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Synonyms
gcl, gamma-glutamylcysteine synthetase, glutamate-cysteine ligase, gamma-gcs, glutamate cysteine ligase, gamma-glutamylcysteine ligase, gamma-ecs, glclc, gammagcs, gamma-gc,
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bifunctional glutathione synthetase
bifunctional GSH synthetase
bifunctional L-glutathione synthetase
gamma-GCS-GS
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bifunctional enzyme accounts for gamma-glutamylcysteine synthetase and glutathione synthetase activities
gamma-glutamate-cysteine ligase-glutathione synthetase
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bifunctional enzyme
gamma-glutamate-cysteine ligase/glutathione synthetase
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bifunctional enzyme
gamma-glutaminylcysteine synthetase
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gamma-glutamycysteine synthetase
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gamma-glutamyl-cysteine ligase
gamma-Glutamyl-L-cysteine synthetase
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gamma-glutamylcysteine ligase
gamma-glutamylcysteine synthase
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gamma-Glutamylcysteine synthetase
gamma-glutamylcysteine synthetase-glutathione synthetase
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bifunctional enzyme
gamma-Glutamylcysteinyl-synthetase
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glutamate cysteine ligase
glutamate cysteine ligase gene
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glutamate-cysteine ligase
glutamate-cysteine-ligase
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glutamatecysteine ligase
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glutathione biosynthesis bifunctional protein GshAB
L-glutamate L-cysteine ligase
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Synthetase, gamma-glutamylcysteine
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Asuc_1947
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bifunctional glutathione synthetase
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bifunctional glutathione synthetase
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bifunctional GSH synthetase
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bifunctional GSH synthetase
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bifunctional L-glutathione synthetase
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bifunctional L-glutathione synthetase
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bifunctional L-glutathione synthetase
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bifunctional L-glutathione synthetase
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Gamma-ECS
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gamma-GCS
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gamma-GCS
Streptococcus agalactiae serogroup V ATCC BAA-611 / 2603 V/R
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gamma-glutamyl-cysteine ligase
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gamma-glutamyl-cysteine ligase
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gamma-glutamylcysteine ligase
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gamma-glutamylcysteine ligase
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gamma-glutamylcysteine ligase
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gamma-glutamylcysteine ligase
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gamma-glutamylcysteine ligase
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gamma-glutamylcysteine ligase
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gamma-glutamylcysteine ligase
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gamma-glutamylcysteine ligase
bifunctional enzyme, also glutathione synthetase activity, EC 6.3.2.3
gamma-glutamylcysteine ligase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
Streptococcus agalactiae serogroup V ATCC BAA-611 / 2603 V/R
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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gamma-Glutamylcysteine synthetase
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GCL
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GCL
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651392, 653993, 690385, 690387, 690630, 692205, 692442, 692444, 694060, 703592, 726668
GCLC
gene name, catalytic subunit
GCLC
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GCL catalytic subunit
GCLM
gene name, regulatory subunit
GCS
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GLCL
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glutamate cysteine ligase
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glutamate cysteine ligase
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glutamate cysteine ligase
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glutamate cysteine ligase
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glutamate cysteine ligase
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glutamate cysteine ligase
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glutamate cysteine ligase
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glutamate cysteine ligase
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glutamate cysteine ligase
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glutamate cysteine ligase
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glutamate cysteine ligase
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glutamate-cysteine ligase
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glutamate-cysteine ligase
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glutamate-cysteine ligase
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glutathione biosynthesis bifunctional protein GshAB
UniProt
glutathione biosynthesis bifunctional protein GshAB
UniProt
GSH1
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GshA
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gshAB
gene name, UniProt
gshAB
gene name, UniProt
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gshAB
Streptococcus agalactiae serogroup V ATCC BAA-611 / 2603 V/R
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gshAB
gene name, UniProt
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GshF
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GshF
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bifunctional enzyme gamma-glutamate-cysteine ligase-glutathione synthetase
GshF
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bifunctional gamma-glutamate-cysteine ligase/glutathione synthetase
GshF
Streptococcus agalactiae serogroup V ATCC BAA-611 / 2603 V/R
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GSHI
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PhGshA II
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PSHAa0937
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additional information
cf. EC 6.3.2.3
additional information
Streptococcus agalactiae serogroup V ATCC BAA-611 / 2603 V/R
cf. EC 6.3.2.3
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additional information
cf. EC 6.3.2.3
additional information
cf. EC 6.3.2.3
additional information
cf. EC 6.3.2.3
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additional information
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enzyme belongs to the superfamily of carboxylate-amine/ammonia ligases, together with glutathione synthase
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
partially random mechanism in which ATP is the obligatory first substrate and both amino acids bind in a random order to the enzyme*ATP complex. Formation of the enzyme*substrate quarternary complex is necessary prior to release of products
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
bi bi uni uni ping pong mechanism, with glutamyl-enzyme as intermediate before the addition of cys and the release of gamma-glutamylcysteine
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
tri tri sequential mechanism
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
reaction mechanism
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
reaction mechanism
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
Cys553 is not the active site residue
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
enzyme-bound reaction intermediate is a gamma-glutamyl-phosphate, active site cysteine, catalytic mechanism and substrate binding
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
enzyme-bound reaction intermediate is a gamma-glutamyl-phosphate, active site cysteine, catalytic mechanism, active site and substrate binding, Lys38 is an active site residue in the glutamyl binding site, His150 is essential for activity
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
enzyme-bound reaction intermediate is a gamma-glutamyl-phosphate, active site cysteine, mechanism
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
enzyme-bound reaction intermediate is a gamma-glutamyl-phosphate, active site cysteine, mechanism
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
enzyme-bound reaction intermediate is a gamma-glutamyl-phosphate, active site cysteine, mechanism
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
enzyme-bound reaction intermediate is a gamma-glutamyl-phosphate, active site cysteine, mechanism
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
no conserved cysteine residue in the active site
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
no conserved cysteine residue in the active site
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
rapid equilibrium random ter-reactant mechanism, substrate binding modeling, active site model
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
rapid equilibrium random ter-reactant mechanism, substrate binding modeling, Cys319 is an active site cysteine not essential for activity
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
reaction and kinetic mechanism, modeling
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
reaction mechanism via phosphorylated glutamate intermediate
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
substrate binding mechanism and catalytic site structure determination and analysis, Arg127 and conserved Cys249 are involved
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
reaction mechanism, overview
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
reaction mechanism
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ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
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ATP + alpha-ethyl-L-glutamate + L-alpha-aminobutyrate
ADP + phosphate + alpha-ethyl-L-glutamyl-L-alpha-aminobutyrate
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ir
ATP + alpha-methyl-DL-glutamate + L-alpha-aminobutyrate
ADP + phosphate + alpha-methyl-DL-glutamyl-L-alpha-aminobutyrate
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ir
ATP + alpha-methyl-L-glutamate + 2-aminobutyrate
ADP + phosphate + gamma-L-glutamyl-2-aminobutyrate
ATP + alpha-methyl-L-glutamate + L-alpha-aminobutyrate
ADP + phosphate + alpha-methyl-L-glutamyl-L-alpha-aminobutyrate
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ir
ATP + alpha-methylglutamate + L-Cys
ADP + phosphate + alpha-methylglutamyl-L-Cys
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i.e. 2-amino-2-methylpentanedioate
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ATP + beta-aminoglutarate + L-Cys
ADP + phosphate + beta-aminoglutaryl-L-Cys
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i.e. 3-aminopentanedioate
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ATP + beta-Glu + L-Cys
ADP + phosphate + beta-Glu-L-Cys
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17.6% of the activity relative to L-Glu
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?
ATP + beta-glutamate + L-alpha-aminobutyrate
ADP + phosphate + beta-glutamyl-L-alpha-aminobutyrate
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ir
ATP + beta-methyl-DL-glutamate + L-alpha-aminobutyrate
ADP + phosphate + beta-methyl-DL-glutamyl-L-alpha-aminobutyrate
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ir
ATP + beta-methylglutamate + L-Cys
ADP + phosphate + beta-methylglutamyl-L-Cys
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i.e. 2-amino-3-methylpentanedioate
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?
ATP + D-Glu + L-2-aminobutyrate
ADP + phosphate + gamma-D-Glu-L-alpha-aminobutyrate
ATP + D-Glu + L-alpha-aminobutyrate
ADP + phosphate + gamma-D-Glu-L-alpha-aminobutyrate
ATP + D-Glu + L-Cys
ADP + phosphate + D-Glu-L-Cys
ATP + DL-alpha-aminoadipate + L-cysteine
ADP + phosphate + DL-aminoadipyl-L-cysteine
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about 10% of the activity with L-glutamate
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?
ATP + DL-alpha-aminomethylglutarate + L-alpha-aminobutyrate
ADP + phosphate + DL-alpha-aminomethylglutaryl-L-alpha-aminobutyrate
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ir
ATP + DL-alpha-aminomethylsuccinate + L-alpha-aminobutyrate
ADP + phosphate + DL-alpha-aminomethylsuccinyl-L-alpha-aminobutyrate
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ATP + DL-beta-aminoadipate + L-alpha-aminobutyrate
ADP + phosphate + DL-beta-aminoadipyl-L-alpha-aminobutyrate
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ATP + glutamate + L-cysteine
ADP + phosphate + gamma-L-glutamyl-L-cysteine
random ter-reactant mechanism with a preferred binding order
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?
ATP + L-Glu
ADP + phosphate + 5-oxoproline
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ir
ATP + L-Glu + (R)-beta-amino-iso-butyrate
ADP + phosphate + gamma-L-Glu-(R)-beta-amino-iso-butyrate
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2fold less reactive as the S-isomer
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ir
ATP + L-Glu + (S)-beta-amino-iso-butyrate
ADP + phosphate + gamma-L-Glu-(S)-beta-amino-iso-butyrate
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2fold as reactive as the R-isomer
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ir
ATP + L-Glu + allo-L-threonine
ADP + phosphate + gamma-L-Glu-allo-L-threonine
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ir
ATP + L-Glu + beta-amino-iso-butyrate
ADP + phosphate + gamma-L-Glu-beta-amino-iso-butyrate
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ATP + L-Glu + beta-chloro-L-Ala
ADP + phosphate + gamma-L-Glu-L-beta-chloro-L-Ala
ATP + L-Glu + beta-chloro-L-alanine
ADP + phosphate + gamma-L-Glu-beta-chloro-L-alanine
ATP + L-Glu + beta-cyano-L-alanine
ADP + phosphate + gamma-L-Glu-beta-cyano-L-alanine
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ir
ATP + L-Glu + butylamine
ADP + phosphate + N-butyl-L-glutamine
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?
ATP + L-Glu + D-Cys
ADP + phosphate + gamma-L-Glu-D-Cys
ATP + L-Glu + DL-allylglycine
ADP + phosphate + gamma-L-Glu-DL-allylglycine
ATP + L-Glu + DL-beta-amino-iso-butyrate
ADP + phosphate + gamma-L-Glu-DL-beta-amino-iso-butyrate
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ir
ATP + L-Glu + ethylamine
ADP + phosphate + N-ethyl-L-glutamine
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?
ATP + L-Glu + gamma-aminobutyrate
ADP + phosphate + gamma-L-Glu-gamma-aminobutyrate
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mutant R366A
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r
ATP + L-Glu + gamma-aminobutyrate
ADP + phosphate + L-Glu-gamma-aminobutyrate
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ir
ATP + L-Glu + Gly
ADP + phosphate + gamma-L-Glu-Gly
ATP + L-Glu + hydroxylamine
ADP + phosphate + gamma-L-Glu-hydroxylamine
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slow reaction rate
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?
ATP + L-Glu + L-2-aminobutanoate
ADP + phosphate + gamma-L-Glu-2-aminobutanoate
ATP + L-Glu + L-2-aminobutyrate
ADP + phosphate + gamma-L-Glu-2-aminobutyrate
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?
ATP + L-Glu + L-2-aminobutyrate
ADP + phosphate + L-Glu-2-aminobutyrate
ATP + L-Glu + L-Ala
ADP + phosphate + gamma-L-Glu-L-Ala
ATP + L-Glu + L-alanine
ADP + phosphate + gamma-L-Glu-L-alanine
ATP + L-Glu + L-alpha-aminobutyrate
ADP + phosphate + gamma-L-Glu-L-alpha-aminobutyrate
ATP + L-Glu + L-alpha-aminoheptanoate
ADP + phosphate + gamma-L-Glu-L-alpha-aminoheptanoate
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ir
ATP + L-Glu + L-C-allylglycine
ADP + phosphate + gamma-L-Glu-L-C-allylglycine
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ir
6.3.2.2 glutamate-cysteine ligase
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