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Information on EC 2.5.1.60 - protein geranylgeranyltransferase type II

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IUBMB Comments
This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type I (EC 2.5.1.59), constitutes the protein prenyltransferase family of enzymes. Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion .
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The enzyme appears in viruses and cellular organisms
Synonyms
rabggtase, rab geranylgeranyl transferase, rab geranylgeranyltransferase, ggtase-ii, rab ggtase, rabggt, rab gg transferase, geranylgeranyltransferase type ii, rab-ggt, rabggtb, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
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