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Literature summary for 2.7.1.107 extracted from

  • Yanagisawa, K.; Yasuda, S.; kai, M.; Imai, S.i.; Yamada, K.; Yamashita, T.; JImbow, K.; Kanoh, H.; Sakane, F.
    Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation (2007), Biochim. Biophys. Acta, 1771, 462-474.
    View publication on PubMed

Application

Application Comment Organism
medicine overexpression of wild-type diacylglycerol kinase alpha, but not of its kinase-dead mutant, markedly suppresses tumor necrosis factor alpha-induced apoptosis of AKI human melanoma cells and enhances the tumor necrosis factor alpha-stimulated transcriptional activity of transcription factor NF-kappaB. siRNA-mediated knock-down of diacylglycerol kinase alpha enhances the apoptosis. Overexpression of isoforms beta and gamma has no detectable effect on apoptosis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of wild-type diacylglycerol kinase alpha, but not of its kinase-dead mutant, markedly suppresses tumor necrosis factor alpha-induced apoptosis of AKI human melanoma cells and enhances the tumor necrosis factor alpha-stimulated transcriptional activity of transcription factor NF-kappaB. siRNA-mediated knock-down of diacylglycerol kinase alpha enhances the apoptosis. Overexpression of isoforms beta and gamma has no detectable effect on apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Homo sapiens P23743
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-

Source Tissue

Source Tissue Comment Organism Textmining
melanoma cell
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Homo sapiens
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melanoma cell expression of isoform diacylglycerol kinase alpha in several melanoma cell lines but not in noncancerous melanocytes Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
diacylglycerol kinase alpha
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Homo sapiens