Literature summary for 3.4.24.B28 extracted from

Ungerer, C.; Doberstein, K.; Buerger, C.; Hardt, K.; Boehncke, W.H.; Boehm, B.; Pfeilschifter, J.; Dummer, R.; Mihic-Probst, D.; Gutwein, P.
ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma (2010), Biochem. Biophys. Res. Commun., 401, 363-369.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell	melanocytes and endothelial cells of benign nevi and melanoma tissue	Homo sapiens	-
MeWo cell	-	Homo sapiens	-
NW-1539 cell	-	Homo sapiens	-
SK-MEL-5 cell	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * about 100000, SDS-PAGE	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	ADAM15 expression is down-regulated in melanoma metastasis compared to primary melanoma. Interferon-gamma and tumor growth factor-beta1 down-regulate ADAM15 protein levels in melanoma cells	down

General Information

General Information	Comment	Organism
physiological function	overexpression of ADAM15 in melanoma cells reduces the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. The downregulation of ADAM15 plays an important role in melanoma progression. ADAM15 act as a tumorsuppressor in melanoma	Homo sapiens

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Release 2023.1 (January 2023)