Information on EC 2.7.7.49 - RNA-directed DNA polymerase

Reaction Schemes

hideshow

a 2'-deoxyribonucleoside 5'-triphosphate

+

DNAn

=

diphosphate

+

DNAn+1

+

=

+

Synonyms
telomerase, reverse-transcriptase, telomerase reverse transcriptase, nucleoside reverse transcriptase, hiv-1 rt, hiv-1 reverse transcriptase, gag-pol, hiv reverse transcriptase, rna-dependent dna polymerase, telomerase catalytic subunit, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Bst DNA polymerase

Geobacillus stearothermophilus

E1C9K5

-

762052

CS5 pol

3 entries

DNA nucleotidyltransferase (RNA-directed)

-

-

-

-

DNA polymerase

3 entries

DNA polymerase I

3 entries

FeLV RT

feline leukemia virus

-

-

663444

FIV RT

feline immunodeficiency virus

-

-

663444

FV Pol

2 entries

FV reverse transcriptase

Simian foamy virus

-

-

723752

Gag-Pol

Human immunodeficiency virus 1

-

reverse transcriptase precursor

695261

HBV-pol

Hepatitis B virus

-

-

721786

HIV reverse transcriptase

Human immunodeficiency virus 1

-

-

721995

HIV-1 M RT

Human immunodeficiency virus 1

-

-

721311

HIV-1 O RT

Human immunodeficiency virus 1

-

-

721311

HIV-1 R

Human immunodeficiency virus 1

-

-

716827

HIV-1 reverse transcriptase

4 entries

HIV-1 RT

4 entries

HIV-reverse transcriptase

Human immunodeficiency virus 1

-

-

723783

HIV-RT

Human immunodeficiency virus 1

-

-

723783

human hepatitis B virus polymerase

Hepatitis B virus

-

-

721786

human immunodeficiency virus type 1 reverse transcriptase

Human immunodeficiency virus 1

-

-

716827, 721311

iScript enzyme

Moloney murine leukemia virus

-

commercial name

692219

K4 polymerase

2 entries

K4PolI

2 entries

M-MuLV reverse transcriptase

Moloney murine leukemia virus

-

-

723690

MMLV RT

Moloney murine leukemia virus

-

-

721311, 721508

Moloney Murine leukemia virus reverse transcriptase

Moloney murine leukemia virus

-

-

723690

Moloney murine leukemia virus RT

Moloney murine leukemia virus

-

-

721311, 723292

MoMLV RT

Moloney murine leukemia virus

-

-

723292

MuLV RT

murine leukemia virus

-

-

662344

MX162-RT

-

-

-

-

MX65-RT

-

-

-

-

nucleoside reverse transcriptase

Homo sapiens

-

-

692567

nucleotidyltransferase, deoxyribonucleate, RNA-dependent

-

-

-

-

p66 RT

Human immunodeficiency virus 1

-

-

672230

P72

-

-

-

-

PFV RT

prototype foamy virus

-

-

723752

Pol

Human immunodeficiency virus 1

O12158

-

690315

polymerase/reverse transcriptase

Hepatitis B virus

-

-

721786

prototype foamy virus reverse transcriptase

prototype foamy virus

-

-

723752

R2-RT

Bombyx mori

-

-

675338

reverse transcriptase

35 entries

reverse transcriptase/RNA dependent DNA polymerase

Hepatitis B virus

-

-

721786

reverse-transcriptase

Human immunodeficiency virus 1

-

-

692252

revertase

-

-

-

-

RNA dependent DNA polymerase

Human immunodeficiency virus 1

-

-

694787

RNA revertase

-

-

-

-

RNA-dependent DNA polymerase

5 entries

RNA-instructed DNA polymerase

-

-

-

-

RT

3 entries

SFV RT

Simian foamy virus

-

-

723752

simian foamy virus reverse transcriptase

Simian foamy virus

-

-

723752

SS RT

Human immunodeficiency virus 1

-

-

662652

SuperScript I reverse transcriptase

Moloney murine leukemia virus

-

commercial preparation

693484

Superscript II

Moloney murine leukemia virus

-

commercial preparation

693960

SUPERSCRIPT II reverse transcriptase

2 entries

T. Z05 pol

3 entries

telomerase

7 entries

telomerase catalytic subunit

-

-

-

-

telomerase reverse transcriptase

7 entries

TERT

7 entries

Tgo-Pol

Thermococcus gorgonarius

-

-

722045

xenotropic murine leukemia virus-related virus reverse transcriptase

Xenotropic MuLV-related virus

A1Z651

-

723292

XMRV RT

Xenotropic MuLV-related virus

A1Z651

-

723292

XNA reverse transcriptase

Geobacillus stearothermophilus

E1C9K5

-

762052

additional information

4 entries

CS5 pol

Thermotoga maritima

-

chimeric DNA polymerase, termed CS5 pol, constructed from T. Z05 pol and Tma pol

672087

CS5 pol

Thermus sp.

-

chimeric DNA polymerase, termed CS5 pol, constructed from T. Z05 pol and Tma pol

672087

CS5 pol

Thermus sp. Z05

-

chimeric DNA polymerase, termed CS5 pol, constructed from T. Z05 pol and Tma pol

-

DNA polymerase

Human immunodeficiency virus 1

-

-

714972

DNA polymerase

Human immunodeficiency virus 2

-

-

692353

DNA polymerase

Thermus thermophilus

-

-

692492

DNA polymerase I

Streptococcus agalactiae

-

-

691131

DNA polymerase I

Streptococcus agalactiae NEM316

-

-

-

DNA polymerase I

Thermus aquaticus

-

-

723163

FV Pol

prototype foamy virus

-

-

723752

FV Pol

Simian foamy virus

-

-

723752

HIV-1 reverse transcriptase

Human immunodeficiency virus 1

-

-

714972, 716827, 721138, 723042, 723089, 723239

HIV-1 reverse transcriptase

Human immunodeficiency virus 1

AF324493, Q8Q2U5, Q8Q2V9

-

723753

HIV-1 reverse transcriptase

Human immunodeficiency virus 1 BG05

Q8Q2U5

-

-

HIV-1 reverse transcriptase

Human immunodeficiency virus 1 M01

Q8Q2V9

-

-

HIV-1 RT

Human immunodeficiency virus 1

-

-

663342, 676214, 714972, 723042, 723239, 723294

HIV-1 RT

Human immunodeficiency virus 1

AF324493, Q8Q2U5, Q8Q2V9

-

723753

HIV-1 RT

Human immunodeficiency virus 1 BG05

Q8Q2U5

-

-

HIV-1 RT

Human immunodeficiency virus 1 M01

Q8Q2V9

-

-

K4 polymerase

Thermotoga petrophila

-

-

722837

K4 polymerase

Thermotoga petrophila K4

-

-

-

K4PolI

Thermotoga petrophila

-

-

722837

K4PolI

Thermotoga petrophila K4

-

-

-

reverse transcriptase

-

-

-

-

reverse transcriptase

Avian myeloblastosis virus

-

-

695237

reverse transcriptase

Avian myeloblastosis virus

-

multifunctional enzyme but mainly used as RNA-directed DNA polymerase

703356

reverse transcriptase

badnavirus

-

-

690652

reverse transcriptase

bovine immunodeficiency virus

-

-

695250, 722241

reverse transcriptase

Candida albicans

-

-

692628

reverse transcriptase

caulimovirus

-

-

690652

reverse transcriptase

cavemovirus

-

-

690652

reverse transcriptase

feline immunodeficiency virus

-

-

693897

reverse transcriptase

Hepatitis B virus

-

-

693435, 721786, 760782

reverse transcriptase

Homo sapiens

-

-

691140

reverse transcriptase

Human Immunodeficiency Virus

-

-

692712, 692794, 694265, 694343, 694561, 694803

reverse transcriptase

Human immunodeficiency virus 1

-

-

690316, 690317, 691234, 691261, 691778, 691942, 692800, 693371, 693910, 721311, 722241, 761475, 761495, 761679, 761733

reverse transcriptase

Human immunodeficiency virus 1

-

exhibits DNA polymerase activity and RNase H activity

695260

reverse transcriptase

Human immunodeficiency virus 1

-

reverse transcriptase is synthesized as part of the Gag-Pol precursor protein, which is cleaved by the virally encoded protease into the structural proteins and the replication enzymes reverse transcriptase, protease, and integrase

695261

reverse transcriptase

Human immunodeficiency virus 1

O12158

-

690315

reverse transcriptase

Human immunodeficiency virus 1

P03366

-

694443, 762335

reverse transcriptase

Human immunodeficiency virus 1

P04585

-

762343

reverse transcriptase

Human immunodeficiency virus 2

-

-

695245

reverse transcriptase

Human immunodeficiency virus 2

-

reverse transcriptases of retroviruses have two enzymatic activities, a DNA polymerase (that copies both RNA and DNA templates) and the ribonuclease H activity that hydrolyzes the RNA in DNA-RNA hybrids, the ribonuclease H level of HIV-2 RT is lower than that of HIV-1 reverse transcriptase, while the DNA polymerase of both reverse transcriptases is similar

692353

reverse transcriptase

Moloney murine leukemia virus

-

-

681096, 691513, 692219, 693960, 694030, 721311

reverse transcriptase

Moloney murine leukemia virus

-

multifunctional enzyme but mainly used as RNA-directed DNA polymerase

703356

reverse transcriptase

murine leukemia virus

-

-

693898, 722241

reverse transcriptase

petuvirus

-

-

690652

reverse transcriptase

Pseudomonas aeruginosa

-

-

690537

reverse transcriptase

Saccharomyces cerevisiae

-

-

691122

reverse transcriptase

Simian immunodeficiency virus

-

-

695248

reverse transcriptase

Simian immunodeficiency virus - mac

-

-

761517

reverse transcriptase

Simian immunodeficiency virus - mac 239

-

-

-

reverse transcriptase

Simian immunodeficiency virus mneCl8

-

-

-

reverse transcriptase

soymovirus

-

-

690652

reverse transcriptase

Thermococcus gorgonarius

-

-

722045

reverse transcriptase

Thermotoga petrophila

-

-

722837

reverse transcriptase

Thermotoga petrophila K4

-

-

-

reverse transcriptase

tungrovirus

-

-

690652

RNA-dependent DNA polymerase

-

-

-

-

RNA-dependent DNA polymerase

Avian myeloblastosis virus

-

-

703356

RNA-dependent DNA polymerase

Moloney murine leukemia virus

-

-

703356

RNA-dependent DNA polymerase

Streptococcus agalactiae

-

-

691131

RNA-dependent DNA polymerase

Streptococcus agalactiae NEM316

-

-

-

RT

-

-

-

-

RT

Human immunodeficiency virus 1

-

-

721311

RT

Moloney murine leukemia virus

-

-

721311

SUPERSCRIPT II reverse transcriptase

Moloney murine leukemia virus

-

-

695179

SUPERSCRIPT II reverse transcriptase

Moloney murine leukemia virus

-

commercial preparation

693073

T. Z05 pol

Thermotoga maritima

-

-

672087

T. Z05 pol

Thermus sp.

-

-

672087

T. Z05 pol

Thermus sp. Z05

-

-

-

telomerase

Homo sapiens

-

-

692248, 693914, 694207, 695224

telomerase

Homo sapiens

-

telomerase is composed of three essential components: the telomerase reverse transcriptase, the telomerase RNA component, and the TERC-binding protein dyskerin

691981

telomerase

Homo sapiens

-

telomerase lengthens telomeres by its reverse transcriptase activity

691140

telomerase

Homo sapiens

-

telomeres are synthesized and maintained by telomerase, a heterodimeric enzyme with an RNA template subunit (TERC) and a catalytic protein component (TERT)

691152

telomerase

Mus musculus

-

-

691689

telomerase

Rattus norvegicus

-

-

693268

telomerase

Saccharomyces cerevisiae

-

-

674823, 691122

telomerase reverse transcriptase

-

-

-

-

telomerase reverse transcriptase

Canis lupus familiaris

Q6A548

-

693964

telomerase reverse transcriptase

Homo sapiens

-

-

691632, 691882, 691981, 692539, 692555, 692580, 692582, 693312, 694309, 694504, 695141

telomerase reverse transcriptase

Homo sapiens

-

catalytic subunit of telomerase

692248

telomerase reverse transcriptase

Human immunodeficiency virus 1

-

-

693584

telomerase reverse transcriptase

Mus musculus

-

-

691689, 694324

telomerase reverse transcriptase

Oryzias latipes

-

-

691920

TERT

Canis lupus familiaris

Q6A548

catalytic subunit of telomerase

693964

TERT

Homo sapiens

-

-

691140, 691632, 691882, 691981, 692248, 692539, 692555, 692580, 692582, 693312, 694207, 694309, 694504, 695141, 695224

TERT

Homo sapiens

-

catalytic protein component of telomerase

691152

TERT

Human immunodeficiency virus 1

-

-

693584

TERT

Mus musculus

-

-

691689, 694324

TERT

Oryzias latipes

-

-

691920

TERT

Rattus norvegicus

-

catalytic subunit of telomerase

693268

additional information

Streptomyces coelicolor

-

DNA polymerase (PolA) and topoisomerase I (TopA) proteins exhinit highly efficient reverse transcriptase activity in addition to their predicted functions

663213

additional information

Streptomyces coelicolor M145

-

DNA polymerase (PolA) and topoisomerase I (TopA) proteins exhinit highly efficient reverse transcriptase activity in addition to their predicted functions

-

additional information

[Caldibacillus] cellulovorans

-

DNA polymerase with reverse-transcriptase activity

661676

additional information

[Caldibacillus] cellulovorans CompA.2

-

DNA polymerase with reverse-transcriptase activity

-

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1

-

-

-

-

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

nucleotidyl group transfer

-

-

-

-

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SYSTEMATIC NAME

IUBMB Comments

deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)

Catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC 2.7.7.7 DNA-directed DNA polymerase.

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CAS REGISTRY NUMBER

COMMENTARY

9068-38-6

-

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