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Literature summary for 3.1.4.39 extracted from

  • Yuelling, L.M.; Fuss, B.
    Autotaxin (ATX): a multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties (2008), Biochim. Biophys. Acta, 1781, 525-530.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.39

Inhibitors

Inhibitors Comment Organism Structure
lysophosphatic acid inhibits at biologically relevant concentrations Homo sapiens
sphingosine 1-phosphate inhibits at biologically relevant concentrations Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information affinity for lysophosphatidylcholine is significantly higher than for nucleotides Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
125000
-
 calculated from cDNA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lysophosphatidylcholine + H2O Homo sapiens
-
 lysophosphatidic acid + choline
-
 ?
additional information Homo sapiens activity implicated in a large variety of biological processes (during normal development and under pathological conditions). Developmental roles include adipogenesis, intestinal cell motility and neurite morphology, a contribution to disease is described for alzheimer's disease, chronic hepatitis C, multiple sclerosis, neuropathic pain, obesity, rheumatoid arthritis ?
-
 ?
sphingosylphosphorylcholine + H2O Homo sapiens
-
 sphingosine 1-phosphate + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein ATX is synthesized as pre-pro-enzyme and secreted upon removal of the N-terminal signal peptide and further trimming by a furine-type protease Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma high phosphodiesterase Ialpha/autotoxin levels Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
cerebrospinal fluid high phosphodiesterase Ialpha/autotoxin levels Homo sapiens
-
glioblastoma cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
neuroblastoma cell
-
 Homo sapiens
-
non-small cell lung cancer cell
-
 Homo sapiens
-
prostate cancer cell line
-
 Homo sapiens
-
renal cell carcinoma cell
-
 Homo sapiens
-
thyroid cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lysophosphatidylcholine + H2O
-
 Homo sapiens lysophosphatidic acid + choline
-
 ?
additional information activity implicated in a large variety of biological processes (during normal development and under pathological conditions). Developmental roles include adipogenesis, intestinal cell motility and neurite morphology, a contribution to disease is described for alzheimer's disease, chronic hepatitis C, multiple sclerosis, neuropathic pain, obesity, rheumatoid arthritis Homo sapiens ?
-
 ?
sphingosylphosphorylcholine + H2O
-
 Homo sapiens sphingosine 1-phosphate + choline
-
 ?

Subunits

Subunits Comment Organism
? domains discovered are adjacent somatomedin B-like domain, nuclease-like domain and a single EF hand-like motif, modulator of oligodendrocyte remodeling and focal adhesion organization (MORFO) domain is located at the C-terminal end of the protein and entails the nuclease-like domain not thought to be catalytically active and functions independently of ATX's enzymatic activity Homo sapiens

Synonyms

Synonyms Comment Organism
(ecto)nucleotide pyrophosphatase/phosphodiesterase 2 [(E)NPP2] multi-functional and multi-modular, 3 splice variants/isoforms of ATX identified in both human and mouse (autotaxin alpha, beta and gamma, with autotaxin gamma being identical to PD-Ialpha) Homo sapiens
PD-Ialpha/ATX multi-functional and multi-modular, 3 splice variants/isoforms of ATX identified in both human and mouse (autotaxin alpha, beta and gamma, with autotaxin gamma being identical to PD-Ialpha) Homo sapiens
phosphodiesterase Ialpha/autotoxin multi-functional and multi-modular, 3 splice variants/isoforms of ATX identified in both human and mouse (autotaxin alpha, beta and gamma, with autotaxin gamma being identical to phosphodiesterase Ialpha) Homo sapiens