EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
4.1.1.50 | adenosylmethionine decarboxylase |
melanoma cell |
- |
4690 |
3.4.21.68 | t-Plasminogen activator |
melanoma cell |
- |
29577, 29592 |
3.4.21.68 | t-Plasminogen activator |
melanoma cell |
cell-conditioned serum-free medium, Bowes |
29587 |
3.4.11.2 | membrane alanyl aminopeptidase |
melanoma cell |
- |
35865, 664466, 665112 |
1.8.1.9 | thioredoxin-disulfide reductase |
melanoma cell |
amelanotic |
394906 |
1.8.1.9 | thioredoxin-disulfide reductase |
melanoma cell |
metastatic melanotic |
394906, 394908, 394909, 394911 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
melanoma cell |
- |
487039 |
2.7.10.2 | non-specific protein-tyrosine kinase |
melanoma cell |
elevated levels of malignant cells |
490359 |
1.14.18.1 | tyrosinase |
melanoma cell |
- |
636339, 636340, 636355, 636360, 636374, 636398, 636401, 636402, 636412, 636416, 636417, 636418, 636422, 636425, 636430, 696686, 744671, 746188, 746346 |
2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase |
melanoma cell |
- |
637260 |
2.4.2.28 | S-methyl-5'-thioadenosine phosphorylase |
melanoma cell |
reduced activity due to hypermethylation of the promotor |
637557 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
Cloudman mouse melanoma cells |
648804 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
- |
648805, 648814, 748797 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
B16/F10 |
648807 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
Cloudman mouse melanoma cells (S91) |
648809 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
B16 |
648811, 648812 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
of neural crest origin |
648813 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
B16 melanoma |
648815 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
melan-a, melan-b, melan-c melanocytes |
648817 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
WM35 cell line |
648819 |
4.1.1.33 | diphosphomevalonate decarboxylase |
melanoma cell |
B16F10 |
650501 |
2.4.1.90 | N-acetyllactosamine synthase |
melanoma cell |
Bowes melanoma cell line |
658123 |
1.14.16.4 | tryptophan 5-monooxygenase |
melanoma cell |
- |
658187 |
2.5.1.60 | protein geranylgeranyltransferase type II |
melanoma cell |
significant overexpression of RabGGT-beta and Rab-GGT-alpha compared to normal tissue |
658377 |
1.14.15.18 | calcidiol 1-monooxygenase |
melanoma cell |
- |
659811 |
2.7.11.1 | non-specific serine/threonine protein kinase |
melanoma cell |
- |
662601 |
2.7.12.2 | mitogen-activated protein kinase kinase |
melanoma cell |
choroidal from eyes, and cutaneous |
665489 |
2.7.11.22 | cyclin-dependent kinase |
melanoma cell |
- |
665840 |
3.2.1.24 | alpha-mannosidase |
melanoma cell |
- |
665978 |
3.5.3.15 | protein-arginine deiminase |
melanoma cell |
moderate expression |
666311 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
melanoma cell |
minor splice isozyme PFKFB-4, major isozyme is PFKFB-3 |
666334 |
3.4.22.15 | cathepsin L |
melanoma cell |
cathepsin L activity was detected in the cell culture supernatant by lithium dodecyl sulfate gelatin zymography |
667194 |
3.4.24.81 | ADAM10 endopeptidase |
melanoma cell |
- |
668181 |
3.4.24.56 | insulysin |
melanoma cell |
- |
668184 |
3.4.24.B4 | matrix metalloproteinase-13 |
melanoma cell |
cutaneous malignant melanoma |
668973 |
3.4.24.7 | interstitial collagenase |
melanoma cell |
VMM5 cells, VMM12cells and VMM39. Constitutive overexpression of collagenase 1 is mediated by the ERK pathway in invasive melanoma cells |
669246 |
2.7.1.91 | sphingosine kinase |
melanoma cell |
- |
671356, 761980 |
2.4.2.28 | S-methyl-5'-thioadenosine phosphorylase |
melanoma cell |
- |
671628 |
2.4.2.28 | S-methyl-5'-thioadenosine phosphorylase |
melanoma cell |
MTAP expression analysis |
671628 |
2.7.1.107 | diacylglycerol kinase (ATP) |
melanoma cell |
- |
672420 |
2.7.1.107 | diacylglycerol kinase (ATP) |
melanoma cell |
expression of isoform diacylglycerol kinase alpha in several melanoma cell lines but not in noncancerous melanocytes |
672420 |
2.7.7.8 | polyribonucleotide nucleotidyltransferase |
melanoma cell |
- |
672972, 723628 |
6.3.2.2 | glutamate-cysteine ligase |
melanoma cell |
gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells |
676099 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
melanoma cell |
sialic acid O-acetylation levels in different samples, overview |
677235 |
4.1.1.17 | ornithine decarboxylase |
melanoma cell |
- |
677508 |
3.1.3.5 | 5'-nucleotidase |
melanoma cell |
- |
677542 |
3.4.22.1 | cathepsin B |
melanoma cell |
- |
681195, 753138 |
3.4.22.38 | cathepsin K |
melanoma cell |
immunostaining reveals strong catK expression in most primary melanomas and all cutaneous melanoma metastases. Melanocytic nevi also demonstrates catK expression, but it is less intense than in melanomas. Melanoma lines express both the pro- and the active form of catK |
681252 |
3.4.13.9 | Xaa-Pro dipeptidase |
melanoma cell |
higher expression of prolidase in tumor cells and particularly in melanoma cells |
683061 |
3.4.24.23 | matrilysin |
melanoma cell |
primary cutaneous and metastatic melanoma |
683312 |
3.4.24.7 | interstitial collagenase |
melanoma cell |
of invasive melanomas |
683330 |
3.4.13.9 | Xaa-Pro dipeptidase |
melanoma cell |
high enzyme expression level |
683964 |
3.4.24.24 | gelatinase A |
melanoma cell |
- |
684054, 752865 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
melanoma cell |
- |
685815 |
2.3.2.2 | gamma-glutamyltransferase |
melanoma cell |
GGT-overexpression in melanoma cells is associated with resistance to oxidative stress produced by prooxidant agents such as hydrogen peroxide and ascorbic acid |
686496 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
melanoma cell |
quantitative HO-1 expression analysis |
687181 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
melanoma cell |
- |
688812, 735724, 759316 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
melanoma cell |
parental mouse melanoma cell S91 6neo |
688812, 693954 |
2.7.7.49 | RNA-directed DNA polymerase |
melanoma cell |
- |
692248 |
2.7.8.27 | sphingomyelin synthase |
melanoma cell |
isozymes SMS1 and SMS2 |
692991 |
3.4.22.15 | cathepsin L |
melanoma cell |
- |
696091, 712921 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
melanoma cell |
- |
696397 |
7.3.2.7 | arsenite-transporting ATPase |
melanoma cell |
- |
697072 |
3.4.22.56 | caspase-3 |
melanoma cell |
expression patterns of the major caspases, CASP3, 6, 7, 8, 9, and 10, and inhibitor of apoptosis proteins, survivin, CIAP1, CIAP2, XIAP, and livin, overview |
698197 |
3.4.22.61 | caspase-8 |
melanoma cell |
expression patterns of the major caspases, CASP3, 6, 7, 8, 9, and 10, and inhibitor of apoptosis proteins, survivin, CIAP1, CIAP2, XIAP, and livin, overview |
698197 |
7.4.2.5 | bacterial ABC-type protein transporter |
melanoma cell |
- |
700137 |
3.4.22.56 | caspase-3 |
melanoma cell |
- |
700600 |
3.4.14.5 | dipeptidyl-peptidase IV |
melanoma cell |
- |
703784 |
5.3.1.9 | glucose-6-phosphate isomerase |
melanoma cell |
- |
704574 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
melanoma cell |
- |
705661 |
1.5.1.3 | dihydrofolate reductase |
melanoma cell |
DHFR is overexpressed in melanoma cells |
705800 |
5.3.3.12 | L-dopachrome isomerase |
melanoma cell |
levels of DCT are elevated in melanoma cell lines that are especially resistant to chemotherapy and radiation |
706613 |
3.2.2.29 | thymine-DNA glycosylase |
melanoma cell |
- |
706938, 751763 |
3.4.13.9 | Xaa-Pro dipeptidase |
melanoma cell |
high expression level |
707010 |
3.2.1.49 | alpha-N-acetylgalactosaminidase |
melanoma cell |
cutaneous melanoma, specific enzymatic activity of serum alpha-N-acetylgalactosaminidase is significantly increased in stage III melanoma patients, but not in early stages |
707963 |
3.4.22.54 | calpain-3 |
melanoma cell |
- |
708013 |
3.1.3.16 | protein-serine/threonine phosphatase |
melanoma cell |
- |
708789 |
3.4.22.36 | caspase-1 |
melanoma cell |
- |
709153 |
3.4.22.52 | calpain-1 |
melanoma cell |
- |
709406 |
4.4.1.5 | lactoylglutathione lyase |
melanoma cell |
- |
709815 |
3.4.24.B7 | matrix metalloproteinase-26 |
melanoma cell |
elevated MMP-26 expression level |
710794 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
melanoma cell |
- |
711107 |
3.4.25.1 | proteasome endopeptidase complex |
melanoma cell |
- |
711671 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
melanoma cell |
- |
713361 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
melanoma cell |
secrets the mature ATX |
713665 |
2.8.1.2 | 3-mercaptopyruvate sulfurtransferase |
melanoma cell |
- |
713731 |
5.6.2.1 | DNA topoisomerase |
melanoma cell |
- |
714760 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
melanoma cell |
diverse cell lines |
715720 |
3.1.1.64 | retinoid isomerohydrolase |
melanoma cell |
malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters into 11-cis retinol, whereas melanocytes are not able to catalyze these reactions |
715720 |
3.4.21.5 | thrombin |
melanoma cell |
- |
717955 |
3.4.24.B28 | ADAM15 |
melanoma cell |
melanocytes and endothelial cells of benign nevi and melanoma tissue |
718739 |
3.4.24.B9 | ADAM9 endopeptidase |
melanoma cell |
ADAM-9 is expressed in human melanoma at the tumor-stroma border where direct or indirect interactions between tumor cells and fibroblasts occur |
719997 |
3.4.24.B4 | matrix metalloproteinase-13 |
melanoma cell |
- |
650906, 720440 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
melanoma cell |
- |
721967 |
2.7.1.147 | ADP-specific glucose/glucosamine kinase |
melanoma cell |
- |
723169 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
melanoma cell |
- |
-, 725514, 742841 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
melanoma cell |
- |
726691 |
3.1.3.36 | phosphoinositide 5-phosphatase |
melanoma cell |
- |
730456 |
3.4.21.53 | Endopeptidase La |
melanoma cell |
- |
731618 |
3.4.21.112 | site-1 protease |
melanoma cell |
the enzyme SKI-1 is constitutively expressed in human pigment cells with higher SKI activity in seven out of eight melanoma cell lines compared with normal melanocytes, also detectable in tumor cells of melanoma metastases |
732292 |