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Information on EC 3.2.1.49 - alpha-N-acetylgalactosaminidase

for references in articles please use BRENDA:EC3.2.1.49

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IUBMB Comments

The human lysosomal enzyme is involved in the degradation of blood type A epitope.

The enzyme appears in viruses and cellular organisms

Synonyms
alpha-n-acetylgalactosaminidase, alpha-galnac, nagalase, envelope glycoprotein gp160, alpha-naga, alpha-galactosidase b, alpha-nagalase, alpha-galnacase i, alpha-nagal, alpha-galnacase ii, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alpha-D-GalNAc-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H2O = D-GalNAc + beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide
show the reaction diagram
Highest Expressing Human Cell Lines
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