Literature summary for 3.4.24.7 extracted from

Blackburn, J.S.; Rhodes, C.H.; Coon, C.I.; Brinckerhoff, C.E.
RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis (2007), Cancer Res., 67, 10849-10858.

Search for more literature for 3.4.24.7

Application

Application	Comment	Organism
pharmacology	MMP-1 is a potential target in therapy of melanoma	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	MMP-1 enzyme inhibition and downregulation by short hairpin RNA, shRNA, reducing collagenase activity and angiogenesis of melanoma cells, but has no effect on primary tumor growth, xenograft modeling	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	MMP-1 is a single effector of the Raf/MEK/ERK signaling cascade, that prevents progression of melanoma from a primary to metastatic tumor	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell	of invasive melanomas	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	MMP-1 is a single effector of the Raf/MEK/ERK signaling cascade, that prevents progression of melanoma from a primary to metastatic tumor	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
matrix metalloproteinase-1	-	Homo sapiens
MMP-1	-	Homo sapiens
tumor collagenase	-	Homo sapiens

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Release 2023.1 (January 2023)