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Literature summary for 3.5.3.15 extracted from

  • Chang, X.; Han, J.
    Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors (2006), Mol. Carcinog., 45, 183-196.
    View publication on PubMed
Search for more literature for 3.5.3.15

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens peptidylarginine deiminase type 4 plays an essential role in pathogenesis of rheumatoid arthritis.Peptidylarginine deiminase type 4 may contribute to the disrupted apoptosis of tumors by caspase-mediated claevage of cytokeratin ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UM07
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Source Tissue

Source Tissue Comment Organism Textmining
adenocarcinoma cell strong expression by adenocarconoma from colon, gall bladder, lung, pancreas, thyroid, uterus, prostate, stomach, parotid, rectum, ovary, esophagus and duodenum, strong expression. Moderate expression by adenocarcinoma from small intestine Homo sapiens
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adenoma cell thyroid, moderate expression Homo sapiens
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astrocytoma cell brain, moderate expression Homo sapiens
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bladder transitional cell carcinoma cell moderate expression Homo sapiens
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breast fibroadenoma cell moderate expression Homo sapiens
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breast invasive ductal carcinoma cell moderate expression Homo sapiens
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cholangiocellular carcinoma cell strong expression Homo sapiens
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hepatoma cell strong expression Homo sapiens
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leiomyoma cell moderate expression Homo sapiens
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lung squamous cell carcinoma cell strong expression Homo sapiens
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lymphoma cell moderate expression Homo sapiens
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melanoma cell moderate expression Homo sapiens
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mesenchymal stem cell peptidylarginine deiminase type 4 is initially expressed in CD34+ cells of bone marrow and then distributed in derives of the multi-potent progenitor cells in diverse tissues Homo sapiens
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Non-Hodgkin's lymphoma cell strong expression Homo sapiens
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oral squamous cell carcinoma cell moderate expression Homo sapiens
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osteosarcoma cell strong expression Homo sapiens
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thecoma cell moderate expression Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information peptidylarginine deiminase type 4 plays an essential role in pathogenesis of rheumatoid arthritis.Peptidylarginine deiminase type 4 may contribute to the disrupted apoptosis of tumors by caspase-mediated claevage of cytokeratin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PAD4
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 Homo sapiens
peptidylarginine deiminase type 4
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 Homo sapiens