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asialo-alpha1-acidglycoprotein + CMP-Neu5Ac
?
membrane-bound and soluble protein, 34% and 25% relative activity, respectively
-
-
?
CMP-9''-benzamido-Neu5Ac + lactose
?
-
-
-
-
?
CMP-9''-benzamido-Neu5Ac + N-acetyllactosamine
?
-
-
-
-
?
CMP-9''-phenylacetamido-Neu5Ac + lactose
?
-
-
-
-
?
CMP-9''-phenylacetamido-Neu5Ac + N-acetyllactosamine
?
-
-
-
-
?
CMP-9''-phenylhexanamido-Neu5Ac + lactose
?
-
-
-
-
?
CMP-9''-phenylhexanamido-Neu5Ac + N-acetyllactosamine
?
-
-
-
-
?
CMP-9''-phenylpropionamido-Neu5Ac + lactose
?
-
-
-
-
?
CMP-9''-phenylpropionamido-Neu5Ac + N-acetyllactosamine
?
-
-
-
-
?
CMP-9-acetamido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-9-amino-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-9-azido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-9-benzamido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-9-fluoresceinyl-N-acetylneuraminate + asialofetuin
?
-
-
-
?
CMP-9-hexanoylamido-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-9-O-acetyl-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
CMP-9-O-acetyl-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + alpha-1-antitrypsin
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + asialo-alpha-1-antitrypsin
CMP + ?
CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + ?
CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + fetuin
-
-
-
?
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R
CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
CMP-N-acetyl-beta-neuraminate + desialylated fetuin
CMP + ?
-
-
-
?
CMP-N-acetyl-beta-neuraminate + human butyrylcholinesterase
CMP + ?
CMP-N-acetyl-beta-neuraminate + integrin-beta1
CMP + ?
-
-
-
?
CMP-N-acetyl-beta-neuraminate + intercellular adhesion molecule-1
CMP + ?
-
the enzyme can increase the stability of intercellular adhesion molecule-1 through sialylation
-
-
?
CMP-N-acetyl-beta-neuraminate + methyl beta-D-N-acetyllactosaminide
CMP + methyl alpha-N-acetylneuraminyl-(2->6)-beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucopyranoside
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + N-acetyl-D-lactosamine
?
CMP-N-acetyl-beta-neuraminate + N-acetyllactosamin-butyl
CMP + ?
-
-
-
?
CMP-N-acetyl-beta-neuraminate + PrPc
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + PrPSc
CMP + ?
-
brain-, spleen- and N2a-cell-derived PrPSc is predominantly 2,6-sialylated
-
-
?
CMP-N-acetyl-beta-neuraminate + recombinant alpha-1-antitrypsin
CMP + ?
CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
CMP + ?
CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methylamide
CMP + ?
-
0.2% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + (Gal-3-O-Me)beta(1-3)(GlcNAc-6-O-Me)beta-O-Me
CMP + ?
-
50% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + (Gal-3-O-Me)beta(1-3)GlcNAcbeta-O-Me
CMP + ?
-
80% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + (Galbeta(1,4))2(GlcNAcbeta(1,2))2(Man)3(GlcNAc)2-Asn-Fmoc
?
-
34.9 activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
-
-
?
CMP-N-acetylneuraminate + (GalNAcbeta(1,4))2(GlcNAcbeta(1,2))2(Man)3(GlcNAc)2-Asn-Fmoc
?
-
140 activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
-
-
?
CMP-N-acetylneuraminate + 4-methylumbelliferyl beta-D-lactoside
?
-
-
-
-
?
CMP-N-acetylneuraminate + 4-nitrophenyl beta-D-galactopyranosyl-(1->3)-N-acetyl-beta-D-glucosaminide
CMP + 4-nitrophenyl N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactopyranosyl-(1->3)-N-acetyl-beta-D-glucosaminide
-
2.5% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
-
-
?
CMP-N-acetylneuraminate + 4-nitrophenyl beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
CMP + 4-nitrophenyl N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
-
100% activity
-
-
?
CMP-N-acetylneuraminate + 4-nitrophenyl N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
CMP + 4-nitrophenyl N-acetyl-alpha-neuraminyl-(2->6)-N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide
-
best acceptor with 371.5% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
-
-
?
CMP-N-acetylneuraminate + 4-nitrophenyl-D-galactoside
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-(4-nitro)phenol
-
-
-
-
?
CMP-N-acetylneuraminate + 5-(5-dimethylaminonaphthalene-1-sulfonyl-2-(2-aminoethoxy))ethyl beta-lactose
CMP + ?
-
-
-
?
CMP-N-acetylneuraminate + 5-(5-dimethylaminonaphthalene-1-sulfonyl-2-(2-aminoethoxy))ethyl beta-N-acetyllactosamine
CMP + 5-(5-dimethylaminonaphthalene-1-sulfonyl-2-(2-aminoethoxy)) ethyl beta-N-acetylneuraminic acid alpha-2,6-N-acetyllactosamine
-
-
-
?
CMP-N-acetylneuraminate + 6'-sialyl-N-acetyl-D-lactosamine
?
-
-
-
?
CMP-N-acetylneuraminate + AA-labeled 6'-sialyllactose
?
CMP-N-acetylneuraminate + AA-labeled G2 glycan
?
CMP-N-acetylneuraminate + alpha1-acid glycoprotein
CMP + ?
-
20.6% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + asialo-agalacto-prothrombin
CMP + agalacto-prothrombin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
CMP + ?
-
12.3% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
CMP + alpha1-acid glycoprotein
CMP-N-acetylneuraminate + asialo-apoceruloplasmin
CMP + apoceruloplasmin
-
best substrate
-
-
?
CMP-N-acetylneuraminate + asialo-ceruloplasmin
CMP + ceruloplasmin
CMP-N-acetylneuraminate + asialo-chorionic gonadotropin
CMP + chorionic gonadotropin
-
acceptor protein from human source
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
CMP-N-acetylneuraminate + asialo-fibrinogen
CMP + fibrinogen
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-immunoglobulin G
CMP + immunoglobulin G
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-immunoglobulin M
CMP + immunoglobulin M
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
CMP-N-acetylneuraminate + asialo-proteose peptone
CMP + proteose peptone
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-prothrombin
CMP + prothrombin
CMP-N-acetylneuraminate + asialo-Tamm-Horsfall glycoprotein
CMP + Tamm-Horsfall glycoprotein
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-thyroglobulin
CMP + thyroglobulin
CMP-N-acetylneuraminate + asialo-thyroglobulin glycopeptide
CMP + thyroglobulin glycopeptide
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-transferrin
CMP + transferrin
CMP-N-acetylneuraminate + asialofetuin
?
CMP-N-acetylneuraminate + asialoovomucoid
CMP + ?
-
9.1% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosamine
Drosophila sp. (in: flies)
-
36% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine-R
Drosophila sp. (in: flies)
-
exhibits highest activity toward GalNAcbeta1,4GlcNAc carbohydrate structures at the non-reducing termini of oligosaccharides and glycoprotein glycans. Oligosaccharides are preferred over glycoproteins as acceptors, and no activity toward glycolipid acceptors is detected. Recombinant Drosophila SiaT expressed in cultured insect cells possesses in vivo and in vitro autosialylation activity toward beta-linked GalNAc termini of its own N-linked glycans
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,2-alpha-mannosyl-1,6-beta-mannosyl-1,4-N-acetylglucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,2-alpha-mannosyl-1,6-beta-mannosyl-1,4-N-acetylglucosamine
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,4-beta-D-galactosyl-1,4-beta-D-glucosyl-beta1-ceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,4-beta-D-galactosyl-1,4-beta-D-glucosyl-beta1-ceramide
-
i.e. paragloboside
i.e. alpha-2,6-sialylparagloboside
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP-N-acetylneuraminate + fetuin
?
CMP-N-acetylneuraminate + formic acid (2R,3R,4S,5R,6R)-2-((2R,3R,4R,5R,6R)-3-acetylamino-5-hydroxy-2-methoxy-6-methylaminomethyl-tetrahydro-pyran-4-yloxy)-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl ester
CMP + ?
-
as active as Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + fucosyl-alpha-1,2-D-galactosyl-beta-1,4-D-glucose
?
-
-
-
-
?
CMP-N-acetylneuraminate + fucosyllactose
CMP + alpha-N-acetylneuraminyl-2,6-[alpha-L-fucopyranosyl-1,2]-beta-D-galactopyranosyl-1,4-D-glucopyranose
-
also pyridylaminated
-
?
CMP-N-acetylneuraminate + Gal-beta-1,3-GlcNAc-beta-OMe
?
77% of the activity with lactose
-
-
?
CMP-N-acetylneuraminate + galactin-1
CMP + ?
-
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)(GlcNAc-6-O-Me)beta-O-Me
CMP + ?
-
80% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)-GlcNAcbeta(1-3)Galbeta(1-4)Glc
CMP + NeuNAcalpha(2-6)-Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc
Drosophila sp. (in: flies)
-
30% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-3)GlcNAcbeta-O-Me
CMP + NeuAcalpha(2-6)Galbeta(1-3)GlcNAcbeta-O-Me
-
-
-
-
?
CMP-N-acetylneuraminate + Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc
CMP + alpha-N-acetylneuraminyl-(2-6)Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc
Drosophila sp. (in: flies)
-
79% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + Galbeta(1->3)GalNAc
CMP + NeuAcalpha(2->6)Galbeta(1->3)GalNAc
10% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + Galbeta(1->3)GlcNAc
CMP + NeuAcalpha(2->6)Galbeta(1->3)GlcNAc
2% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + Galbeta(1->4)GlcNAcbeta(1->2)Manalpha(1->6)[Galbeta(1->4)GlcNAcbeta(1>2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-pyridylamine
CMP + NeuAcalpha(2->6)Galbeta(1->4)GlcNAcbeta(1->2)Manalpha(1->6)[Galbeta(1->4)GlcNAcbeta(1>2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-pyridylamine
-
-
-
-
?
CMP-N-acetylneuraminate + Galbeta(1->4)GlcNAcbeta(1->3)Galbeta(1->4)Glcbeta(1<->1)ceramide
CMP + NeuAcalpha(2->6)Galbeta(1->4)GlcNAcbeta(1->3)Galbeta(1->4)Glcbeta(1<->1)ceramide
-
-
-
-
?
CMP-N-acetylneuraminate + Galbeta-4-nitrophenyl
?
-
26.4% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
-
-
?
CMP-N-acetylneuraminate + GalNAcbeta-4-nitrophenyl
?
-
120.4% activity compared to Galbeta(1,4)-GlcNAcbeta-4-nitrophenyl
-
-
?
CMP-N-acetylneuraminate + GalNAcbeta1,4-GlcNAc-R
CMP + alpha-N-acetylneuraminyl-2,6-GalNAcbeta1,4-GlcNAc-R
Drosophila sp. (in: flies)
-
-
190% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
?
CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
-
-
-
?
CMP-N-acetylneuraminate + lacto-N-neotetraose
?
CMP-N-acetylneuraminate + lacto-N-neotetraose
CMP + ?
108% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + lacto-N-tetraose
CMP + ?
CMP-N-acetylneuraminate + lactosamine
?
-
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
CMP-N-acetylneuraminate + lactose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucose
-
15.5% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + methanesulfonic acid (2R,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylmethyl ester
CMP + ?
-
90% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + methyl-alpha-D-galactopyranoside
?
2% of the activity with lactose
-
-
?
CMP-N-acetylneuraminate + methyl-beta-D-galactopyranoside
?
59% of the activity with lactose
-
-
?
CMP-N-acetylneuraminate + methyl-beta-D-galactopyranoside
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-methylgalactopyranoside
-
-
-
-
?
CMP-N-acetylneuraminate + N-((1R,3R,5R,6R,7S,8R,13R,15R,16R,17S)-6,7,17-trihydroxy-5-hydroxymethyl-15-methoxy-2,4,9,11,14-pentaoxa-tricyclo[11.3.1.03,8]heptadec-16-yl)-acetamide
CMP + ?
-
as active as Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-((1R,3R,5R,6R,7S,8R,14R,16R,17R,18R)-6,7,18-trihydroxy-5-hydroxymethyl-16-methoxy-11-oxo-2,4,9,15-tetraoxa-12-aza-tricyclo[12.3.1.03,8]octadec-17-yl)-acetamide
CMP + ?
-
110% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-((1R,3R,5R,6R,7S,8R,14R,16R,17R,18S)-6,7,18-trihydroxy-5-hydroxymethyl-16-methoxy-2,4,9,12,15-pentaoxa-tricyclo[12.3.1.03,8]octadec-17-yl)-acetamide
CMP + ?
-
130% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-acetyl-D-galactosamine
?
12% of the activity with lactose
-
-
?
CMP-N-acetylneuraminate + N-acetyllactosamine
?
CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-4-hydroxy-6-(methanesulfonylamino-methyl)-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
-
70% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-5-((2S,3R,4S,5R,6R)-4,5-dihydroxy-6-hydroxymethyl-3-methoxy-tetrahydro-pyran-2-yloxy)-6-formylaminomethyl-4-hydroxy-2-methoxy-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
-
as active as Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-6-(acetylamino-methyl)-4-hydroxy-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
-
60% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + N-[(2R,3R,4R,5S,6R)-6-aminomethyl-4-hydroxy-2-methoxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide
CMP + ?
-
50% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + Neu5Acalpha-2,3-Galbeta-1,4-Glc
CMP + alpha-N-acetylneuraminyl-2,6-(Neu5Acalpha-2,3-)Galbeta-1,4-Glc
-
also pyridylaminated
-
-
?
CMP-N-acetylneuraminate + ovomucoid
CMP + ?
-
8.4% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + pyridylamine-type 2H
CMP + alpha2,6-sialylated blood group type 2H antigen
2% activity compared to pyridylaminyl-lacto-N-neotetraose
-
-
?
CMP-N-acetylneuraminate + pyridylamino-lactose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosyl-pyridylaminoside
-
recombinant enzyme
-
-
?
CMP-N-acetylneuraminate + pyridylamino-N-acetyllactosamine
?
-
-
-
-
?
CMP-N-acetylneuraminate + pyridylaminyl-lacto-N-neotetraose
CMP + ?
100% activity
-
-
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
CMP-N-acetylneuraminate + tumor necrosis factor receptor 1
CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
CMP-N-alpha-neuraminate + ganglioside nLc4Cer
?
-
-
-
-
?
CMP-N-alpha-neuraminate + ganglioside nLc6Cer
?
-
-
-
-
?
CMP-N-alpha-neuraminate + pyridylaminated ganglioside nLc4Cer
?
-
-
-
-
?
CMP-N-aminoacetylneuraminate + asialo-alpha1-acid glycoprotein
?
CMP-N-formylneuraminate + asialo-alpha1-acid glycoprotein
?
CMP-N-glycolylneuraminate + asialo-alpha1-acid glycoprotein
?
CMP-Neu5Ac + lactose
CMP + Neu5Acalpha(2-6)Lac
CMP-Neu5Ac + methyl-beta-D-galactopyranoside
CMP + Neu5Acalpha(2-6)Gal-alpha-methyl
CMP-Neu5Ac + N-acetyllactosamine
CMP + Neu5Acalpha(2-6)LacNAc
CMP-NeuNAc + Galbeta(1-3)GlcNAc
?
-
-
-
-
?
CMP-NeuNAc + Galbeta(1->4)GIcNAc-R
CMP + NeuNAcalpha(2->6)Galbeta(l->4)GlcNAc-R
-
-
-
-
?
CMP-NeuNAc + Galbeta(l->6)GlcNAc
?
-
-
-
-
?
CMP-NeuNAc + lactose
?
-
-
-
-
?
CMP-NeuNAc + N-acetyllactosamine
?
-
-
-
-
?
cytidine 5'-monophosphate 3-(axial)-fluoro-N-acetylneuraminic acid + alpha-lactose
?
-
[15N]Phe-labeled ST6Gal-I with a 15fold excess of CMP-3FNeuAc
-
-
?
cytidine 5'-monophosphate 4-O-(4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl) + alpha-N-acetyllactosamine
?
-
-
-
-
?
cytidine-5'-monophospho-sialic acid + lactose
?
-
-
-
-
?
cytidine-5'-monophospho-sialic acid + N-acetyllactosamine
?
-
-
-
-
?
cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin
CMP + ?
CMP-Neu9NSydCl
-
-
?
cytidine-5'-yl-5-(acetamido)-9-(3-[4-chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + butyl beta-N-acetyllactosaminide
CMP + ?
CMP-Neu9NSydCl
-
-
?
cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + asialofetuin
CMP + ?
CMP-Neu9Az
-
-
?
cytidine-5'-yl-5-(acetamido)-9-azido-3,5,9-trideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate + N-acetyllactosamin-butyl
CMP + ?
CMP-Neu9Az
-
-
?
Galbeta(1,4)GlcNAc-octyl + CMP-Neu5Ac
?
membrane-bound and soluble protein, 100% relative activity
-
-
?
GalNAcbeta(1,4)GlcNAc-octyl + CMP-Neu5Ac
?
membrane-bound and soluble protein, 312% and 346% relative activity, respectively
-
-
?
N-acetyllactosamine 4-O-(4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl)
?
-
[15N]Phe-labeled ST6Gal-I with a 20fold excess of N-acetyllactosamine 4-O-(4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl)
-
-
?
Neu5Acalpha-4-nitrophenyl + 4-methylumbelliferyl-beta-D-lactoside
?
-
alpha2,6-trans-sialidase activity of DELTA15Pd2,6ST
-
-
?
additional information
?
-
CMP-9-O-acetyl-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
comparable or even higher transfer rates than with CMP-N-acetylneuraminate
-
-
?
CMP-9-O-acetyl-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
comparable or even higher transfer rates than with CMP-N-acetylneuraminate
-
-
?
CMP-N-acetyl-beta-neuraminate + asialo-alpha-1-antitrypsin
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + asialo-alpha-1-antitrypsin
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + asialo-alpha-1-antitrypsin
CMP + ?
-
-
-
?
CMP-N-acetyl-beta-neuraminate + asialo-alpha-1-antitrypsin
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + ?
-
-
-
?
CMP-N-acetyl-beta-neuraminate + asialofetuin
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R
CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R
CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
-
-
-
?
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R
CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R
CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
-
-
-
?
CMP-N-acetyl-beta-neuraminate + human butyrylcholinesterase
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + human butyrylcholinesterase
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + human butyrylcholinesterase
CMP + ?
-
-
-
?
CMP-N-acetyl-beta-neuraminate + human butyrylcholinesterase
CMP + ?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + N-acetyl-D-lactosamine
?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + N-acetyl-D-lactosamine
?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + N-acetyl-D-lactosamine
?
-
-
-
?
CMP-N-acetyl-beta-neuraminate + N-acetyl-D-lactosamine
?
-
-
-
-
?
CMP-N-acetyl-beta-neuraminate + recombinant alpha-1-antitrypsin
CMP + ?
-
-
-
?
CMP-N-acetyl-beta-neuraminate + recombinant alpha-1-antitrypsin
CMP + ?
-
-
-
-
?
CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
CMP + ?
-
-
-
-
?
CMP-N-acetylneuraminate + (2S,3S,4R,5R,6R)-5-acetylamino-4-hydroxy-6-methoxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
CMP + ?
-
160% of the activity with Galbeta(1-3)GlcNAcbeta-O-Me
-
-
?
CMP-N-acetylneuraminate + AA-labeled 6'-sialyllactose
?
-
-
-
?
CMP-N-acetylneuraminate + AA-labeled 6'-sialyllactose
?
-
-
-
?
CMP-N-acetylneuraminate + AA-labeled 6'-sialyllactose
?
-
-
-
?
CMP-N-acetylneuraminate + AA-labeled 6'-sialyllactose
?
-
-
-
?
CMP-N-acetylneuraminate + AA-labeled G2 glycan
?
-
-
-
?
CMP-N-acetylneuraminate + AA-labeled G2 glycan
?
-
-
-
?
CMP-N-acetylneuraminate + AA-labeled G2 glycan
?
-
-
-
?
CMP-N-acetylneuraminate + AA-labeled G2 glycan
?
-
-
-
?
CMP-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
CMP + alpha1-acid glycoprotein
-
176% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
CMP + alpha1-acid glycoprotein
-
-
-
?
CMP-N-acetylneuraminate + asialo-ceruloplasmin
CMP + ceruloplasmin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-ceruloplasmin
CMP + ceruloplasmin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
best substrate
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
106% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
21% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
recombinant isoform STcys is somewhat more active then the recombinant isoform STtyr
-
-
?
CMP-N-acetylneuraminate + asialo-fetuin
CMP + fetuin
-
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
best substrate
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
CMP-N-acetylneuraminate can be replaced with comparable or even higher transfer rates by CMP-N-glycolylneuraminate, CMP-9-O-acetyl-N-acetylneuraminate
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
i.e. asialo-alpha1 acid glycoprotein
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
best substrate
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
i.e. asialo-alpha1 acid glycoprotein
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
i.e. asialo-alpha1 acid glycoprotein
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
i.e. asialo-alpha1 acid glycoprotein
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
about half as effective as asialofetuin
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
CMP-N-acetylneuraminate can be replaced with comparable or even higher transfer rates by CMP-N-glycolylneuraminate, CMP-9-O-acetyl-N-acetylneuraminate
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
i.e. asialo-alpha1 acid glycoprotein
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
i.e. asialo-alpha1 acid glycoprotein
-
-
?
CMP-N-acetylneuraminate + asialo-orosomucoid
CMP + orosomucoid
-
i.e. asialo-alpha1 acid glycoprotein
-
-
?
CMP-N-acetylneuraminate + asialo-prothrombin
CMP + prothrombin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-prothrombin
CMP + prothrombin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-prothrombin
CMP + prothrombin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-thyroglobulin
CMP + thyroglobulin
-
low activity
-
-
?
CMP-N-acetylneuraminate + asialo-thyroglobulin
CMP + thyroglobulin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-transferrin
CMP + transferrin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-transferrin
CMP + transferrin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-transferrin
CMP + transferrin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-transferrin
CMP + transferrin
-
-
-
-
?
CMP-N-acetylneuraminate + asialo-transferrin
CMP + transferrin
-
poor substrate
-
-
?
CMP-N-acetylneuraminate + asialofetuin
?
-
-
-
-
?
CMP-N-acetylneuraminate + asialofetuin
?
-
-
-
-
?
CMP-N-acetylneuraminate + asialofetuin
?
-
-
-
?
CMP-N-acetylneuraminate + asialofetuin
?
-
-
-
?
CMP-N-acetylneuraminate + asialofetuin
?
-
-
-
?
CMP-N-acetylneuraminate + asialofetuin
?
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
-
106% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
-
129% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
i.e. lactosylceramide
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
best substrate
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
i.e. N-acetyllactosamine
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
i.e. N-acetyllactosamine
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
most active disaccharide substrate
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
i.e. N-acetyllactosamine
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
most active disaccharide substrate
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
Drosophila sp. (in: flies)
-
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
highest activity
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
highest activity
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
poor substrate
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
i.e. N-acetyllactosamine
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
i.e. N-acetyllactosamine
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
most active disaccharide substrate
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
100% activity
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
i.e. N-acetyllactosamine
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
i.e. N-acetyllactosamine
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
i.e. N-acetyllactosamine
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
i.e. N-acetyllactosamine
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
i.e. N-acetyllactosamine
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
R: glycoprotein or glycopeptide
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
R: glycoprotein or glycopeptide
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
transfers sialic acid to terminal positions on N-linked glycans
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
transfers sialic acid to the terminal galactose residue of asialo-gyloproteins and peptides
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
strictly specific for CMP-N-acetylneuraminate, forms only alpha2,6-linkages
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
high molecular weight substrates are more efficient acceptors than low molecular weight substrates
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
high molecular weight substrates are more efficient acceptors than low molecular weight substrates
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
one of a group of glycosyltransferases which act to assemble the carbohydrate units of thyroglobulin
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
final step in synthesis of serum-type glycoproteins
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
high molecular weight substrates are more efficient acceptors than low molecular weight substrates
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
final step in synthesis of serum-type glycoproteins
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
transfers sialic acid to terminal positions on N-linked glycans
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
substrate specificity for several synthetic trisaccharides
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
high molecular weight substrates are more efficient acceptors than low molecular weight substrates
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
high molecular weight substrates are more efficient acceptors than low molecular weight substrates
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
CMP-N-acetylneuraminate analogues can serve as donor substrates, i.e. formyl-, trifluoroacetyl-, benzyloxycarbonyl-, and amino acetyl-N-neuraminates
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
final step in synthesis of serum-type glycoproteins
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
strictly specific for CMP-N-acetylneuraminate, forms only alpha2,6-linkages
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
strictly specific for CMP-N-acetylneuraminate, forms only alpha2,6-linkages
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
strictly specific for CMP-N-acetylneuraminate, forms only alpha2,6-linkages
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
strictly specific for CMP-N-acetylneuraminate, forms only alpha2,6-linkages
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
R: glycoprotein or glycopeptide
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
R: glycoprotein or glycopeptide
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
transfers sialic acid to terminal positions on N-linked glycans
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
transfers sialic acid to terminal positions on N-linked glycans
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
transfers sialic acid to terminal positions on N-linked glycans
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
transfers sialic acid to terminal positions on N-linked glycans
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
CMP-N-acetylneuraminate analogues can serve as donor substrates, i.e. the 5''-amino-, the 5''-N-pentanoylamino-, the 5''-glycylamino-, and the 5''-ethoxycarbonylamino derivative and diammonium (cytidin-5'-yl) [(3-deoxy-D-glycero-beta-D-galacto-2-nonulpyranosyl)onate] phosphate
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
the non-reducing terminal galactosyl residue is essential for activity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
substrate specificity for several synthetic trisaccharides
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
synthetic disaccharides
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
CMP-N-acetylneuraminate analogues can serve as donor substrates, i.e. formyl-, trifluoroacetyl-, benzyloxycarbonyl-, and amino acetyl-N-neuraminates
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
donor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
donor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
regulation of enzyme expression
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
R: glycoprotein or glycopeptide
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
acceptor substrate specificity
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
sialic acid is linked to C-6 of the galactose residue
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
synthetic disaccharides
-
?
CMP-N-acetylneuraminate + fetuin
?
-
-
-
-
?
CMP-N-acetylneuraminate + fetuin
?
-
glycopeptides
-
-
?
CMP-N-acetylneuraminate + fetuin
?
-
no activity
-
-
?
CMP-N-acetylneuraminate + fetuin
?
-
about 30% as effective as asialofetuin
-
-
?
CMP-N-acetylneuraminate + lacto-N-neotetraose
?
-
-
-
-
?
CMP-N-acetylneuraminate + lacto-N-neotetraose
?
-
-
-
-
?
CMP-N-acetylneuraminate + lacto-N-tetraose
CMP + ?
-
36.8% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + lacto-N-tetraose
CMP + ?
35% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
no activity
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
poor substrate
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
14% activity compared to beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
Asp232 might act as a catalytic base for deprotonation of the acceptor substrate, and His405 might act as a catalytic acid for protonation of the donor substrate
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
-
-
-
?
CMP-N-acetylneuraminate + lactose
CMP + 6'-sialyllactose
-
poor substrate
-
?
CMP-N-acetylneuraminate + N-acetyllactosamine
?
99% of the activity with lactose
-
-
?
CMP-N-acetylneuraminate + N-acetyllactosamine
?
-
-
-
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
poor substrates, no activity with ovine acceptor
-
-
?
CMP-N-acetylneuraminate + submaxillary asialo-mucin
CMP + submaxillary mucin
-
-
-
-
?
CMP-N-acetylneuraminate + tumor necrosis factor receptor 1
CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
-
-
-
?
CMP-N-acetylneuraminate + tumor necrosis factor receptor 1
CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
-
-
-
?
CMP-N-aminoacetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-N-aminoacetylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-N-formylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-N-formylneuraminate + asialo-alpha1-acid glycoprotein
?
-
-
-
-
?
CMP-N-glycolylneuraminate + asialo-alpha1-acid glycoprotein
?
-
comparable or even higher transfer rates than with CMP-N-acetylneuraminate
-
-
?
CMP-N-glycolylneuraminate + asialo-alpha1-acid glycoprotein
?
-
comparable or even higher transfer rates than with CMP-N-acetylneuraminate
-
-
?
CMP-Neu5Ac + lactose
CMP + Neu5Acalpha(2-6)Lac
-
alpha2,6-sialyltransferase activity
-
-
?
CMP-Neu5Ac + lactose
CMP + Neu5Acalpha(2-6)Lac
-
alpha2,6-sialyltransferase activity
-
-
?
CMP-Neu5Ac + methyl-beta-D-galactopyranoside
CMP + Neu5Acalpha(2-6)Gal-alpha-methyl
-
alpha2,6-sialyltransferase activity
-
-
?
CMP-Neu5Ac + methyl-beta-D-galactopyranoside
CMP + Neu5Acalpha(2-6)Gal-alpha-methyl
-
alpha2,6-sialyltransferase activity
-
-
?
CMP-Neu5Ac + N-acetyllactosamine
CMP + Neu5Acalpha(2-6)LacNAc
-
alpha2,6-sialyltransferase activity
-
-
?
CMP-Neu5Ac + N-acetyllactosamine
CMP + Neu5Acalpha(2-6)LacNAc
-
alpha2,6-sialyltransferase activity
-
-
?
additional information
?
-
-
no activity towards Glcalpha-4-nitrophenyl, Galalpha-4-nitrophenyl, GalNAcalpha-4-nitrophenyl, Galbeta(1,3)-GalNAcbeta-4-nitrophenyl and GalNAcbeta(1,3)-GlcNAcbeta-4-nitrophenyl
-
-
?
additional information
?
-
-
no activity with galactosylhydroxylysine and its derivatives, or galactose-containing oligosaccharides linked to Ser/Thr-glycopeptide of earthworm cuticle collagen
-
-
?
additional information
?
-
-
no transfer to terminal N-acetyl-D-galactosamine
-
-
?
additional information
?
-
-
no activity with beta-methyl-L-arabinopyranoside
-
-
?
additional information
?
-
-
no activity with submaxillary asialo-mucin
-
-
?
additional information
?
-
-
galactose-free glycopeptides are poor substrates
-
-
?
additional information
?
-
-
no activity with antifreeze glycoprotein
-
-
?
additional information
?
-
-
poor substrates are the beta-1,3- or beta-1,6-derivatives of beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
?
additional information
?
-
-
no activity with galactose, lactose and N-acetyllactose
-
-
?
additional information
?
-
-
no activity with ovine submaxillary asialo-mucin
-
-
?
additional information
?
-
-
no activity with ovine submaxillary asialo-mucin
-
-
?
additional information
?
-
the enzyme uses the LacdiNAc structure (GalNAcbeta1,4GlcNAc) as a better acceptor substrate than the type II (Galbeta1-4GlcNAc) disaccharide. The enzyme's efficiency is improved when the acceptor substrate is provided as a free oligosaccharide rather than as a protein-bound oligosaccharide. No activity with alpha1-acidglycoprotein and Galbeta13GlcNAc-octyl
-
-
?
additional information
?
-
-
the enzyme uses the LacdiNAc structure (GalNAcbeta1,4GlcNAc) as a better acceptor substrate than the type II (Galbeta1-4GlcNAc) disaccharide. The enzyme's efficiency is improved when the acceptor substrate is provided as a free oligosaccharide rather than as a protein-bound oligosaccharide. No activity with alpha1-acidglycoprotein and Galbeta13GlcNAc-octyl
-
-
?
additional information
?
-
-
the enzyme prefers to attach sialic acid to the Gal on the Manalpha(1->3)-arm of the core. Galbeta(l->4)GlcNAc and glycopeptides and glycoproteins with Galbeta(l->4)GlcNAc termini are the only good acceptors. Galbeta(l->3)GalNAc-terminal glycoproteins are not acceptors for enzyme
-
-
-
additional information
?
-
-
no activity with submaxillary asialo-mucin
-
-
?
additional information
?
-
no activity with Gal-beta1,3-GlcNAc, T-antigen Gal-beta1,3-GalNAc-alpha, and NeuAc-alpha2,3-Gal-beta1,4-Glc
-
-
?
additional information
?
-
-
no activity with Gal-beta1,3-GlcNAc, T-antigen Gal-beta1,3-GalNAc-alpha, and NeuAc-alpha2,3-Gal-beta1,4-Glc
-
-
?
additional information
?
-
no activity with Gal-beta1,3-GlcNAc, T-antigen Gal-beta1,3-GalNAc-alpha, and NeuAc-alpha2,3-Gal-beta1,4-Glc
-
-
?
additional information
?
-
-
no activity with Gal-beta1,3-GlcNAc, T-antigen Gal-beta1,3-GalNAc-alpha, and NeuAc-alpha2,3-Gal-beta1,4-Glc
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
the catalytic domain can proceed with sialic acid transfer with increased efficiency until 80 amino acid are deleted
-
-
?
additional information
?
-
-
no activity with N-acetyl-D-galactosamine or N-acetyl-D-glucosamine, and asialo-agalacto-fetuin, and galactose
-
-
?
additional information
?
-
-
no activity with Lc4Cer and Lc3Cer
-
-
?
additional information
?
-
radiation exposure is found to increase the sialylation of glycoproteins such as integrin beta1 by inducing the expression of ST6Gal I, and increased protein sialylation contributed to cellular radiation resistance
-
-
?
additional information
?
-
-
soluble ST6Gal I produced by BACE1 plays, at least in part, a role in the sialylation of soluble glycoproteins
-
-
?
additional information
?
-
-
the enzyme transfers Neu5Ac of CMP-Neu5Ac to the 6-hydroxyl group on internal GalNAc on O-glycans with strict specificities towards the O-glycan GalNAcalpha- (Tnantigen), Galbeta1-3GalNAcalpha- (T-antigen) and Neu5Acalpha2-3Galbeta1-3GalNAcalpha- (sialyl T-antigen) structures. hST6GalNAc-I shows activities towards O-linked oligosaccharides attached to peptides of glycoproteins and weak activities towards synthetic non-amino acid aglycons of O-glycans hST6GalNAc-I. hST6GalNAc-I shows strong activities with core 2 glycans (Galbeta1-3GalNAcbeta[GlcNAcbeta1-6]GalNAc). Core 2 O-glycan structures lacking the terminal galactose such as core 6 (GlcNAcbeta1-6GalNAcalpha-) or substituted with other monosaccharides such as core 4 (GlcNAcbeta1-3[GlcNAcbeta1-6]GalNAcalpha-) do not give any signal indicating that hST6GalNAc-I possibly also sialylated the terminal galactose of core 2 glycans. Relative specificities for the acceptors, Galbeta1-3GalNAcalphaOpNP (23%), Galbeta1-3[GlcNAcbeta1-6]GalNAcOalphapNP (12%), Galbeta1-3GalNAcOalphaThr (100%) and Galbeta1-3[GlcNAcbeta1-6]Galalpha2-6GalNAcOalphaThr (alpha2-6sialyl Tn-antigen). Relative specificities of the acceptors, Galbeta1-3GalNAcalphaOpNP (0%), Galbeta1-3[GlcNAcbeta1-6]GalNAcOalphapNP (0%), Galbeta1-3GalNAcOalphaThr (100%) and Galbeta1-3[GlcNAcbeta1-6]GalNAcalphaThr (19%) are found
-
-
?
additional information
?
-
the enzyme cannot transfer a N-acetylneuraminate residue to pyridylaminyl-LNFP I, a type 1 chain derivative of the blood group H antigen
-
-
?
additional information
?
-
-
the enzyme cannot transfer a N-acetylneuraminate residue to pyridylaminyl-LNFP I, a type 1 chain derivative of the blood group H antigen
-
-
?
additional information
?
-
the enzyme catalyzes alpha-2,6-sialylation of galactose on glycoproteins
-
-
?
additional information
?
-
-
the enzyme catalyzes alpha-2,6-sialylation of galactose on glycoproteins
-
-
?
additional information
?
-
-
the enzyme catalyzes the formation of the terminal alpha2,6-sialic acid linkages on gangliosides
-
-
?
additional information
?
-
-
no activity with 6'-sialyllactosamine
-
-
?
additional information
?
-
no activity with cytidine-5'-yl-5-(3-[4-Chloro-1,2,3-oxadiazol-3-ium-5-olate]benzamido)-3,5-dideoxy-beta-D-glycero-D-galacto-non-2-ulopyranosid-2''-yl phosphate (CMP-Neu5SydCl)
-
-
-
additional information
?
-
-
the enzyme is responsible for the synthesis of 6'-sialylolifosaccharides in milk
-
-
?
additional information
?
-
-
ST6Gal II shows no activity towards oligosaccharides such as Galbeta1,3GalNAc, Galbeta1,3GlcNAc, lactose, and lacto-N-tetraose, which do not have the Galbeta1,4GlcNAc structure at the nonreducing end of their carbohydrate groups. Relatively low activity towards some glycoproteins, which are considered to have the Galbeta1,4GlcNAc structure at the nonreducing end of the carbohydrate groups
-
-
?
additional information
?
-
-
ST6Gal I sialyltransferase knock-out mouse lacks the main enzyme necessary for the attachment of alpha2,6 sialic acid to N-linked glycoproteins on the cell surface. Even in the absence of detectable alpha2,6 sialic acid in the mouse respiratory tract, human influenza viruses can still infect these mice and grow to similar titers in the lung and trachea as compared to wild-type animals. The presence of a major alpha2,6 sialic acid on N-linked glycoproteins is not essential for human influenza virus infection in mice
-
-
?
additional information
?
-
-
low activity with several methylated substrates, no activity with UDP-Gal, UDP-GalNAc and UDP-Glc as donor substrates
-
-
?
additional information
?
-
-
enzyme does not recognize type I oligosaccharides
-
-
?
additional information
?
-
-
DELTA15Pd2,6ST preferentially cleaves alpha2,6-linked sialic acid
-
-
?
additional information
?
-
-
the enzyme exhibits a unique regioselectivity and is able to sialylate internal galactose residues in poly-LacNAc extended glycans
-
-
?
additional information
?
-
-
low activity with several methylated substrates, no activity with UDP-Gal, UDP-GalNAc and UDP-Glc as donor substrates
-
-
?
additional information
?
-
-
enzyme does not recognize type I oligosaccharides
-
-
?
additional information
?
-
-
neuraminidase activity is specific for the Neu5Acalpha2,6Gal linkage
-
-
?
additional information
?
-
-
neuraminidase activity is specific for the Neu5Acalpha2,6Gal linkage
-
-
?
additional information
?
-
no sialidase activity is detected for the alpha2,6-sialyltransferase
-
-
?
additional information
?
-
-
thyroglobin is no substrate
-
-
?
additional information
?
-
-
no activity with submaxillary asialo-mucin
-
-
?
additional information
?
-
-
no activity with submaxillary asialo-mucin
-
-
?
additional information
?
-
-
no activity with submaxillary asialo-mucin
-
-
?
additional information
?
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-
very low activity with prothrombin and native alpha1-acid glycoprotein, no activity with transferrin, asialo-agalacto-alpha1-acid glycoprotein
-
-
?
additional information
?
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-
no activity with antifreeze glycoprotein
-
-
?
additional information
?
-
-
no activity with antifreeze glycoprotein
-
-
?
additional information
?
-
-
no activity with the CMP-NeuAc analogues disodium[(5-acetamido-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosyl)onate] (methyl-beta-D-ribofuranosid-5-yl) phosphate and bis(triethylammonium) [(5-acetamido-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosyl)onate] [(resorcin-4-yl) (1-deoxy-beta-D-ribofuranosid-5-yl)] phosphate
-
-
?
additional information
?
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-
addition of alpha2,6-linked sialic acid to the Gal1,4GlcNAc sequence, the preferred ligand for galectin-1, inhibits recognition of this saccharide ligand by galectin-1. The enzyme sialylates N-glycans on CD45, a receptor tyrosine phosphatase that is a T cell receptor for galectin-1. ST6Gal I expression abrogates the reduction in CD45 tyrosine phosphatase activity that results from galectin1 binding. Sialylation of CD45 by the ST6Gal I also prevents galectin-1-induced clustering of CD45 on the T cell surface, an initial step in galectin-1 cell death. Regulation of glycoprotein sialylation may control susceptibility to cell death at specific points during T cell development and peripheral activation
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-
?
additional information
?
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the enzyme functions in Golgi vesicles to terminally sialylate the N-linked oligosaccharides of glycoproteins
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-
?
additional information
?
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human-like sialylated recombinant thyrotropin with sialic acid bound to galactose by both alpha2-3 and alpha2-6 linkages, similar to the native preparation, obtained in CHO cells modified to produce alpha2,6-sialyltransferase
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-
?
additional information
?
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thyroglobin is no substrate
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-
?
additional information
?
-
-
no activity with submaxillary asialo-mucin
-
-
?
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