Literature summary for 3.1.3.46 extracted from

Kretschmer, M.; Schellenberger, W.; Otto, A.; Kessler, R.; Hofmann, E.
Fructose-2,6-bisphosphatase and 6-phosphofructo-2-kinase are separable in yeast (1987), Biochem. J., 246, 755-759.

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Activating Compound

Activating Compound	Comment	Organism	Structure
glycerol 1-phosphate	counteracts fructose 6-phosphate inhibition	Saccharomyces cerevisiae
Protein phosphatase 2A	cyclic AMP dependent protein kinase inactivation reversible by	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
Cyclic AMP dependent protein kinase	causes inactivation	Saccharomyces cerevisiae
fructose 6-phosphate	-	Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0001	-	fructose 2,6-bisphosphate	-	Saccharomyces cerevisiae
0.0003	-	fructose 2,6-bisphosphate	-	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
fructose 2,6-bisphosphate + H2O	Saccharomyces cerevisiae	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Saccharomyces cerevisiae

Reaction

Reaction	Comment	Organism	Reaction ID
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate	bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase	Saccharomyces cerevisiae	a

Storage Stability

Storage Stability	Organism
-20°C, 20% glycerol	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fructose 2,6-bisphosphate + H2O	-	Saccharomyces cerevisiae	fructose 6-phosphate + phosphate	-	?
fructose 2,6-bisphosphate + H2O	-	Saccharomyces cerevisiae	?	-	?

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Release 2023.1 (January 2023)