EC Number   |
Activating Compound |
Reference |
|---|
   2.5.1.60 | Insulin |
promotes the phosphorylation of the alpha subunit of enzyme without an effect on beta subunit, and activation of enzyme, insulin increases the amount of geranylgeranylated Rab3 and Rab4 proteins |
638598 |
| 2.5.1.60 | more |
the enzyme is absolutely dependent on the Rab escort protein, REP, cloning and expression of His-tagged REP in Escherichia coli, and purification, overview, recombinant Arabidopsis thaliana REP-6His stimulates Rab geranylgeranylation activity in plant but not yeast cell extracts, overview |
675344 |
| 2.5.1.60 | Nonidet P-40 |
- |
638599 |
| 2.5.1.60 | Nonidet P-40 |
in assay requirement |
638600 |
| 2.5.1.60 | Nonidet P-40 |
the plant enzyme activity is enhanced by detergent |
638599 |
| 2.5.1.60 | Rab escort protein |
REP, unlike the other prenyltransferases, farnesyl-transferase and geranylgeranyl-transferase I (GGTaseI), RabGGTase does not rely on a consensus sequence such as the CAAX box, but instead has delegated substrate recognition to a third protein, the Rab escort protein |
739491 |
| 2.5.1.60 | Rab escort protein |
RGGT increases the ability of Rab escort protein to extract endogenous prenylated Rabs from membranes in vitro by stabilizing a soluble Rab escort protein-RGGT-geranylgeranylated Rab complex |
685017 |
