis, overview, transcriptional control of isozymes, overview | Homo sapiens |
| genes PFKFB1-4, chromosomal localization of tissue-specific isozymes, phylogenetic analysis, overview, transcriptional control of isozymes, overview | Rattus norvegicus |
| phylogenetic analysis | Schizosaccharomyces pombe |
| phylogenetic analysis | Leishmania major |
| phylogenetic analysis | Arabidopsis thaliana |
| phylogenetic analysis | Drosophila melanogaster |
| phylogenetic analysis, transcriptional control of isozymes, overview | Bos taurus |
| phylogenetic analysis, transcriptional control of isozymes, overview | Mus musculus |
| possible evolution of the proteobacterial gene by horizontal gene transfer from an eukaryote, phylogenetic analysis | Desulfovibrio desulfuricans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-D-fructose 2,6-bisphosphate + H2O | Schizosaccharomyces pombe | - |
D-fructose 6-phosphate + phosphate | - |
? |  |
| beta-D-fructose 2,6-bisphosphate + H2O | Desulfovibrio desulfuricans | - |
D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Leishmania major | - |
D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Arabidopsis thaliana | - |
D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Drosophila melanogaster | - |
D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Homo sapiens | metabolic regulation of isozyme PFKFB1 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Bos taurus | metabolic regulation of isozyme PFKFB1 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Rattus norvegicus | metabolic regulation of isozyme PFKFB1 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Homo sapiens | metabolic regulation of isozyme PFKFB2 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Rattus norvegicus | metabolic regulation of isozyme PFKFB2 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Mus musculus | metabolic regulation of isozyme PFKFB2 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Bos taurus | metabolic regulation of isozyme PFKFB2 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Homo sapiens | metabolic regulation of isozyme PFKFB3 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Bos taurus | metabolic regulation of isozyme PFKFB3 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Mus musculus | metabolic regulation of isozyme PFKFB3 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Homo sapiens | metabolic regulation of isozyme PFKFB4 | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | Rattus norvegicus | metabolic regulation of isozyme PFKFB4 | D-fructose 6-phosphate + phosphate | - |
? | |
| additional information | Schizosaccharomyces pombe | study of bifunctional enzyme evolution | ? | - |
? | |
| additional information | Desulfovibrio desulfuricans | study of bifunctional enzyme evolution | ? | - |
? | |
| additional information | Leishmania major | study of bifunctional enzyme evolution | ? | - |
? | |
| additional information | Arabidopsis thaliana | study of bifunctional enzyme evolution | ? | - |
? | |
| additional information | Homo sapiens | study of bifunctional enzyme evolution | ? | - |
? | |
| additional information | Rattus norvegicus | study of bifunctional enzyme evolution | ? | - |
? | |
| additional information | Bos taurus | study of bifunctional enzyme evolution | ? | - |
? | |
| additional information | Mus musculus | study of bifunctional enzyme evolution | ? | - |
? | |
| additional information | Drosophila melanogaster | study of bifunctional enzyme evolution | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | Q9MB58 | - |
- |
| Bos taurus | P26285 | heart isozyme PFKFB2; genes PFKFB1-4, four isozymes | - |
| Bos taurus | P49872 | liver isozyme PFKFB1; genes PFKFB1-4, four isozymes | - |
| Bos taurus | Q28901 | brain isozyme PFKFB3; genes PFKFB1-4, four isozymes | - |
| Desulfovibrio desulfuricans | - |
- |
- |
| Drosophila melanogaster | Q9VWH7 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase long form; gene Pfrx | - |
| Homo sapiens | O60825 | heart isozyme PFKFB2; genes PFKFB1-4, four isozymes | - |
| Homo sapiens | P16118 | liver isozyme PFKFB1; genes PFKFB1-4, four isozymes | - |
| Homo sapiens | Q16875 | brain/placenta isozyme PFKFB3; genes PFKFB1-4, four isozymes | - |
| Homo sapiens | Q16877 | testis isozyme PFKFB4; genes PFKFB1-4, four isozymes | - |
| Leishmania major | - |
This UniProt-ID has been deleted | - |
| Mus musculus | P70265 | heart isozyme PFKFB2; genes PFKFB1-4, four isozymes | - |
| Mus musculus | Q9ESY2 | inducible isozyme PFKFB3; genes PFKFB1-4, four isozymes | - |
| Rattus norvegicus | O35552 | brain isozyme PFKFB2; genes PFKFB1-4, four isozymes | - |
| Rattus norvegicus | P07953 | liver isozyme PFKFB1; genes PFKFB1-4, four isozymes | - |
| Rattus norvegicus | P25114 | testis isozyme PFKFB4; genes PFKFB1-4, four isozymes | - |
| Rattus norvegicus | Q9JJH5 | heart isozyme PFKFB2; genes PFKFB1-4, four isozymes | - |
| Schizosaccharomyces pombe | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview | Schizosaccharomyces pombe | |
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview | Desulfovibrio desulfuricans | |
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview | Leishmania major | |
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview | Arabidopsis thaliana | |
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview | Homo sapiens | |
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview | Rattus norvegicus | |
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview | Bos taurus | |
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview | Mus musculus | |
| beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview | Drosophila melanogaster |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | isozyme PFKFB3 | Homo sapiens | - |
| brain | isozyme PFKFB3 | Bos taurus | - |
| brain | specific isozyme PFKFB2 | Rattus norvegicus | - |
| heart | isozyme PFKFB2 | Homo sapiens | - |
| heart | isozyme PFKFB2 | Mus musculus | - |
| heart | isozyme PFKFB2 | Bos taurus | - |
| heart | specific isozyme PFKFB2 | Rattus norvegicus | - |
| liver | isozyme PFKFB1 | Homo sapiens | - |
| liver | isozyme PFKFB1 | Bos taurus | - |
| liver | specific isozyme PFKFB1 | Rattus norvegicus | - |
| additional information | tissue-specific expression of the different isozymes, overview | Homo sapiens | - |
| additional information | tissue-specific expression of the different isozymes, overview | Rattus norvegicus | - |
| additional information | tissue-specific expression of the different isozymes, overview | Bos taurus | - |
| additional information | tissue-specific expression of the different isozymes, overview | Mus musculus | - |
| placenta | inducible isozyme PFKFB3 | Mus musculus | - |
| placenta | isozyme PFKFB3 | Homo sapiens | - |
| placenta | isozyme PFKFB3 | Bos taurus | - |
| placenta | specific isozyme PFKFB2 | Rattus norvegicus | - |
| testis | specific isozyme PFKFB4 | Homo sapiens | - |
| testis | specific isozyme PFKFB4 | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Schizosaccharomyces pombe | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Desulfovibrio desulfuricans | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Leishmania major | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Arabidopsis thaliana | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Homo sapiens | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Rattus norvegicus | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Bos taurus | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Mus musculus | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Drosophila melanogaster | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB1 | Homo sapiens | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB1 | Bos taurus | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB1 | Rattus norvegicus | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB2 | Homo sapiens | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB2 | Rattus norvegicus | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB2 | Mus musculus | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB2 | Bos taurus | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB3 | Homo sapiens | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB3 | Bos taurus | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB3 | Mus musculus | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB4 | Homo sapiens | D-fructose 6-phosphate + phosphate | - |
? | |
| beta-D-fructose 2,6-bisphosphate + H2O | metabolic regulation of isozyme PFKFB4 | Rattus norvegicus | D-fructose 6-phosphate + phosphate | - |
? | |
| additional information | study of bifunctional enzyme evolution | Schizosaccharomyces pombe | ? | - |
? | |
| additional information | study of bifunctional enzyme evolution | Desulfovibrio desulfuricans | ? | - |
? | |
| additional information | study of bifunctional enzyme evolution | Leishmania major | ? | - |
? | |
| additional information | study of bifunctional enzyme evolution | Arabidopsis thaliana | ? | - |
? | |
| additional information | study of bifunctional enzyme evolution | Homo sapiens | ? | - |
? | |
| additional information | study of bifunctional enzyme evolution | Rattus norvegicus | ? | - |
? | |
| additional information | study of bifunctional enzyme evolution | Bos taurus | ? | - |
? | |
| additional information | study of bifunctional enzyme evolution | Mus musculus | ? | - |
? | |
| additional information | study of bifunctional enzyme evolution | Drosophila melanogaster | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | homodimeric bifunctional enzyme | Schizosaccharomyces pombe |
| dimer | homodimeric bifunctional enzyme | Desulfovibrio desulfuricans |
| dimer | homodimeric bifunctional enzyme | Leishmania major |
| dimer | homodimeric bifunctional enzyme | Arabidopsis thaliana |
| dimer | homodimeric bifunctional enzyme | Homo sapiens |
| dimer | homodimeric bifunctional enzyme | Rattus norvegicus |
| dimer | homodimeric bifunctional enzyme | Bos taurus |
| dimer | homodimeric bifunctional enzyme | Mus musculus |
| dimer | homodimeric bifunctional enzyme | Drosophila melanogaster |
| More | domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview | Schizosaccharomyces pombe |
| More | domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview | Leishmania major |
| More | domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview | Arabidopsis thaliana |
| More | domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview | Homo sapiens |
| More | domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview | Rattus norvegicus |
| More | domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview | Bos taurus |
| More | domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview | Drosophila melanogaster |
| More | head-to-head structure of the two subunits of the bifunctional enzyme, overview | Desulfovibrio desulfuricans |
| More | head-to-head structure of the two subunits of the bifunctional enzyme, overview | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Schizosaccharomyces pombe |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Desulfovibrio desulfuricans |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Leishmania major |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Arabidopsis thaliana |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Homo sapiens |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Rattus norvegicus |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Bos taurus |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Mus musculus |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Drosophila melanogaster |
| F2KP | - |
Arabidopsis thaliana |
| FBPase-2 | - |
Schizosaccharomyces pombe |
| FBPase-2 | - |
Desulfovibrio desulfuricans |
| FBPase-2 | - |
Leishmania major |
| FBPase-2 | - |
Arabidopsis thaliana |
| FBPase-2 | - |
Homo sapiens |
| FBPase-2 | - |
Rattus norvegicus |
| FBPase-2 | - |
Bos taurus |
| FBPase-2 | - |
Mus musculus |
| FBPase-2 | - |
Drosophila melanogaster |
| fructose-2,6-bisphosphatase | - |
Schizosaccharomyces pombe |
| fructose-2,6-bisphosphatase | - |
Desulfovibrio desulfuricans |
| fructose-2,6-bisphosphatase | - |
Leishmania major |
| fructose-2,6-bisphosphatase | - |
Arabidopsis thaliana |
| fructose-2,6-bisphosphatase | - |
Homo sapiens |
| fructose-2,6-bisphosphatase | - |
Rattus norvegicus |
| fructose-2,6-bisphosphatase | - |
Bos taurus |
| fructose-2,6-bisphosphatase | - |
Mus musculus |
| fructose-2,6-bisphosphatase | - |
Drosophila melanogaster |
| Lm1 | - |
Leishmania major |
| More | bifunctional enzyme, cf. EC 2.7.1.105 | Schizosaccharomyces pombe |
| More | bifunctional enzyme, cf. EC 2.7.1.105 | Desulfovibrio desulfuricans |
| More | bifunctional enzyme, cf. EC 2.7.1.105 | Leishmania major |
| More | bifunctional enzyme, cf. EC 2.7.1.105 | Arabidopsis thaliana |
| More | bifunctional enzyme, cf. EC 2.7.1.105 | Homo sapiens |
| More | bifunctional enzyme, cf. EC 2.7.1.105 | Rattus norvegicus |
| More | bifunctional enzyme, cf. EC 2.7.1.105 | Bos taurus |
| More | bifunctional enzyme, cf. EC 2.7.1.105 | Mus musculus |
| More | bifunctional enzyme, cf. EC 2.7.1.105 | Drosophila melanogaster |
| PFK-2/FBPase-2 | - |
Schizosaccharomyces pombe |
| PFK-2/FBPase-2 | - |
Desulfovibrio desulfuricans |
| PFK-2/FBPase-2 | - |
Leishmania major |
| PFK-2/FBPase-2 | - |
Arabidopsis thaliana |
| PFK-2/FBPase-2 | - |
Homo sapiens |
| PFK-2/FBPase-2 | - |
Rattus norvegicus |
| PFK-2/FBPase-2 | - |
Bos taurus |
| PFK-2/FBPase-2 | - |
Mus musculus |
| PFK-2/FBPase-2 | - |
Drosophila melanogaster |
| Pfk26 | - |
Schizosaccharomyces pombe |
| Pfk27 | - |
Schizosaccharomyces pombe |
| RH2K | - |
Rattus norvegicus |
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