Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.60 extracted from

  • Haney, S.L.; Varney, M.L.; Chhonker, Y.S.; Shin, S.; Mehla, K.; Crawford, A.J.; Smith, H.J.; Smith, L.M.; Murry, D.J.; Hollingsworth, M.A.; Holstein, S.A.
    Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma (2019), Oncogene, 38, 5308-5320 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.60

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Mus musculus
-
pancreatic cancer cell
-
 Mus musculus
-

General Information

General Information Comment Organism
physiological function inhibition of GGTase II, but not GGTase I, leads to an increase in UPR and apoptosis markers. Inhibition produces a retention of mucin MUC1 protein inside the cell. Rab inhibition, via either GGDPS or GGTase II inhibition, results in cytotoxic effects across all tested cell lines Mus musculus