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Literature summary for 2.5.1.60 extracted from

  • Goalstone, M.L.; Leitner, J.W.; Golovchenko, I.; Stjernholm, M.R.; Cormont, M.; Le Marchand-Brustel, Y.; Draznin, B.
    Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4 (1999), J. Biol. Chem., 274, 2880-2884.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Insulin promotes the phosphorylation of the alpha subunit of enzyme without an effect on beta subunit, and activation of enzyme, insulin increases the amount of geranylgeranylated Rab3 and Rab4 proteins Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information perillyl alcohol inhibits insulin induced activation of enzyme, but not GGTI-298 and alpha-hxdroxyfarnesylphosphonic acid, PD 98056 inhibits the ability of insulin to increase the amount of geranylgeranylated Rab3 and Rab4 proteins Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine Mus musculus enzyme crucial for membrane association and function of Rab proteins in intracellular vesicular trafficking S-geranylgeranyl-protein + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
Mus musculus
-
fibroblast
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine substrate are Rab3 and Rab4 Mus musculus S-geranylgeranyl-protein + diphosphate
-
?
geranylgeranyl diphosphate + protein-cysteine enzyme crucial for membrane association and function of Rab proteins in intracellular vesicular trafficking Mus musculus S-geranylgeranyl-protein + diphosphate
-
?