Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | promotes the phosphorylation of the alpha subunit of enzyme without an effect on beta subunit, and activation of enzyme, insulin increases the amount of geranylgeranylated Rab3 and Rab4 proteins | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | perillyl alcohol inhibits insulin induced activation of enzyme, but not GGTI-298 and alpha-hxdroxyfarnesylphosphonic acid, PD 98056 inhibits the ability of insulin to increase the amount of geranylgeranylated Rab3 and Rab4 proteins | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + protein-cysteine | Mus musculus | enzyme crucial for membrane association and function of Rab proteins in intracellular vesicular trafficking | S-geranylgeranyl-protein + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Mus musculus | - |
fibroblast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + protein-cysteine | substrate are Rab3 and Rab4 | Mus musculus | S-geranylgeranyl-protein + diphosphate | - |
? | |
geranylgeranyl diphosphate + protein-cysteine | enzyme crucial for membrane association and function of Rab proteins in intracellular vesicular trafficking | Mus musculus | S-geranylgeranyl-protein + diphosphate | - |
? |