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Information on EC 2.4.3.1 - beta-galactoside alpha-(2,6)-sialyltransferase
for references in articles please use BRENDA:EC2.4.3.1
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EC Tree 2 Transferases
2.4 Glycosyltransferases
2.4.3 Sialyltransferases
2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase
IUBMB Comments
The enzyme acts on the terminal non-reducing β-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
st6gal i, st6gal1, alpha 2,6-sialyltransferase, st6gal-1, st6gal, alpha-2,6-sialyltransferase, st6galnac2, st6gali, siat1, alpha 2,6-st, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha2,6-sialyltransferase 5
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6STase
alpha 2,6-sialyltransferase
alpha 2,6-ST
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alpha(2,6)-sialyltransferase
alpha(2,6)-ST
alpha-(2->6)-sialyltransferase
alpha-2,6-sialyltransferase
alpha2,6 sialyltransferase
alpha2,6-sialyltransferase
alpha2,6-ST
alpha2-6 sialyltransferase
antigens, CD75
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B-cell antigen CD75
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beta-galactoside alpha-2,6-sialyltransferase
beta-galactoside alpha2,6-sialyltransferase
beta-galactoside alpha2-6-sialyltransferase-1
CMP-acetylneuraminate-galactosylglycoprotein sialyltransferase
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CMP-acetylneuraminate-glycoprotein sialyltransferase
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CMP-acetylneuraminate-lactosylceramide-sialyltransferase
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-
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CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine alpha-(2->6)-N-acetylneuraminyltransferase
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CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase
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CMP-N-acetylneuraminic acid-glycoprotein sialyltransferase
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CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase
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CMP-sialic acid:lactosylceramide sialyltransferase
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cytidine monophosphoacetylneuraminate-galactosylglycoprotein sialyltransferase
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cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase
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EC 2.4.99.1
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formerly
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EC 2.4.99.11
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formerly
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GM3-synthase
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HAC1268
lactosylceramide alpha-2,6-N-sialyltransferase
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sialotransferase
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sialyltransferase
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sialyltransferase, cytidine monophosphoacetylneuraminate-galactosylglycoprotein
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sialyltransferase, cytidine monophosphoacetylneuraminate-lactosylceramide
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ST6Gal
ST6Gal I
ST6Gal II
ST6Gal-1
ST6Gal-I
ST6Gal1
additional information
alpha2-6 sialyltransferase
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-
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-
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
mechanism
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CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
The terminal beta-D-galactosyl residue of the oligosaccharide of glycoproteins, as well as lactose, can act as acceptor
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CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Val220 participates in binding the common cytidine moiety in substrate CMP-NeuAc and inhibitor CDP
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
glycosyl group transfer
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-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
complex N-linked glycan biosynthesis (vertebrates), ganglio-series glycosphingolipids biosynthesis, lacto-series glycosphingolipids biosynthesis, neolacto-series glycosphingolipids biosynthesis, terminal O-glycans residues modification (via type 2 precursor disaccharide)
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SYSTEMATIC NAME
IUBMB Comments
CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)
The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.
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CAS REGISTRY NUMBER
COMMENTARY
55071-95-9
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9075-81-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
asialo-alpha1-acidglycoprotein + CMP-Neu5Ac
?
Substrates: membrane-bound and soluble protein, 34% and 25% relative activity, respectively
Products: -
Products: -
?
CMP-9''-benzamido-Neu5Ac + N-acetyllactosamine
?
-
Substrates: -
Products: -
Products: -
?
CMP-9''-phenylacetamido-Neu5Ac + N-acetyllactosamine
?
-
Substrates: -
Products: -
Products: -
?
CMP-9''-phenylhexanamido-Neu5Ac + N-acetyllactosamine
?
-
Substrates: -
Products: -
Products: -
?
CMP-9''-phenylpropionamido-Neu5Ac + lactose
?
-
Substrates: -
Products: -
Products: -
?
CMP-9''-phenylpropionamido-Neu5Ac + N-acetyllactosamine
?
-
Substrates: -
Products: -
Products: -
?
CMP-9-acetamido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
Substrates: -
Products: -
Products: -
?
CMP-9-amino-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
Substrates: -
Products: -
Products: -
?
CMP-9-azido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
Substrates: -
Products: -
Products: -
?
CMP-9-benzamido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
Substrates: -
Products: -
Products: -
?
CMP-9-fluoresceinyl-N-acetylneuraminate + asialofetuin
?
Substrates: -
Products: -
Products: -
?
CMP-9-hexanoylamido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
Substrates: -
Products: -
Products: -
?
CMP-9-O-acetyl-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
CMP + ?
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetyl-beta-neuraminate + alpha-1-antitrypsin
CMP + ?
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + fetuin
Substrates: -
Products: -
Products: -
?
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R
CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
CMP-N-acetyl-beta-neuraminate + desialylated fetuin
CMP + ?
Substrates: -
Products: -
Products: -
?
CMP-N-acetyl-beta-neuraminate + integrin-beta1
CMP + ?
Substrates: -
Products: -
Products: -
?
CMP-N-acetyl-beta-neuraminate + intercellular adhesion molecule-1
CMP + ?
-
Substrates: the enzyme can increase the stability of intercellular adhesion molecule-1 through sialylation
Products: -
Products: -
?
CMP-N-acetyl-beta-neuraminate + methyl beta-D-N-acetyllactosaminide
CMP + methyl alpha-N-acetylneuraminyl-(2->6)-beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucopyranoside
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetyl-beta-neuraminate + N-acetyllactosamin-butyl
CMP + ?
Substrates: -
Products: -
Products: -
?
CMP-N-acetyl-beta-neuraminate + PrPSc
CMP + ?
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Substrates: brain-, spleen- and N2a-cell-derived PrPSc is predominantly 2,6-sialylated
Products: -
Products: -
?
CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
CMP + ?
CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methylamide
CMP + ?
-
Substrates: 0.2% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
?
CMP-N-acetylneuraminate + (Gal-3-O-Me)beta(1-3)(GlcNAc-6-O-Me)beta-O-Me
CMP + ?
-
Substrates: 50% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
?
CMP-N-acetylneuraminate + (Gal-3-O-Me)beta(1-3)GlcNAcbeta-O-Me
CMP + ?
-
Substrates: 80% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
?
CMP-N-acetylneuraminate + (Galbeta(1,4))2(GlcNAcbeta(1,2))2(Man)3(GlcNAc)2-Asn-Fmoc
?
-
Substrates: 34.9 activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
Products: -
Products: -
?
CMP-N-acetylneuraminate + (GalNAcbeta(1,4))2(GlcNAcbeta(1,2))2(Man)3(GlcNAc)2-Asn-Fmoc
?
-
Substrates: 140 activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
Products: -
Products: -
?
CMP-N-acetylneuraminate + 4-methylumbelliferyl beta-D-lactoside
?
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + 4-nitrophenyl beta-D-galactopyranosyl-(1->3)-N-acetyl-beta-D-glucosaminide
CMP + 4-nitrophenyl N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactopyranosyl-(1->3)-N-acetyl-beta-D-glucosaminide
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Substrates: 2.5% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
Products: -
Products: -
?
CMP-N-acetylneuraminate + 4-nitrophenyl beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
CMP + 4-nitrophenyl N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
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Substrates: 100% activity
Products: -
Products: -
?
CMP-N-acetylneuraminate + 4-nitrophenyl N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
CMP + 4-nitrophenyl N-acetyl-alpha-neuraminyl-(2->6)-N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
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Substrates: best acceptor with 371.5% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
Products: -
Products: -
?
CMP-N-acetylneuraminate + 4-nitrophenyl-D-galactoside
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-(4-nitro)phenol
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + 5-(5-dimethylaminonaphthalene-1-sulfonyl-2-(2-aminoethoxy))ethyl beta-lactose
CMP + ?
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + 5-(5-dimethylaminonaphthalene-1-sulfonyl-2-(2-aminoethoxy))ethyl beta-N-acetyllactosamine
CMP + 5-(5-dimethylaminonaphthalene-1-sulfonyl-2-(2-aminoethoxy)) ethyl beta-N-acetylneuraminic acid alpha-2,6-N-acetyllactosamine
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + 6'-sialyl-N-acetyl-D-lactosamine
?
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + alpha1-acid glycoprotein
CMP + ?
-
Substrates: 20.6% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialo-agalacto-prothrombin
CMP + agalacto-prothrombin
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
CMP + ?
-
Substrates: 12.3% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialo-apoceruloplasmin
CMP + apoceruloplasmin
-
Substrates: best substrate
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialo-chorionic gonadotropin
CMP + chorionic gonadotropin
-
Substrates: acceptor protein from human source
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialo-fibrinogen
CMP + fibrinogen
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialo-immunoglobulin G
CMP + immunoglobulin G
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialo-immunoglobulin M
CMP + immunoglobulin M
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialo-proteose peptone
CMP + proteose peptone
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialo-Tamm-Horsfall glycoprotein
CMP + Tamm-Horsfall glycoprotein
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialo-thyroglobulin glycopeptide
CMP + thyroglobulin glycopeptide
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + asialoovomucoid
CMP + ?
-
Substrates: 9.1% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosamine
Drosophila sp. (in: flies)
-
Substrates: 36% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine-R
Drosophila sp. (in: flies)
-
Substrates: exhibits highest activity toward GalNAcbeta1,4GlcNAc carbohydrate structures at the non-reducing termini of oligosaccharides and glycoprotein glycans. Oligosaccharides are preferred over glycoproteins as acceptors, and no activity toward glycolipid acceptors is detected. Recombinant Drosophila SiaT expressed in cultured insect cells possesses in vivo and in vitro autosialylation activity toward beta-linked GalNAc termini of its own N-linked glycans
Products: -
Products: -
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,2-alpha-mannosyl-1,6-beta-mannosyl-1,4-N-acetylglucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,2-alpha-mannosyl-1,6-beta-mannosyl-1,4-N-acetylglucosamine
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,4-beta-D-galactosyl-1,4-beta-D-glucosyl-beta1-ceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,4-beta-D-galactosyl-1,4-beta-D-glucosyl-beta1-ceramide
-
Substrates: i.e. paragloboside
Products: i.e. alpha-2,6-sialylparagloboside
Products: i.e. alpha-2,6-sialylparagloboside
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP-N-acetylneuraminate + formic acid (2R,3R,4S,5R,6R)-2-((2R,3R,4R,5R,6R)-3-acetylamino-5-hydroxy-2-methoxy-6-methylaminomethyl-tetrahydro-pyran-4-yloxy)-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl ester
CMP + ?
-
Substrates: as active as Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
?
CMP-N-acetylneuraminate + fucosyl-alpha-1,2-D-galactosyl-beta-1,4-D-glucose
?
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + fucosyllactose
CMP + alpha-N-acetylneuraminyl-2,6-[alpha-L-fucopyranosyl-1,2]-beta-D-galactopyranosyl-1,4-D-glucopyranose
-
Substrates: also pyridylaminated
Products: -
Products: -
?
CMP-N-acetylneuraminate + Gal-beta-1,3-GlcNAc-beta-OMe
?
Substrates: 77% of the activity with lactose
Products: -
Products: -
?
CMP-N-acetylneuraminate + Galbeta(1-3)(GlcNAc-6-O-Me)beta-O-Me
CMP + ?
-
Substrates: 80% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
?
CMP-N-acetylneuraminate + Galbeta(1-3)-GlcNAcbeta(1-3)Galbeta(1-4)Glc
CMP + NeuNAcalpha(2-6)-Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc
Drosophila sp. (in: flies)
-
Substrates: 30% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
?
CMP-N-acetylneuraminate + Galbeta(1-3)GlcNAcbeta-O-Me
CMP + NeuAcalpha(2-6)Galbeta(1-3)GlcNAcbeta-O-Me
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc
CMP + alpha-N-acetylneuraminyl-(2-6)Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc
Drosophila sp. (in: flies)
-
Substrates: 79% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
?
CMP-N-acetylneuraminate + Galbeta(1->3)GalNAc
CMP + NeuAcalpha(2->6)Galbeta(1->3)GalNAc
Substrates: 10% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
?
CMP-N-acetylneuraminate + Galbeta(1->3)GlcNAc
CMP + NeuAcalpha(2->6)Galbeta(1->3)GlcNAc
Substrates: 2% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
?
CMP-N-acetylneuraminate + Galbeta(1->4)GlcNAcbeta(1->2)Manalpha(1->6)[Galbeta(1->4)GlcNAcbeta(1>2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-pyridylamine
CMP + NeuAcalpha(2->6)Galbeta(1->4)GlcNAcbeta(1->2)Manalpha(1->6)[Galbeta(1->4)GlcNAcbeta(1>2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-pyridylamine
-
Substrates: -
Products: -
Products: -
?
CMP-N-acetylneuraminate + Galbeta(1->4)GlcNAcbeta(1->3)Galbeta(1->4)Glcbeta(1<->1)ceramide
CMP + NeuAcalpha(2->6)Galbeta(1->4)GlcNAcbeta(1->3)Galbeta(1->4)Glcbeta(1<->1)ceramide
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Substrates: -
Products: -
Products: -
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CMP-N-acetylneuraminate + Galbeta-4-nitrophenyl
?
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Substrates: 26.4% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
Products: -
Products: -
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CMP-N-acetylneuraminate + GalNAcbeta-4-nitrophenyl
?
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Substrates: 120.4% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
Products: -
Products: -
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CMP-N-acetylneuraminate + GalNAcbeta1,4-GlcNAc-R
CMP + alpha-N-acetylneuraminyl-2,6-GalNAcbeta1,4-GlcNAc-R
Drosophila sp. (in: flies)
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Substrates: -
Products: 190% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: 190% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
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CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
Substrates: -
Products: -
Products: -
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CMP-N-acetylneuraminate + lacto-N-neotetraose
CMP + ?
Substrates: 108% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
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CMP-N-acetylneuraminate + lactose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucose
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Substrates: 15.5% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
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CMP-N-acetylneuraminate + methanesulfonic acid (2R,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylmethyl ester
CMP + ?
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Substrates: 90% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
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CMP-N-acetylneuraminate + methyl-alpha-D-galactopyranoside
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Substrates: 2% of the activity with lactose
Products: -
Products: -
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CMP-N-acetylneuraminate + methyl-beta-D-galactopyranoside
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Substrates: 59% of the activity with lactose
Products: -
Products: -
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CMP-N-acetylneuraminate + methyl-beta-D-galactopyranoside
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-methylgalactopyranoside
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Substrates: -
Products: -
Products: -
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CMP-N-acetylneuraminate + N-((1R,3R,5R,6R,7S,8R,13R,15R,16R,17S)-6,7,17-trihydroxy-5-hydroxymethyl-15-methoxy-2,4,9,11,14-pentaoxa-tricyclo[11.3.1.03,8]heptadec-16-yl)-acetamide
CMP + ?
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Substrates: as active as Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
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CMP-N-acetylneuraminate + N-((1R,3R,5R,6R,7S,8R,14R,16R,17R,18R)-6,7,18-trihydroxy-5-hydroxymethyl-16-methoxy-11-oxo-2,4,9,15-tetraoxa-12-aza-tricyclo[12.3.1.03,8]octadec-17-yl)-acetamide
CMP + ?
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Substrates: 110% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
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CMP-N-acetylneuraminate + N-((1R,3R,5R,6R,7S,8R,14R,16R,17R,18S)-6,7,18-trihydroxy-5-hydroxymethyl-16-methoxy-2,4,9,12,15-pentaoxa-tricyclo[12.3.1.03,8]octadec-17-yl)-acetamide
CMP + ?
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Substrates: 130% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
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CMP-N-acetylneuraminate + N-acetyl-D-galactosamine
?
Substrates: 12% of the activity with lactose
Products: -
Products: -
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CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-4-hydroxy-6-(methanesulfonylamino-methyl)-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
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Substrates: 70% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
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CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-5-((2S,3R,4S,5R,6R)-4,5-dihydroxy-6-hydroxymethyl-3-methoxy-tetrahydro-pyran-2-yloxy)-6-formylaminomethyl-4-hydroxy-2-methoxy-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
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Substrates: as active as Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
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CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-6-(acetylamino-methyl)-4-hydroxy-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
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Substrates: 60% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
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CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-6-aminomethyl-4-hydroxy-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
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Substrates: 50% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
Products: -
Products: -
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CMP-N-acetylneuraminate + Neu5Acalpha-2,3-Galbeta-1,4-Glc
CMP + alpha-N-acetylneuraminyl-2,6-(Neu5Acalpha-2,3-)Galbeta-1,4-Glc
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Substrates: also pyridylaminated
Products: -
Products: -
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CMP-N-acetylneuraminate + ovomucoid
CMP + ?
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Substrates: 8.4% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Products: -
Products: -
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CMP-N-acetylneuraminate + pyridylamine-type 2H
CMP + alpha2,6-sialylated blood group type 2H antigen
Substrates: 2% activity compared to pyridylaminyl-lacto-N-neotetraose
Products: -
Products: -
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CMP-N-acetylneuraminate + pyridylamino-lactose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosyl-pyridylaminoside
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Substrates: recombinant enzyme
Products: -
Products: -
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CMP-N-acetylneuraminate + pyridylamino-N-acetyllactosamine
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Substrates: -
Products: -
Products: -
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CMP-N-acetylneuraminate + pyridylaminyl-lacto-N-neotetraose
CMP + ?
Substrates: 100% activity
Products: -
Products: -
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CMP-N-acetylneuraminate + tumor necrosis factor receptor 1
CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
CMP-N-alpha-neuraminate + pyridylaminated ganglioside nLc4Cer
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Substrates: -
Products: -
Products: -
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CMP-NeuNAc + Galbeta(1->4)GIcNAc-R
CMP + NeuNAcalpha(2->6)Galbeta(l->4)GlcNAc-R
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Substrates: -
Products: -
Products: -
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cytidine 5'-monophosphate 3-(axial)-fluoro-N-acetylneuraminic acid + alpha-lactose
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Substrates: [15N]Phe-labeled ST6Gal-I with a 15fold excess of CMP-3FNeuAc
Products: -
Products: -
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cytidine 5'-monophosphate 4-O-(4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl) + alpha-N-acetyllactosamine
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Substrates: -
Products: -
Products: -
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cytidine-5'-monophospho-sialic acid + lactose
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Substrates: -
Products: -
Products: -
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cytidine-5'-monophospho-sialic acid + N-acetyllactosamine
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Substrates: -
Products: -
Products: -
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cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin
CMP + ?
Substrates: CMP-Neu9NSydCl
Products: -
Products: -
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cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + butyl beta-N-acetyllactosaminide
CMP + ?
Substrates: CMP-Neu9NSydCl
Products: -
Products: -
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cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin
CMP + ?
Substrates: CMP-Neu9Az
Products: -
Products: -
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cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + N-acetyllactosamin-butyl
CMP + ?
Substrates: CMP-Neu9Az
Products: -
Products: -
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Galbeta(1,4)GlcNAc-octyl + CMP-Neu5Ac
?
Substrates: membrane-bound and soluble protein, 100% relative activity
Products: -
Products: -
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GalNAcbeta(1,4)GlcNAc-octyl + CMP-Neu5Ac
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Substrates: membrane-bound and soluble protein, 312% and 346% relative activity, respectively
Products: -
Products: -
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N-acetyllactosamine 4-O-(4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl)
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Substrates: [15N]Phe-labeled ST6Gal-I with a 20fold excess of N-acetyllactosamine 4-O-(4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl)
Products: -
Products: -
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Neu5Acalpha-4-nitrophenyl + 4-methylumbelliferyl-beta-D-lactoside
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Substrates: alpha2,6-trans-sialidase activity of DELTA15Pd2,6ST
Products: -
Products: -
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CMP-9-O-acetyl-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
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Substrates: comparable or even higher transfer rates than with CMP-N-acetylneuraminate
Products: -
Products: -
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CMP-9-O-acetyl-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
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Substrates: comparable or even higher transfer rates than with CMP-N-acetylneuraminate
Products: -
Products: -
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CMP-N-acetyl-beta-neuraminate + asialo-alpha-1-antitrypsin
CMP + ?
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Substrates: -
Products: -
Products: -
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CMP-N-acetyl-beta-neuraminate + asialo-alpha-1-antitrypsin
CMP + ?
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Substrates: -
Products: -
Products: -
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CMP-N-acetyl-beta-neuraminate + asialo-alpha-1-antitrypsin
CMP + ?
Substrates: -
Products: -
Products: -
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CMP-N-acetyl-beta-neuraminate + asialo-alpha-1-antitrypsin
CMP + ?
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Substrates: -
Products: -
Products: -
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CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + ?
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Substrates: -
Products: -
Products: -
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CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + ?
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Substrates: -
Products: -
Products: -
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CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + ?
Substrates: -
Products: -
Products: -
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