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Information on EC 2.4.3.1 - beta-galactoside alpha-(2,6)-sialyltransferase
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2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferaseIUBMB Comments
The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
st6gal i, st6gal1, alpha 2,6-sialyltransferase, st6gal-1, st6gal, st6galnac2, alpha-2,6-sialyltransferase, st6gali, siat1, alpha 2,6-st, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha2,6-sialyltransferase 5
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6STase
alpha 2,6-sialyltransferase
alpha 2,6-ST
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alpha(2,6)-sialyltransferase
alpha(2,6)-ST
alpha-(2->6)-sialyltransferase
alpha-2,6-sialyltransferase
alpha2,6 sialyltransferase
alpha2,6-sialyltransferase
alpha2,6-ST
alpha2-6 sialyltransferase
antigens, CD75
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B-cell antigen CD75
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beta-galactoside alpha-2,6-sialyltransferase
beta-galactoside alpha2,6-sialyltransferase
beta-galactoside alpha2-6-sialyltransferase-1
CMP-acetylneuraminate-galactosylglycoprotein sialyltransferase
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CMP-acetylneuraminate-glycoprotein sialyltransferase
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CMP-acetylneuraminate-lactosylceramide-sialyltransferase
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CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine alpha-(2->6)-N-acetylneuraminyltransferase
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CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase
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CMP-N-acetylneuraminic acid-glycoprotein sialyltransferase
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CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase
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CMP-sialic acid:lactosylceramide sialyltransferase
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cytidine monophosphoacetylneuraminate-galactosylglycoprotein sialyltransferase
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cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase
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EC 2.4.99.1
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formerly
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EC 2.4.99.11
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formerly
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GM3-synthase
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HAC1268
lactosylceramide alpha-2,6-N-sialyltransferase
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sialotransferase
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sialyltransferase
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sialyltransferase, cytidine monophosphoacetylneuraminate-galactosylglycoprotein
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sialyltransferase, cytidine monophosphoacetylneuraminate-lactosylceramide
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ST6Gal
ST6Gal I
ST6Gal II
ST6Gal-1
ST6Gal-I
ST6Gal1
additional information
alpha2-6 sialyltransferase
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additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
additional information
ST6Gal I-IV subfamilies of the sialyltransferase family ST6Gal
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
mechanism
-
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
The terminal beta-D-galactosyl residue of the oligosaccharide of glycoproteins, as well as lactose, can act as acceptor
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CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Val220 participates in binding the common cytidine moiety in substrate CMP-NeuAc and inhibitor CDP
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
glycosyl group transfer
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)
The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.
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CAS REGISTRY NUMBER
COMMENTARY
55071-95-9
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9075-81-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
asialo-alpha1-acidglycoprotein + CMP-Neu5Ac
?
membrane-bound and soluble protein, 34% and 25% relative activity, respectively
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-
?
CMP-9-acetamido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
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-
-
-
?
CMP-9-amino-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-9-azido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-9-benzamido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-9-hexanoylamido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-9-O-acetyl-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
CMP + ?
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-
-
-
?
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R
CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
CMP-N-acetyl-beta-neuraminate + intercellular adhesion molecule-1
CMP + ?
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the enzyme can increase the stability of intercellular adhesion molecule-1 through sialylation
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-
?
CMP-N-acetyl-beta-neuraminate + methyl beta-D-N-acetyllactosaminide
CMP + methyl alpha-N-acetylneuraminyl-(2->6)-beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucopyranoside
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-
-
-
?
CMP-N-acetyl-beta-neuraminate + PrPSc
CMP + ?
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brain-, spleen- and N2a-cell-derived PrPSc is predominantly 2,6-sialylated
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-
?
CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
CMP + ?
CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methylamide
CMP + ?
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0.2% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
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?
CMP-N-acetylneuraminate + (Gal-3-O-Me)beta(1-3)(GlcNAc-6-O-Me)beta-O-Me
CMP + ?
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50% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
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?
CMP-N-acetylneuraminate + (Gal-3-O-Me)beta(1-3)GlcNAcbeta-O-Me
CMP + ?
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80% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
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?
CMP-N-acetylneuraminate + (Galbeta(1,4))2(GlcNAcbeta(1,2))2(Man)3(GlcNAc)2-Asn-Fmoc
?
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34.9 activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
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?
CMP-N-acetylneuraminate + (GalNAcbeta(1,4))2(GlcNAcbeta(1,2))2(Man)3(GlcNAc)2-Asn-Fmoc
?
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140 activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
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?
CMP-N-acetylneuraminate + 4-methylumbelliferyl beta-D-lactoside
?
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-
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?
CMP-N-acetylneuraminate + 4-nitrophenyl beta-D-galactopyranosyl-(1->3)-N-acetyl-beta-D-glucosaminide
CMP + 4-nitrophenyl N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactopyranosyl-(1->3)-N-acetyl-beta-D-glucosaminide
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2.5% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
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-
?
CMP-N-acetylneuraminate + 4-nitrophenyl beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
CMP + 4-nitrophenyl N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
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100% activity
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-
?
CMP-N-acetylneuraminate + 4-nitrophenyl N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
CMP + 4-nitrophenyl N-acetyl-alpha-neuraminyl-(2->6)-N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
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best acceptor with 371.5% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
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-
?
CMP-N-acetylneuraminate + 4-nitrophenyl-D-galactoside
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-(4-nitro)phenol
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-
-
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?
CMP-N-acetylneuraminate + 5-(5-dimethylaminonaphthalene-1-sulfonyl-2-(2-aminoethoxy))ethyl beta-lactose
CMP + ?
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-
-
?
CMP-N-acetylneuraminate + 5-(5-dimethylaminonaphthalene-1-sulfonyl-2-(2-aminoethoxy))ethyl beta-N-acetyllactosamine
CMP + 5-(5-dimethylaminonaphthalene-1-sulfonyl-2-(2-aminoethoxy)) ethyl beta-N-acetylneuraminic acid alpha-2,6-N-acetyllactosamine
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-
-
?
CMP-N-acetylneuraminate + alpha1-acid glycoprotein
CMP + ?
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20.6% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
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-
?
CMP-N-acetylneuraminate + asialo-agalacto-prothrombin
CMP + agalacto-prothrombin
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-
-
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?
CMP-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
CMP + ?
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12.3% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
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?
CMP-N-acetylneuraminate + asialo-apoceruloplasmin
CMP + apoceruloplasmin
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best substrate
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?
CMP-N-acetylneuraminate + asialo-chorionic gonadotropin
CMP + chorionic gonadotropin
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acceptor protein from human source
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?
CMP-N-acetylneuraminate + asialo-immunoglobulin G
CMP + immunoglobulin G
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?
CMP-N-acetylneuraminate + asialo-immunoglobulin M
CMP + immunoglobulin M
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?
CMP-N-acetylneuraminate + asialo-proteose peptone
CMP + proteose peptone
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?
CMP-N-acetylneuraminate + asialo-Tamm-Horsfall glycoprotein
CMP + Tamm-Horsfall glycoprotein
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-
-
-
?
CMP-N-acetylneuraminate + asialo-thyroglobulin glycopeptide
CMP + thyroglobulin glycopeptide
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-
-
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?
CMP-N-acetylneuraminate + asialoovomucoid
CMP + ?
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9.1% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
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?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosamine
Drosophila sp. (in: flies)
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36% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
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?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine-R
Drosophila sp. (in: flies)
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exhibits highest activity toward GalNAcbeta1,4GlcNAc carbohydrate structures at the non-reducing termini of oligosaccharides and glycoprotein glycans. Oligosaccharides are preferred over glycoproteins as acceptors, and no activity toward glycolipid acceptors is detected. Recombinant Drosophila SiaT expressed in cultured insect cells possesses in vivo and in vitro autosialylation activity toward beta-linked GalNAc termini of its own N-linked glycans
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-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,2-alpha-mannosyl-1,6-beta-mannosyl-1,4-N-acetylglucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,2-alpha-mannosyl-1,6-beta-mannosyl-1,4-N-acetylglucosamine
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,4-beta-D-galactosyl-1,4-beta-D-glucosyl-beta1-ceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,4-beta-D-galactosyl-1,4-beta-D-glucosyl-beta1-ceramide
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i.e. paragloboside
i.e. alpha-2,6-sialylparagloboside
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP-N-acetylneuraminate + formic acid (2R,3R,4S,5R,6R)-2-((2R,3R,4R,5R,6R)-3-acetylamino-5-hydroxy-2-methoxy-6-methylaminomethyl-tetrahydro-pyran-4-yloxy)-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl ester
CMP + ?
-
as active as Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + fucosyl-alpha-1,2-D-galactosyl-beta-1,4-D-glucose
?
-
-
-
-
?
CMP-N-acetylneuraminate + fucosyllactose
CMP + alpha-N-acetylneuraminyl-2,6-[alpha-L-fucopyranosyl-1,2]-beta-D-galactopyranosyl-1,4-D-glucopyranose
-
also pyridylaminated
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?
CMP-N-acetylneuraminate + Gal-beta-1,3-GlcNAc-beta-OMe
?
77% of the activity with lactose
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)(GlcNAc-6-O-Me)beta-O-Me
CMP + ?
-
80% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)-GlcNAcbeta(1-3)Galbeta(1-4)Glc
CMP + NeuNAcalpha(2-6)-Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc
Drosophila sp. (in: flies)
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30% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)GlcNAcbeta-O-Me
CMP + NeuAcalpha(2-6)Galbeta(1-3)GlcNAcbeta-O-Me
-
-
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc
CMP + alpha-N-acetylneuraminyl-(2-6)Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc
Drosophila sp. (in: flies)
-
79% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + Galbeta(1->3)GalNAc
CMP + NeuAcalpha(2->6)Galbeta(1->3)GalNAc
10% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + Galbeta(1->3)GlcNAc
CMP + NeuAcalpha(2->6)Galbeta(1->3)GlcNAc
2% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + Galbeta(1->4)GlcNAcbeta(1->2)Manalpha(1->6)[Galbeta(1->4)GlcNAcbeta(1>2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-pyridylamine
CMP + NeuAcalpha(2->6)Galbeta(1->4)GlcNAcbeta(1->2)Manalpha(1->6)[Galbeta(1->4)GlcNAcbeta(1>2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-pyridylamine
-
-
-
-
?
CMP-N-acetylneuraminate + Galbeta(1->4)GlcNAcbeta(1->3)Galbeta(1->4)Glcbeta(1<->1)ceramide
CMP + NeuAcalpha(2->6)Galbeta(1->4)GlcNAcbeta(1->3)Galbeta(1->4)Glcbeta(1<->1)ceramide
-
-
-
-
?
CMP-N-acetylneuraminate + Galbeta-4-nitrophenyl
?
-
26.4% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
-
-
?
CMP-N-acetylneuraminate + GalNAcbeta-4-nitrophenyl
?
-
120.4% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
-
-
?
CMP-N-acetylneuraminate + GalNAcbeta1,4-GlcNAc-R
CMP + alpha-N-acetylneuraminyl-2,6-GalNAcbeta1,4-GlcNAc-R
Drosophila sp. (in: flies)
-
-
190% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
?
CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
-
-
-
?
CMP-N-acetylneuraminate + lacto-N-neotetraose
CMP + ?
108% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucose
-
15.5% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + methanesulfonic acid (2R,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylmethyl ester
CMP + ?
-
90% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + methyl-alpha-D-galactopyranoside
?
2% of the activity with lactose
-
-
?
CMP-N-acetylneuraminate + methyl-beta-D-galactopyranoside
?
59% of the activity with lactose
-
-
?
CMP-N-acetylneuraminate + methyl-beta-D-galactopyranoside
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-methylgalactopyranoside
-
-
-
-
?
CMP-N-acetylneuraminate + N-((1R,3R,5R,6R,7S,8R,13R,15R,16R,17S)-6,7,17-trihydroxy-5-hydroxymethyl-15-methoxy-2,4,9,11,14-pentaoxa-tricyclo[11.3.1.03,8]heptadec-16-yl)-acetamide
CMP + ?
-
as active as Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-((1R,3R,5R,6R,7S,8R,14R,16R,17R,18R)-6,7,18-trihydroxy-5-hydroxymethyl-16-methoxy-11-oxo-2,4,9,15-tetraoxa-12-aza-tricyclo[12.3.1.03,8]octadec-17-yl)-acetamide
CMP + ?
-
110% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-((1R,3R,5R,6R,7S,8R,14R,16R,17R,18S)-6,7,18-trihydroxy-5-hydroxymethyl-16-methoxy-2,4,9,12,15-pentaoxa-tricyclo[12.3.1.03,8]octadec-17-yl)-acetamide
CMP + ?
-
130% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-acetyl-D-galactosamine
?
12% of the activity with lactose
-
-
?
CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-4-hydroxy-6-(methanesulfonylamino-methyl)-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
-
70% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-5-((2S,3R,4S,5R,6R)-4,5-dihydroxy-6-hydroxymethyl-3-methoxy-tetrahydro-pyran-2-yloxy)-6-formylaminomethyl-4-hydroxy-2-methoxy-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
-
as active as Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-6-(acetylamino-methyl)-4-hydroxy-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
-
60% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-6-aminomethyl-4-hydroxy-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
-
50% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + Neu5Acalpha-2,3-Galbeta-1,4-Glc
CMP + alpha-N-acetylneuraminyl-2,6-(Neu5Acalpha-2,3-)Galbeta-1,4-Glc
-
also pyridylaminated
-
-
?
CMP-N-acetylneuraminate + ovomucoid
CMP + ?
-
8.4% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + pyridylamine-type 2H
CMP + alpha2,6-sialylated blood group type 2H antigen
2% activity compared to pyridylaminyl-lacto-N-neotetraose
-
-
?
CMP-N-acetylneuraminate + pyridylamino-lactose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosyl-pyridylaminoside
-
recombinant enzyme
-
-
?
CMP-N-acetylneuraminate + pyridylaminyl-lacto-N-neotetraose
CMP + ?
100% activity
-
-
?
CMP-N-acetylneuraminate + tumor necrosis factor receptor 1
CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
CMP-NeuNAc + Galbeta(1->4)GIcNAc-R
CMP + NeuNAcalpha(2->6)Galbeta(l->4)GlcNAc-R
-
-
-
-
?
cytidine 5'-monophosphate 3-(axial)-fluoro-N-acetylneuraminic acid + alpha-lactose
?
-
[15N]Phe-labeled ST6Gal-I with a 15fold excess of CMP-3FNeuAc
-
-
?
cytidine 5'-monophosphate 4-O-(4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl) + alpha-N-acetyllactosamine
?
-
-
-
-
?
cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin
CMP + ?
CMP-Neu9NSydCl
-
-
?
cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + butyl beta-N-acetyllactosaminide
CMP + ?
CMP-Neu9NSydCl
-
-
?
cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin
CMP + ?
CMP-Neu9Az
-
-
?
cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + N-acetyllactosamin-butyl
CMP + ?
CMP-Neu9Az
-